Nikola Hájková

Comparison of protein-based and genetic prognostic markers in a large cohort of primary pulmonary and extrapulmonary small cell neuroendocrine carcinoma

Klára Pavlíčková, Jan Hojny, Nikola Hájková, Petr Waldauf et autres

Small cell neuroendocrine carcinomas occur in both pulmonary (SCLC) and extrapulmonary sites (EP-SCNC). Although morphologically similar, they may differ biologically, but these differences are not well characterized. The aim of this study was to compare cohorts of SCLC (n = 215) and …

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Evaluation of DICER1 Immunohistochemistry as a Potential Surrogate for Mutation Status in Ovarian Sex Cord–Stromal Tumors

Kristýna Němejcová, Nikola Hájková, Michaela Kendall Bártů, Adam Šafanda et autres

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HER2 aberration is a potential predictive biomarker for extrapulmonary small cell neuroendocrine carcinoma contrary to small cell lung cancer

Nikola Hájková, Klára Pavlíčková, Jiří Dvořák, Jan Hojny et autres

In this study, we investigated human epidermal growth factor receptor 2 (HER2) aberrations, including gene amplification and mutation, and protein expression in 123 small cell lung carcinomas (SCLC) and 128 extrapulmonary small cell neuroendocrine carcinomas (EP-SCNC) samples. Among the EP-SCNC cohort, HER2 …

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Synchronous mucinous metaplasia and neoplasia of the ovarium and fallopian tube with STK11 and KRAS mutations: a case report

Miroslava Flídrová, Eva Krkavcová, Nikola Hájková, Kristýna Němejcová et autres

Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) is a rare disorder defined as mucinous lesions affecting at least two sites in the female genital tract. We report a case of SMMN-FGT in a Caucasian 65-year-old patient with a …

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Decoding the Molecular Landscape of 262 Uterine Sarcomas: RNA-Seq Clustering of Endometrial Stromal Sarcomas, Uterine Tumors Resembling Ovarian Sex Cord Tumors, and Undifferentiated Uterine Sarcomas With Prognostic Insights

Jan Hojny, Jiří Dvořák, Romana Vránková, Michaela Bártů et autres

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Abstract 4593: Molecular and immunohistochemical classification of extrapulmonary small cell neuroendocrine carcinomas: A study of 181 cases

Radoslav Matěj, Pavel Dundr, Klára Pavlíčková, Marián Švajdler et autres

Abstract Extrapulmonary small cell neuroendocrine carcinoma (EP-SCNC) is a rare malignancy with a poor prognosis. Most patients with EP-SCNC have metastatic disease upon presentation, and their average overall survival (OS) is less than 12 months. Our study aimed to conduct a complex …

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Integrating clinicopathological and molecular data to assess the biological behavior of uterine inflammatory myofibroblastic tumors

Quang Hiep Bui, Michaela Krausová, Nikola Hájková, Jan Hojny et autres

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The Rare Gynecologic Sarcoma Study: Molecular and Clinicopathologic Results of A Project on 379 Uterine Sarcomas

Pavel Dundr, Jan Hojny, Jiří Dvořák, Nikola Hájková et autres

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Correlation between p53 immunoexpression and TP53 mutation status in extrapulmonary small cell neuroendocrine carcinomas and its association with patient survival

Klára Pavlíčková, Jan Hojny, Petr Waldauf, Pavel Dundr et autres

Extrapulmonary small cell neuroendocrine carcinoma (EP-SCNC) is a rare malignancy with a poor prognosis. Despite its morphological similarity to lung small cell carcinomas, its oncogenesis remains uncertain. One hundred and seventy-one EP-SCNC were enrolled in a multicenter study, and all tissue samples …

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Molecular and Immunohistochemical Classification of Extrapulmonary Small Cell Neuroendocrine Carcinomas: A Study of 181 Cases

Klára Pavlíčková, Jan Hojny, Petr Waldauf, Marián Švajdler et autres

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Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway

Adam Šafanda, Nikola Hájková, Michaela Bártů, Marián Švajdler et autres

BACKGROUND: Juvenile granulosa cell tumor (JGCT) of the ovary is a rare tumor with distinct clinicopathological and hormonal features primarily affecting young women and children. We conducted a complex clinicopathological, immunohistochemical, and molecular analysis of five cases of JGCT. METHODS: The immunohistochemical …

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An unusual case of late recurrent adult granulosa cell tumor and mature teratoma arising within the same ovary, confirmed by NGS analysis.

Adam Šafanda, Nikola Hájková, Jan Galko, Michaela Kendall Bártů et autres

Adult granulosa cell tumor is a predominant malignant tumor among ovarian sex cord-stromal tumors, representing approximately 3-5% of all ovarian malignancies and being known for its risk of recurrence with high mortality rate. We present a unique case of a 71-year-old woman …