Saumini Srinivasan

Longitudinal Changes in Pulmonary Function After Treatment of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study

Neel S Bhatt, Lu Xie, Kendrick Li, DeoKumar Srivastava et autres

RATIONALE/ OBJECTIVES: Data on longitudinal changes in pulmonary function in long-term childhood cancer survivors remain limited. Using a well-characterized cohort of childhood cancer survivors, we analyzed these changes through serial PFT assessments among those exposed to pulmonary-toxic therapy, with available radiation dosimetry …

Afrique du Sud, us (code pays fourni par la source)

Impact of Non-Compliance with NIH Consensus Guidelines for PFT Performance in Allogeneic Hematopoietic Cell Transplant Recipients.

Gregory A. Yanik, Gavin C. Raab, Amrita Pawar, Danielle Stahlbaum et autres

us (code pays fourni par la source)

P-543. Role of respiratory viral infections in Airflow Obstruction after Pediatric Hematopoietic Cell Transplantation

Sapna A Pardasani, Ali Suliman, Jose Ferrolino, Ronald H Dallas et autres

Abstract Background Respiratory Viral Infections (RVIs) in allogeneic hematopoietic cell transplant (allo-HCT) recipients can cause airflow obstruction (AFO), leading to pneumonia or death, particularly in those with preexisting conditions. Despite this risk, the impact of community-acquired RVI on PFTs in pediatric patients …

us, jp (code pays fourni par la source)

Pulmonary function testing in pediatric allogeneic stem cell transplant recipients to monitor for Bronchiolitis obliterans syndrome: a systematic review

William A. Gower, Maximiliano Tamae Kakazu, Shivanthan Shanthikumar, Saumini Srinivasan et autres

BACKGROUND: Bronchiolitis obliterans syndrome (BOS) represents a significant source of morbidity and non-relapse mortality among children and young adults treated with allogeneic hematopoietic stem cell transplantation (aHSCT). Pulmonary function testing (PFT) pre- and post-aHSCT may allow for pre-symptomatic detection of BOS, and …

us, au, fr (code pays fourni par la source)

Utility and Safety of Bronchoalveolar Lavage for Diagnosis and Management of Respiratory Illnesses in Immunocompromised Children

A Abraham, Amanda Green, Jose Ferrolino, Tim Flerlage et autres

BACKGROUND: Acute respiratory illnesses (ARIs) in immunocompromised children have diverse causes, which can obscure accurate diagnosis and lead to unnecessary antimicrobial use. The risk-benefit ratio of bronchoalveolar lavage (BAL) in these patients is debated. This study aimed to evaluate the safety, yield, …

us (code pays fourni par la source)

Detection of Bronchiolitis Obliterans Syndrome after Pediatric Hematopoietic Stem Cell Transplantation: An Official American Thoracic Society Clinical Practice Guideline

Shivanthan Shanthikumar, William A. Gower, Saumini Srinivasan, Jonathan H. Rayment et autres

Abstract Background Many children undergo allogeneic hematopoietic stem cell transplantation (HSCT) for the treatment of malignant and nonmalignant conditions. Unfortunately, pulmonary complications occur frequently post-HSCT, with bronchiolitis obliterans syndrome (BOS) being the most common noninfectious pulmonary complication. Current international guidelines contain conflicting …

au, us, ca, fr, ch (code pays fourni par la source)

Pulmonary Function Monitoring for Bronchiolitis Obliterans Syndrome in Pediatric Allogeneic Stem Cell Transplant Recipients

William A. Gower, Maximiliano Tamae Kakazu, Shivanathan Shanthikumar, Saumini Srinivasan et autres

Subgroup analysisPre-defined subgroups: Young children (<5 years age) who are unable to perform PFT, Children receiving whole body radiation prior to transplant. Sensitivity analysisPre-defined analysis: If enough studies exist with pre-transplant radiation then a sensitivity analysis will be done for studies without …

Intrapulmonary administration of recombinant activated factor VII in pediatric, adolescent, and young adult oncology and hematopoietic cell transplant patients with pulmonary hemorrhage

Caitlin Hurley, Jennifer McArthur, Jeffrey M. Gossett, Elizabeth A. Hall et autres

Introduction: Diffuse alveolar hemorrhage (DAH) is a devastating disease process with 50-100% mortality in oncology and hematopoietic cell transplant (HCT) recipients. High concentrations of tissue factors have been demonstrated in the alveolar wall in acute respiratory distress syndrome and DAH, along with …

us (code pays fourni par la source)

Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Maria Otth, Rahel Kasteler, Renée L. Mulder, Jennifer E. Agrusa et autres

Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Childhood Cancer Guideline Harmonization Group established and convened a panel of 33 experts to develop evidence-based …

ch, nl, us, il, gb, de, fr (code pays fourni par la source)

PULMONARY SURVEILLANCE IN PEDIATRIC HEMATOPOIETIC STEM CELL TRANSPLANT-- A MULTINATIONAL MULTIDISCIPLINARY SURVEY

Shivanthan Shanthikumar, William A. Gower, M.F. Abts, Deborah R. Liptzin et autres

Background Hematopoietic Stem Cell Transplant (HSCT) is an established treatment for malignant and non-malignant conditions and pulmonary disease is a leading cause of late term morbidity and mortality. Accurate and early detection of pulmonary complications is a critical step in improving long …

au, us (code pays fourni par la source)

Recommendations for surveillance of pulmonary dysfunction among childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Maria Otth, Rahel Kasteler, Renée L. Mulder, Jennifer E. Agrusa et autres

ABSTRACT Childhood, adolescent, and young adult (CAYA) cancer survivors are at risk of pulmonary dysfunction. Current follow-up care guidelines are discordant. Therefore, the International Late Effects of Childhood Cancer Guideline Harmonization Group established and convened a panel of 33 experts to develop …

ch, nl, us, il, gb, de, fr (code pays fourni par la source)

Data from Approach for Classification and Severity Grading of Long-term and Late-Onset Health Events among Childhood Cancer Survivors in the St. Jude Lifetime Cohort

Melissa M. Hudson, Matthew J. Ehrhardt, Nickhill Bhakta, Malek Baassiri et autres

Abstract Characterization of toxicity associated with cancer and its treatment is essential to quantify risk, inform optimization of therapeutic approaches for newly diagnosed patients, and guide health surveillance recommendations for long-term survivors. The NCI Common Terminology Criteria for Adverse Events (CTCAE) provides …