Annick Méjean

Biosynthetic studies on a promising anticancer drug, cryptophycin-1 produced by the cyanobacterium Nostoc sp. ATCC 53789

Annick Méjean, Catherine Dupré, Mariem Ben Hammouda, Jack Legrand et autres

International audience

Improving a green process for Cryptophycin production from cyanobacteria biomass

Catherine Dupré, Mariem Ben Hammouda, Jack Legrand, Dominique Grizeau et autres

International audience

Isolation, purification and chemical diversity of cryptophycin analogues

Thomas Gaslonde, Vincent Jactel, Olivier Ploux, Annick Méjean et autres

International audience

An ecofriendly process to produce secondary metabolites from Nostoc species; application to the biosynthesis of Cryptophycine within photobioreactors

Catherine Dupré, Mariem Ben Hammouda, Jack Legrand, Dominique Grizeau et autres

International audience

fr (code pays fourni par la source)

Identification of Cyanobacteria and Its Potential Toxins in the Joanes I Reservoir, Bahia, Brazil

Maria Teresa Araujo Pinheiro Menescal, Edna dos Santos Almeida, Emerson Andrade Sales, Annick Méjean et autres

The Joanes I Reservoir is responsible for 40% of the drinking water supply of the Metropolitan Region of Salvador, Bahia, Brazil. For water sources such as this, there is concern regarding the proliferation of potentially toxin-producing cyanobacteria, which can cause environmental and …

br, fr (code pays fourni par la source)

Identification of 7-Deoxy-desulfo-argino-cylindrospermopsin, the Missing Piece in Cylindrospermopsin Biosynthesis

Annick Méjean, Olivier Lequin, Olivier Ploux

Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry experiments. We have purified …

fr (code pays fourni par la source)

Biosynthesis of Cylindrospermopsin in Cyanobacteria: Characterization of CyrJ the Sulfotransferase

Annick Méjean, Olivier Ploux

7-Deoxy-desulfo-cylindrospermopsin was purified at small-scale from the supernatant of a culture of the cyanobacterium Oscillatoria sp. PCC 10702. This metabolite was obtained in a pure form using a three-step chromatographic procedure, and its identity was confirmed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). …

fr (code pays fourni par la source)

Biosynthesis of Anatoxins in Cyanobacteria: Identification of the Carboxy-anatoxins as the Penultimate Biosynthetic Intermediates

Andreja Kust, Annick Méjean, Olivier Ploux

Anatoxin-a, homoanatoxin-a, and dihydroanatoxin-a are potent cyanobacterial neurotoxins. They are biosynthesized in cyanobacteria from proline and acetate by a pathway involving three polyketide synthases. We report the identification of carboxy-anatoxin-a, carboxy-homoanatoxin-a, and carboxy-dihydroanatoxin-a in acidic extracts of Cuspidothrix issatschenkoi CHARLIE-1, Oscillatoria sp. …

fr, cz (code pays fourni par la source)

Active Fluids: Effects of Hydrodynamic Stress on Growth of Self-Propelled Fluid Particles

Hadi Fadlallah, Mojtaba Jarrahi, Laboratoire d'informatique pour la mécanique et les sciences de l'ingénieur – LIMSI – CNRS – UPR 3251, Univ. Paris-Sud, Université Paris-Saclay, 91400 Orsay, France, Éric Herbert et autres

Under the current global energy crisis the interests in developing a third generation of biofuels produced from non-food feedstock such as microalgae and cyanobacteria have clearly increased. Hydrodynamic stress, always present in cultivation process of these microorganisms, is an essential factor to …

fr (code pays fourni par la source)

Cyanotoxins: Toxins from prokaryotic blue-green algae with immense impact

Rabia Mazmouz, Tianzhe Liu, Brett Anthony Neilan, Annick Méjean et autres

fr, au (code pays fourni par la source)

Anatoxin-a and analogs: Occurrence, biosynthesis and detection

Annick Méjean, Rabia Mazmouz, Insaf Essadik, Olivier Ploux

fr (code pays fourni par la source)

Characterization of CyrI, the hydroxylase involved in the last step of cylindrospermopsin biosynthesis: Binding studies, site-directed mutagenesis and stereoselectivity

Rabia Mazmouz, Insaf Essadik, Djemel Hamdane, Annick Méjean et autres

fr (code pays fourni par la source)