Accès ouvert
2025
article
OpenAlex
Charly Abi‐Ghanem, Alex K. Opiela, Aaron S. Paul, Hao Li et autres
BACKGROUND: Up to 80% of Alzheimer's disease (AD) patients suffer from brain vascular damage resulting in multi-etiology dementia (MED). Sex is a well-known risk factor for dementia; out of three AD patients two are women. 17β-estradiol, a predominant ovarian hormone in woman …
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Accès ouvert
2025
article
OpenAlex
Charly Abi‐Ghanem, Richard D. Kelly, Emily Groom, Caitlin G. Valerian et autres
INTRODUCTION: Post-menopausal women constitute about two-thirds of those with Alzheimer's disease (AD). Menopause increases dementia risk by heightening the likelihood of metabolic disease, a well-known risk factor for dementia. We aimed to determine the effects of menopause and high-fat diet (HF) on …
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2024
article
OpenAlex
Luisanna Reinoso Medina, Christina A. Thrasher, Lauren L. Harburger
Several studies report spatial memory decline in old age. However, few studies have examined whether old adults are specifically impaired in allocentric memory tasks (testing for object-to-object spatial location memory). Thus, the present study examined the effects of age on allocentric spatial …
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Accès ouvert
2023
preprint
OpenAlex
Charly Abi‐Ghanem, Abigail E. Salinero, David Riccio, Richard D. Kelly et autres
Abstract About two-thirds of those with Alzheimer’s disease (AD) are women, most of whom are post-menopausal. Menopause accelerates the risk for dementia by increasing the risk for metabolic, cardiovascular, and cerebrovascular diseases. Mid-life metabolic disease (e.g. obesity, diabetes, or prediabetes) is a …
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Accès ouvert
2023
preprint
OpenAlex
Abigail E. Salinero, Charly Abi‐Ghanem, Harini Venkataganesh, Avi Sura et autres
Menopause is a major endocrinological shift that leads to an increased vulnerability to the risk factors for cognitive impairment and dementia. This is thought to be due to the loss of circulating estrogens, which exert many potent neuroprotective effects in the brain. …
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Accès ouvert
2023
article
OpenAlex
Rose M. De Guzman, Zachary J. Rosinger, Krystyna A. Rybka, Jason S. Jacobskind et autres
INTRODUCTION: Corticotropin-releasing factor and its primary receptor (CRFR1) are critical regulators of behavioral and neuroendocrine stress responses. CRFR1 has also been associated with stress-related behavioral changes in postpartum mice. Our previous studies indicate dynamic changes in CRFR1 levels and coupling of CRFR1 …
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2022
article
OpenAlex
Christina A. Thrasher, Lily Otto, Lauren L. Harburger
The aim of this study is to examine the relationship between hormone contraceptive use and menstruation on cognitive performance in young women. The object array task assessed object memory and a mental rotations test assessed spatial ability in women taking hormone contraceptives …
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