Moto Fukai

Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers

Yusuke Minami, Siddabasave Gowda B. Gowda, Kengo Shibata, S Sakamoto et autres

Hypothermic machine perfusion (HMP) combined with hydrogen gas has previously been shown to mitigate ischemia-reperfusion injury (IRI) in rat liver, but without full recovery of function. This study examined how hydrogen gas modulates hepatic lipid metabolism during HMP using donation after cardiac …

jp (code pays fourni par la source)

Folate receptor 1 is a stemness trait-associated diagnostic and prognostic marker for hepatocellular carcinoma

Yuto Shiode, Takahiro Kodama, Yu Sato, Ryo Takahashi et autres

BACKGROUND: Hepatocellular carcinoma (HCC) can be classified into several subtypes based on molecular traits, aiding in prognostic stratification. The subtype with a poor prognosis is often associated with stem/progenitor features. This study focused on identifying circulating biomarkers for aggressive HCC. METHODS: We …

us, jp, th (code pays fourni par la source)

265.12: NLRP3 inhibition prevented graft infiltration of inflammatory macrophages leading to long-term graft acceptance in mouse heart transplantation.

Takuya Harada, Ryoichi Goto, Yoshikazu Ganchiku, Agustina Forgioni et autres

Background: Inflammasome complexes including NLRP3 play a central role in ischemia-reperfusion injury in transplantation. Aim. To examine the impact of NLRP3 inhibitior on graft preservation and allo-immune responses in organ transplantation. Methods. BALB/c mice were transplanted with C57BL/6 (B6) cardiac allografts. Grafts …

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Role of Heavy Water in Modified University of Wisconsin Solution for Extended Cold Storage of Rat Liver

Moto Fukai, Kengo Shibata, S Sakamoto, Takahisa Ishikawa et autres

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TCF1highPD-1+Ly108+CD8+ T Cells Are Associated with Graft Preservation in Sensitized Mice Treated with Non–Fc Receptor–Binding CD3 Antibodies

Takuji Ota, Ryoichi Goto, Takuya Harada, Agustina Forgioni et autres

The non-Fc-binding anti-CD3 Ab [anti-CD3F(ab')2] can induce graft acceptance depending on the therapeutic window in a rodent heart transplant model. The delayed protocol allows for early graft infiltration of lymphocytes, which may behave in an inhibitory manner. We investigated the most effective …

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Important Constituents of Heavy Water-containing Solution for Cold Storage and Subsequent Reperfusion on an Isolated Perfused Rat Liver

Moto Fukai, S Sakamoto, Kengo Shibata, Takahisa Ishikawa et autres

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Expression Analysis of Early Metastatic Seeding of Colorectal Cancer

A Sawada, Masafumi Ohira, Kanako C. Hatanaka, Hiroki Matsui et autres

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Exploration of Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved after Circulatory Death

S Sakamoto, Hiroki Bochimoto, Kengo Shibata, Nur Khatijah Mohd Zin et autres

Ex vivo hypothermic machine perfusion (HMP) is a strategy for controlling ischemia-reperfusion injury in donation after circulatory death (DCD) liver transplantation. The pH of blood increases with a decrease in temperature and water dissociation, leading to a decrease in [H+]. This study …

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Combination of Cold Storage in a Heavy Water-Containing Solution and Post-Reperfusion Hydrogen Gas Treatment Reduces Ischemia-Reperfusion Injury in Rat Livers

Moto Fukai, S Sakamoto, Kengo Shibata, Masato Fujiyoshi et autres

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Warm Ischemia Induces Spatiotemporal Changes in Lysophosphatidylinositol That Affect Post-Reperfusion Injury in Normal and Steatotic Rat Livers

Kengo Shibata, Takahiro Hayasaka, S Sakamoto, Satsuki Hashimoto et autres

Warm ischemia-reperfusion injury is a prognostic factor for hepatectomy and liver transplantation. However, its underlying molecular mechanisms are unknown. This study aimed to elucidate these mechanisms and identify the predictive markers of post-reperfusion injury. Rats with normal livers were subjected to 70% …

jp (code pays fourni par la source)

Rapid and Reliable Steatosis Rat Model Shrsp5-Dmcr for Cold Storage Experiment

Moto Fukai, Hiroyuki Sugimori, S Sakamoto, Kengo Shibata et autres

jp (code pays fourni par la source)

Hypothermic Machine Perfusion with Hydrogen Gas Reduces Focal Injury in Rat Livers but Fails to Restore Organ Function

Moto Fukai, S Sakamoto, Hiroki Bochimoto, Nur Khatijah Mohd Zin et autres

jp (code pays fourni par la source)