Laura Pisani

Tumor size limits macrophage activation and imaging response to CD47 blockade in osteosarcoma

Raheleh Roudi, Giovanni Marco Saladino, Iryna Vasyliv, Laura Pisani et autres

Despite robust preclinical activity, CD47-targeting agents demonstrate limited single-agent efficacy in osteosarcomas. The purpose of our study was to investigate whether tumor size at baseline affects tumor-associated macrophage (TAM) response to CD47 mAb, as measured by ferumoxytol-MRI. Thirty female NOD SCID gamma …

us (code pays fourni par la source)

Correction: Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapy

Zahra Shokri Varniab, Edwin Chang, Jie Wang, Ramesh Duwa et autres

The original version of this Article contained an error where an incorrect version of Fig. 9 was published. Specifically, Panels B and F inadvertently display H&E images from a different experimental group than indicated and the magnification across panels is inconsistent.

us, gb (code pays fourni par la source)

MRI detection of senescent cells in porcine knee joints with a β-galactosidase responsive Gd-chelate

Kerem Nernekli, Dilyana B. Mangarova, Vidyani Suryadevara, Mohammadjavad Hajipour et autres

Senescent cells promote osteoarthritis progression through the secretion of inflammatory mediators. Preclinical studies have identified senescence-associated beta-galactosidase (β-gal) as a biomarker of senescence, but in vivo detection remains challenging. Here, we evaluated whether a β-gal responsive gadolinium (Gd) chelate can non-invasively detect …

us (code pays fourni par la source)

Abstract 5797: Impact of baseline tumor size on response to anti-CD47 immunotherapy in an osteosarcoma mouse model

Raheleh Roudi, Iryna Vasylkiv, Laura Pisani, Tie Liang et autres

Abstract Background and Purpose. Activation of tumor-associated macrophages (TAMs) by CD47 mAb therapy can be monitored with ferumoxytol-enhanced magnetic resonance imaging (MRI). The purpose of our study was to investigate if tumor size at baseline affects TAM response to CD47 mAb, as …

us (code pays fourni par la source)

Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapy

Zahra Shokri Varniab, Edwin Chang, Jie Wang, Ramesh Duwa et autres

Matrix metalloproteinase-14 (MMP-14) and Cathepsin-B (Cat-B) are overexpressed in glioblastoma (GBM) and not normal brain, making them promising targets for prodrug activation. We investigated a novel combination therapy using two tumor-enzyme activatable theranostic nanoprobes (TNP): TNP-MMP-14, which disrupts the blood tumor barrier …

us, gb (code pays fourni par la source)

Campsiite® phase I/II/III: an interim clinical study update of RGX-121, an investigational gene therapy for the treatment of neuronopathic mucopolysaccharidosis type II (MPS II)

Paul Harmatz, Can Fıçıcıoğlu, Roberto Giugliani, Deepa Rajan et autres

Multimodal imaging approach to track theranostic nanoparticle accumulation in glioblastoma with magnetic resonance imaging and intravital microscopy

Giovanni Marco Saladino, Dilyana B. Mangarova, Kerem Nernekli, Jie Wang et autres

observations. The presented multimodal imaging approach enabled a quantitative correlation between MRI contrast enhancement at the macroscopic level and NP accumulation in the tumor microenvironment. These studies lay the groundwork for the precise evaluation of the tumor targeting of theranostic NPs.

us, gb (code pays fourni par la source)

Combining Clinical and Gene Expression Variables via Knowledge Graph Embedding for Prediction of Coronary Artery Stenosis

Giuseppe Albi, Arianna Dagliati, Chiara Vavassori, Laura Pisani et autres

it (code pays fourni par la source)

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

Tsutomu Shinohara, Jan-Renier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow et autres

BACKGROUND: ) is generated in pulmonary arteries (PAs; 100-500 µm) in congenital heart defects causing PA hypertension (PAH) and in idiopathic PAH with occlusive vascular remodeling. Endothelial-to-mesenchymal transition (EndMT) is a feature of PAH. We hypothesize that HSS induces EndMT, contributing to …

us, jp, kr, Afrique du Sud, ca, at, de (code pays fourni par la source)

A Novel Mouse Model for Cerebral Inflammatory Demyelination in X‐Linked Adrenoleukodystrophy: Insights into Pathogenesis and Potential Therapeutic Targets

Ezzat Hashemi, Isha N. Srivastava, Alejandro Aguirre, Ezra Yoseph et autres

OBJECTIVE: X-linked adrenoleukodystrophy (ALD) is caused by mutations in ABCD1, a peroxisomal gene. More than half of males with an ABCD1 mutation develop inflammatory cerebral demyelination (cALD), but underlying mechanisms remain unknown and therapies are limited. We sought to develop and characterize …

us, ca (code pays fourni par la source)

Reproducibility and repeatability of quantitative T2 and T2* mapping of osteosarcomas in a mouse model

Raheleh Roudi, Laura Pisani, Fabrizio Pisani, Tie Liang et autres

BACKGROUND: New immunotherapies activate tumor-associated macrophages (TAMs) in the osteosarcoma microenvironment. Iron oxide nanoparticles (IONPs) are phagocytosed by TAMs and, therefore, enable TAM detection on T2*- and T2-weighted magnetic resonance images. We assessed the repeatability and reproducibility of T2*- and T2-mapping of …

us (code pays fourni par la source)

CAMPSIITE™ Phase I/II/III: An interim clinical study update of RGX-121, an investigational gene therapy for the treatment of neuronopathic mucopolysaccharidosis type II (MPS II)

Laura Pisani, Can Fıçıcıoğlu, Paul Harmatz, Roberto Giugliani et autres

us, br (code pays fourni par la source)