Emir Çapkınoğlu

Transcriptional Reprogramming of Cancer Metabolism: Tricholoma terreum Inhibits Nucleotide Biosynthesis and Energy Flux in MCF-7 Cells by Downregulating DHFR, TK1, and ENO1

Levent Gülüm, Emrah Güler, Emir Çapkınoğlu, Ayşe Büşranur Çelik et autres

Tricholoma terreum, a mushroom rich in bioactive compounds, exhibits notable antioxidant and anticancer properties. Despite its traditional use, its effects on breast cancer metabolism remain underexplored. Here, we conducted comprehensive phytochemical and volatile organic compound profiling of T. terreum extracts and evaluated …

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The Effect of Cannabidiol on Cancer-Pathway Genes in Doxorubicin-Sensitive and Resistant Breast Cancer Cells

Kezban Uçar Çifci, Ayşe Büşranur Çelik, Ebru Güçlü, Nisanur Şahinoğlu et autres

Purpose: Cannabidiol (CBD) is a primary bioactive, non-intoxicating cannabinoid found in the cannabis plant. Studies have shown that CBD causes anticancer activity by inhibiting the expression of growth factors and inducing apoptosis, leading to cell cycle arrest. In this study, we aimed …

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Evolving Concepts and Contemporary Management of Early-Stage Breast Cancer: An Evidence-Based Approach to Grey Zones from a Comprehensive Breast Unit Part 1: Locoregional Therapy, Pathology, Radiology

Elif Şenocak Taşçı, Halil Kara, Emir Çapkınoğlu, Onur Dülgeroğlu et autres

Breast cancer is the most frequently diagnosed malignancy among women worldwide, and significant progress in systemic therapy, surgical techniques, and radiotherapy has contributed to improved clinical outcomes. However, many clinical scenarios encountered in daily practice are not fully addressed by randomized trials, …

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From Phytochemical Characterization to Energy Metabolism-Driven Molecular Responses: The Anticancer Potential of Lactarius deliciosus (L.) Gray in Breast Cancer Cells

Levent Gülüm, Emrah Güler, Emir Çapkınoğlu, Ayşe Büşranur Çelik et autres

Background/Objectives: This study aimed to investigate the phytochemical composition, antioxidant capacity, and anticancer potential of methanol and ethanol extracts of Lactarius deliciosus (L.) Gray in MCF-7 breast cancer cells, focusing on their effects on energy metabolism and related molecular mechanisms. Methods: In …

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Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism

Levent Gülüm, Emrah Güler, Emir Çapkınoğlu, Ayşe Büşranur Çelik et autres

Ganoderma lucidum has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of G. lucidum …

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Safety profile of MESMO® breast implants in breast reconstruction: A retrospective analysis

Buse Capkinoglu, Emir Çapkınoğlu, Bülent Çıtgez, Akın Yücel

ABSTRACT Background Breast implant-associated complications, including rare events like breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), raised concerns regarding implant safety. Micro-textured implants, such as the MESMO® implants, were developed to reduce these risks. However, limited data exist on the safety and …

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Anticancer and Immunomodulatory Effects of a Thiazolyl Benzodiazepine Targeting HSP90 in ER+ Breast Cancer

Kübra Açıkalın Coşkun, Lütfi Tutar, Kezban Uçar Çifci, Mervenur Al et autres

Background: Heat shock protein 90 (HSP90) is a molecular chaperone that stabilizes numerous oncogenic proteins and supports tumor survival. Small molecules targeting HSP90 offer a novel approach to overcome drug resistance and immune suppression in breast cancer. Methods: A novel thiazolyl benzodiazepine …

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Utilization of Serratus Muscle-Fascia Flap to Ensure Implant Stability in Prepectoral Direct-to-Implant Reconstruction

Mehmet Sağır, Erdem Güven, Onur Saylık, Emir Çapkınoğlu et autres

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Comparison of Early Results of Laparoscopic Transabdominal Preperitoneal and Total Extraperitoneal Repair in Recurrent Inguinal Hernia

Cihan Atar, Emir Çapkınoğlu, Burak Yavuz, Ahmet Onur Demirel et autres

Background: The optimal surgical approach for recurrent inguinal hernia remains controversial. Among the commonly used laparoscopic techniques, transabdominal preperitoneal (TAPP) and total extraperitoneal (TEP) repairs are frequently performed, yet data comparing their short-term outcomes in recurrent cases are limited. This study aimed …

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Helicobacter pylori relationship in cases of coexistence of gastritis and gallbladder disease

Ramazan Uçak, Özlem Ton, Omer Faruk Dilbaz, Cemal Kaya et autres

Purpose: We aimed to investigate the effect of Helicobacter Pylorii (HP) on the development of gallbladder diseases and cholelithiasis and its relationship with gastritis. Methods: 282 gastritis cases with follow-up and operated gallbladder material were included in the study. All histomorphological findings, …

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A bibliometric study of articles on laparoscopic sleeve gastrectomy published in Science Citation Index Expanded Journals: Analysis of 4269 articles published between 1998-2020

Emir Çapkınoğlu, Banu Yiğit, Bülent Çıtgez

Purpose: In the last decade, the popularity of laparoscopic sleeve gastrectomy (LSG) among surgeons has increased, and the desire to get information has been accelerated. Holistic evaluation of scientific publications, including publication and citation metrics, is the definition of "Bibliometrics". In the …

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Positive lymph node ratio as a prognostic factor for gastric cancer patients: Is it going to supersede positive lymph node number in guidelines?

Emir Çapkınoğlu, Aydın Eray Tufan, Sinan Ömeroğlu, Mert Tanal et autres

Gastric malignancies constitute the sixth most common cancer with regards to incidence and have the fifth most mortality rates. Extended lymph-node dissection is the surgical modality of choice while treating advanced stage gastric cancer. It is yet a topic of debate, whether …

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