Thangiah Geetha

Pre-post changes in physiological, cognitive, and motivational outcomes following an active video game intervention in adolescents and adults: a pilot study

Ashley Williams, Danielle D. Wadsworth, Thangiah Geetha

Background Active video games (AVG) are emerging as a promising home-based strategy to increase physical activity by integrating movement into interactive gameplay. However, evidence remains limited regarding their effectiveness across physiological, cognitive, and motivational outcomes in adolescents and adults within household settings. …

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Urinary volatile organic compounds as potential non-invasive markers for childhood obesity

Adebowale Samuel Oyerinde, Jeremy Carson, M.L. Gibson, Jackquoia Baulding et autres

BACKGROUND: Childhood obesity is a complex disease and adversely affects multiple organ systems and increases the risk for several health problems, including diabetes, cancer, atherosclerosis, and premature cardiovascular disease in adulthood. This study aimed to identify differences in volatile organic compounds (VOCs) …

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Non-invasive epigenetic protein signatures associated with childhood obesity

Erika M. Richter, Priyadarshni Patel, Jeganathan R. Babu, Thangiah Geetha

BACKGROUND: Childhood obesity is a major predictor of lifelong chronic disease, yet the biological mechanisms linking early-life exposures to adiposity remain incompletely understood. Inflammatory and metabolic proteins have been implicated in obesity-related pathways, but their clinical utility in children is limited by …

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Deep learning-based joint analysis of diabetic retinopathy and glaucoma in retinal fundus images

Thangiah Geetha, C.R. Hema

In current times, Diabetic retinopathy (DR) might be more difficult to diagnose when coexisting with glaucoma, since the two diseases share retinal abnormalities. Worldwide, DR is one of the most common causes of blindness. Conventional convolutional neural network (CNN)-based approaches struggle significantly …

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Epigenetic Impact of Sleep Timing in Children: Novel DNA Methylation Signatures via SWAG Analysis

Erika Richter, Priyadarshni Patel, Yagmur Yavuz Ozdemir, Ukamaka V. Nnyaba et autres

Pediatric obesity is rising globally, and emerging evidence suggests that sleep timing may influence metabolic health through epigenetic mechanisms. This study investigated epigenome-wide DNA methylation patterns associated with bedtime in children and explored their biological relevance. Children aged 6–10 years were classified …

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Exercise, Epigenetics, and Body Composition: Molecular Connections

Ashley Williams, Danielle D. Wadsworth, Thangiah Geetha

Exercise plays a crucial role in promoting overall health by activating molecular pathways that contribute to the prevention and management of chronic diseases, slowing epigenetic aging, improving body composition, and reducing the risk of obesity. In skeletal muscle, these benefits are largely …

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Short‐term risks and benefits of hydroxyurea (hydroxycarbamide)‐induced transfusion independence in patients with beta‐thalassaemia syndromes

B. R. Sevanthini, Santhosh Hegde, Tejashree Sridhar, Deepa Trivedi et autres

Clinical outcomes of hydroxyurea (hydroxycarbamide)-induced transfusion independence in patients with β-thalassaemia syndromes.

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Urinary Volatile Organic Compounds in Obese vs. Normal Weight Children: Insights Into Racial and Socioeconomic Disparities

Adebowale Samuel Oyerinde, Jeganathan Ramesh Babu, Jackquoia Baulding, Melissa Boersma et autres

adiponectin/leptin ratio provides a better understanding of obesity, as excess adiposity may decrease this ratio and impair adipose tissue function.

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Effect of H2O2 induced oxidative stress on volatile organic compounds in differentiated 3T3-L1 cells

Adebowale Samuel Oyerinde, Vaithinathan Selvaraju, Melissa Boersma, Jeganathan Ramesh Babu et autres

Oxidative stress (OS) refers to the disruption in the balance between free radical generation and antioxidant defenses, leading to potential tissue damage. Reactive oxygen species (ROS) can interact with biological components, triggering processes like protein oxidation, lipid peroxidation, or DNA damage, resulting …

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Lupeol Attenuates Palmitate-Induced Hypertrophy in 3T3-L1 Adipocytes

Vaithinathan Selvaraju, S. Ramesh Babu, Robert L. Judd, Thangiah Geetha

Obesity is characterized by the enlargement of adipose tissue due to an increased calorie intake exceeding the body's energy expenditure. Changes in the size of adipose tissue can lead to harmful consequences, with excessive fat accumulation resulting in adipocyte hypertrophy and promoting …

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Evaluating the Safety, Efficacy, and Outcomes of a Targeted Invasive Prenatal Screening Program for Hemoglobinopathies in Rural and Semi-Urban India

T. Venkata Sridhar, Sheriff Anusha, Sundar Periyavan, Balasubramani Rengaraj et autres

Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds

Lauren Jun, Ya‐Xiong Tao, Thangiah Geetha, Jeganathan Ramesh Babu

PURPOSE OF REVIEW: The global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects on various tissues within the human body. Among these tissues, skeletal muscle has gained attention due to its susceptibility to obesity-related …

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