Accès ouvert
2016
article
OpenAlex
Karmel V. Headen, Afolabi O. Ogunleye, David E. Williams
ABSTRACT Aims Our laboratory has found that lysophosphatidic acid (LPA) and its cognate receptors [LPARs, (LPA1–6)] expressed by human gingival fibroblasts (GF) and periodontal ligament fibroblasts (PDLF) play key roles in oral fibroblast homeostasis and are implicated in the inflammation seen in …
us
(code pays fourni par la source)
2015
article
OpenAlex
D. Roselyn Cerutis, Michael D. Weston, Yazen Alnouti, Sai Praneeth Bathena et autres
BACKGROUND: The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. METHODS: Microarray analysis was used to test the …
us
(code pays fourni par la source)
2013
article
OpenAlex
D. Roselyn Cerutis, Michael D. Weston, Martha E. Nunn, Afolabi O. Ogunleye et autres
Our laboratory has established that lysophosphatidic acid (LPA) regulates the biology of human oral fibroblasts, and that gingival fibroblasts (GF) express the LPA 1–5 receptor subtypes. We have also shown that LPA controls immediate‐early gene transcription of inflammatory cytokines, and their receptors …
us
(code pays fourni par la source)
2010
article
OpenAlex
D. Roselyn Cerutis, Karmel V. Headen, Gregory J. P. Perry, Lawrence C. Parrish et autres
LPA is a pleiotropic G protein‐coupled lipid mediator involved in many homeostatic and patho‐physiologic aspects of cellular regulation. It binds to LPA1‐6 receptor (LPAR ) subtypes. It is co‐released by activated platelets together with platelet‐derived growth factor (PDGF). We have published that …
fr, us
(code pays fourni par la source)
Accès ouvert
2009
article
OpenAlex
Joju George, Karmel V. Headen, Afolabi O. Ogunleye, Greg A. Perry et autres
BACKGROUND: We showed that the pluripotent platelet growth factor and mediator lysophosphatidic acid (LPA) controls key regenerative responses of human gingival fibroblasts (GFs) and periodontal ligament fibroblasts (PDLFs) and positively modulates their responses to platelet-derived growth factor (PDGF). This study determined which …
us
(code pays fourni par la source)
2009
article
OpenAlex
D. Roselyn Cerutis, Karmel V. Headen, Timothy P. McVaney, Afolabi O. Ogunleye et autres
LPA, a G protein‐coupled lipid mediator involved in wound healing, binds to LPA 1‐5 receptors (LPARs). It is co‐released by activated platelets together with platelet‐derived growth factor (PDGF). We have published that human gingival (GF) and periodontal ligament (PDLF) fibroblasts express LPA …
ru, us
(code pays fourni par la source)
2008
article
OpenAlex
D. Roselyn Cerutis, Joju George, Karmel V. Headen, Stephanie A. Brady et autres
Background: LPA 1–5 receptors (LPARs) bind lysophosphatidic acid (LPA), a G protein‐coupled lipid mediator involved in wound healing. We have published that LPA regulates the growth and migration of human gingival (GF) and periodontal ligament (PDLF) fibroblasts, and that they express LPA …
us, ru
(code pays fourni par la source)