Anthony O. Gramolini

Advanced physiological maturation of human iPSC-derived cardiomyocytes using an algorithm-directed optimization of defined media components

Neal I. Callaghan, Lauren J. Durland, WENLIANG CHEN, Uroš Kuzmanov et autres

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold tremendous promise for in vitro modeling to assess native myocardial function and disease mechanisms, as well as testing drug safety and efficacy. However, current hiPSC-CMs are functionally immature, resembling in vivo CMs of fetal …

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Engineering a multilayered micro-vascularized soft tissue graft: Integrating polyurethane composite nanofibres with co-cultures of human adipose-derived endothelial and stem cells

Brian C. W. Webb, Genevie Tran, Kirtana Devaraj, Emma Lindsay et autres

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Subcellular Proteomic Analyses Reveal REEP5 Knockdown in the Mouse Heart Disrupts Mitochondrial Networks

M. Di Paola, Cristine J. Reitz, Uroš Kuzmanov, Kateleen Jia et autres

Receptor Expression-Enhancing Protein 5 (REEP5) is a cardiac-enriched, membrane-shaping protein localized to the sarco(endo)plasmic reticulum (SR/ER), where it supports membrane network architecture and cardiomyocyte function. While REEP5 has been implicated in calcium handling and contractility, its role in regulating inter-organelle communication and …

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Smooth muscle cell-like support cells accelerate the autologous endothelialization of a polyurethane scaffold for vascular engineering

Kate D. MacQuarrie, Katya A. D’Costa, Jeremy A. Antonyshyn, Seema Saini et autres

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Abstract 4357888: Evaluating the Temporal and Sociodemographic Generalizability of the Emergency Heart Failure Mortality Risk Grade

Karem Abdul-Samad, Xuesong Wang, Peter Austin, Chris McIntosh et autres

Background: The Emergency Heart Failure Mortality Risk Grade (EHMRG) models are a series of clinically validated models to predict (7-day and 30-day) mortality in acute heart failure (AHF) patients. Although EHMRG models were validated in 2015, it is unknown whether EHMRG maintained …

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Title: Hacs1 is a myeloma immunosuppressor driving pro-tumorigenic myelopoiesis and myeloid cell differentiation through MS4A3/IL3/GM-CSF signaling

Dingyan Wang, Xiao‐Yan Wen, Jamie Li, Rui Qu et autres

Abstract Introduction: The bone marrow (BM) microenvironment supports survival of the malignant multiple myeloma (MM) cells and is composed of cellular components that foster MM development and progression by suppression of immune responses. Despite major progresses in understanding the MM biology and …

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Systems biology approaches investigating mitochondrial dysfunction in cyanotic heart disease: a systematic review

Malak Elbatarny, Mostin Hu, John C. Coles, Seema Mital et autres

BACKGROUND: Cyanotic congenital heart disease (CCHD) affects over 3 million individuals globally and can progress to heart failure. Mitochondrial dysfunction is well established in adult heart failure and is also a central feature of CCHD. CCHD cyanosis itself contributes to further mitochondrial …

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Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells

Suja Shrestha, Beining Yang, Allen C. T. Teng, Ryan M. Marks et autres

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Characterizing the mechanisms and implications of αT-catenin phospho-regulation at the cardiomyocyte intercalated disc

Daniel Davoudpour, Cristine J. Reitz, Uroš Kuzmanov, Omar Hamed et autres

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Sarco(endo)plasmic reticulum membrane protein REEP5 regulates mitochondrial dynamics in the mouse heart

Michelle Di Paola, Cristine J. Reitz, Uroš Kuzmanov, Kateleen Jia et autres

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Investigating the role of key sarco(endo)plasmic reticulum shaping proteins on cardiomyocyte structure and development

Kateleen Jia, Michelle Di Paola, Cristine J. Reitz, Allen C. T. Teng et autres

ca (code pays fourni par la source)

Aggresome Formation in PLNR14Δ Cardiomyopathy: the Role of Fkbp8

Ava Vandenbelt, Allen C. T. Teng, Wenping Li, Anthony O. Gramolini

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