Beatrice Mahler

Pulmonary Metastases from a Hemangiopericytoma/Solitary Fibrous Tumor Spectrum Neoplasm in a Patient with a Poorly Documented Thigh Tumor: A Case Report

Justina Antonela Dragomir, Alexandru Stoichiță, Silviu Gabriel Vlăsceanu, Matache Radu Șerban et autres

Background and Clinical Significance: Solitary fibrous tumor (SFT), historically termed hemangiopericytoma (HPC), is a rare fibroblastic mesenchymal neoplasm with variable biological behavior. Pulmonary involvement is uncommon and may represent either a primary thoracic tumor or metastatic disease from an extrapulmonary site. Its …

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Antimicrobial Resistance Profile of Klebsiella pneumoniae Clinical Isolates at a Tertiary Pulmonology-Critical Care Centre in Romania: A Five-Year Retrospective Study (2021–2026)

Loredana Sabina Cornelia Manolescu, Mădălina Preda, Oana Popescu, Beatrice Mahler et autres

Background: Klebsiella pneumoniae is a leading cause of healthcare-associated infections and a major vehicle for the dissemination of antimicrobial resistance (AMR). Romania ranks among the most affected European countries for carbapenem-resistant K. pneumoniae (CRKP), yet data from specialized pulmonology–critical care settings remain …

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AI-generated treatment recommendations versus real-world treatment decisions in newly diagnosed lung cancer: a blinded comparative pilot study (Preprint)

Andrei Popescu, Mara Jidveian-Popescu, Beatrice Mahler, Rodica Olteanu et autres

BACKGROUND AI use in clinical decision making is increasingly frequent. How treatment recommendations generated by large language models (LLMs) compare with real-world treatment decisions remains poorly characterized. OBJECTIVE To assess whether AI-generated treatment recommendations are rated as appropriate as real-world MDT decisions …

Functional Stratification and Postoperative Outcomes in Endobronchial Tumor Surgery: A Dedicated Center Experience

Matache Radu Șerban, Silviu Gabriel Vlăsceanu, Beatrice Mahler, Alexandru Stoichiță et autres

Background: Endobronchial tumors represent a heterogeneous spectrum of benign and malignant histopathological types. Selecting the optimal surgical strategy remains a multidisciplinary challenge. This study evaluates how the integration of spirometry, DLCO, and CPET can objectively stratify cardiorespiratory risk and guide surgical decision-making …

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From Species Identification to Empirical Therapy: A Machine Learning and Rule-Based Decision Support Framework for Antifungal Resistance Prediction in ICU Candida Infections

Mădălina Preda, Beatrice Mahler, Lia-Mara Ditu, Oana Popescu et autres

Objectives: When a Candida species is identified in an ICU patient, susceptibility results are typically available in 24–72 h. In this study, we built a machine learning model using four variables available at identification to estimate resistance probability in real time. Methods: …

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A Rare Case of Extensive Relapsing Disseminated Hydatid Disease with Multi-Organ Involvement: A Case Report

Silviu Gabriel Vlăsceanu, Matache Radu Șerban, Beatrice Mahler, Adriana-Mihaela Ilieșiu et autres

Background: Hydatid disease, caused primarily by Echinococcus granulosus, remains a significant public health challenge in endemic regions. While hepatic (80–85%) and pulmonary (15–20%) involvements are common, multi-organ dissemination involving rare sites such as the pericardium, diaphragm, and mediastinum occurs in less than …

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Shifting Epidemiology and Antifungal Susceptibility Patterns of Clinical Fungal Isolates in an Intensive Care Unit (ICU) from Bucharest, Romania: A Retrospective Observational Study

Madalina (Preda) Solomon, Beatrice Mahler, Oana Popescu, Lia-Mara Ditu et autres

Background: Antifungal resistance among Candida species represents a growing clinical challenge, particularly in the context of increasing prevalence of non-albicans species. Methods: We conducted a retrospective analysis of 747 fungal isolates collected between 2021 and 2026, evaluating species distribution, antifungal susceptibility profiles, …

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Non-Small-Cell Lung Cancer: From Histopathological Classification to Precision Oncology—A Narrative Review

Simona-Maria Roșu, Viorel Biciuşcă, Sorina Ionelia Stan, Denisa Maria Mitroi et autres

Non-Small-Cell Lung Cancer (NSCLC) represents the most prevalent form of lung cancer and remains one of the leading causes of cancer-related morbidity and mortality worldwide. This disease has evolved far beyond traditional histopathological classification. While histology remains foundational, it is no longer …

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Diabetes Mellitus and COVID-19 in Adults: A Systematic Review of Pathophysiological Connections, Clinical Outcomes, and Therapeutic Considerations

Ioana-Madalina Mosteanu, Oana-Andreea Parliteanu, Beatrice Mahler, Adina Mitrea et autres

The disproportionately severe disease course of diabetic patients with SARS-CoV-2 infection was repeatedly observed by clinicians during the COVID-19 pandemic. The overlap between metabolic impairment, viral pathophysiology, and chronic inflammation created a pattern that urged deeper examination. The aim of this paper …

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A National Multidisciplinary Consensus to Develop an HIV Pre-Exposure Prophylaxis (PrEP) Referral Framework in Romania

Oana Săndulescu, Anca Streinu-Cercel, Anca Streinu-Cercel, Cătălina Poiană et autres

Background: Despite major advances in antiretroviral therapy, HIV transmission remains an important public health challenge. Pre-exposure prophylaxis (PrEP) is a highly effective prevention strategy, offering a significant opportunity to further reduce new HIV infections through expanded access and optimized implementation. Methods: A …

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Evaluation of the functional profile of bronchopulmonary cancer patients based on biomarkers in relation to the International Classification of Functioning, Disability and Health

Tania Ioana Goncea, Mara Amalia Bălteanu, Angela Stefania Marghescu, Beatrice Mahler et autres

Patients with lung cancer commonly report a broad spectrum of symptoms driven by both side effects of treatment and aggressive progression of disease. As a result, growing evidence indicates that pulmonary rehabilitation (PR) can meaningfully improve exercise performance, health-related quality of life …

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A Comprehensive Review of the Association between Sarcopenia and COPD

Tănase Andreea Mădălina, Florentina Gherghiceanu, Beatrice Mahler, Octavian Andronic

COPD is a complex disease with pulmonary and extrapulmonary manifestations intensively studied due to the numerous pathologic processes involved. Its prevalence is increasing, representing the fourth leading cause of mortality worldwide. Sarcopenia can occur in COPD patients with common risk factors. Sarcopenia …

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