Visith Sitprija

Distinct pathophysiological mechanisms of Heterometrus laoticus and Lychas mucronatus scorpion venoms on cardiovascular and renal functions

Narongsak Chaiyabutr, Lawan Chanhome, Panithi Laoungbua, Taksa Vasaruchapong et autres

Abstract Background: Heterometrus laoticus and Lychas mucronatus are widely distributed in Southeast Asia, yet their pathophysiological effects of both venoms remain poorly characterized due to low human fatality rates. This study compared their venom compositions and acute cardiovascular and renal effects. Methods: …

th (code pays fourni par la source)

Nephrotoxic acute kidney injury induced by Daboia siamensis venom and its fractions: assessment of Bcl-2 family expression in in vivo and ex vivo in rabbit models

Narongsak Chaiyabutr, Sunutcha Suntrarachun, Suchitra Khunsap, Orawan Khow et autres

Abstract Background: Envenomation by Daboia siamensis venom (RVV) can cause acute kidney injury (AKI), but its mechanisms remain unclear. Renal cell death via necrosis and apoptosis is central to AKI progression. Bax and Bcl-2 are key pro- and anti-apoptotic regulators and common …

th (code pays fourni par la source)

Phospholipase A2 from Daboia siamensis venom induces acute kidney injury: involvement of ion channels in an isolated perfused rabbit kidney model

Narongsak Chaiyabutr, Taksa Vasaruchapong, Panithi Laoungbua, Orawan Khow et autres

Background: Acute kidney injury (AKI) is a serious complication associated with Daboia siamensis envenomation, primarily due to direct nephrotoxicity. This study aimed to investigate the effects of the phospholipase A2 (RvPLA₂) fraction from D. siamensis venom on renal function and to assess …

th (code pays fourni par la source)

Tropical Diseases: A Public Health Problem with Impact on Nephrology

Prit Kusirisin, Visith Sitprija, Nattachai Srisawat

th (code pays fourni par la source)

Acute phase reactions in Daboia siamensis venom and fraction-induced acute kidney injury: the role of oxidative stress and inflammatory pathways in in vivo rabbit and ex vivo rabbit kidney models

Narongsak Chaiyabutr, Jureeporn Noiprom, Kanyanat Promruangreang, Taksa Vasaruchapong et autres

Background: This study examines the direct nephrotoxic effects of Daboia siamensis venom (RVV) and venom fractions in in vivo and isolated perfused kidneys (IPK) to understand the role of inflammation pathways and susceptibility to oxidative stress in venom or fraction-induced acute renal …

th (code pays fourni par la source)

Exploring hospital practice types and their impact on glomerular pathologic patterns: Insights from the largest kidney biopsy cohort in Thailand

Talerngsak Kanjanabuch, Suramath Isaranuwatchai, Tanawin Nopsopon, Theerachai Thammathiwat et autres

BACKGROUND: This study aims to investigate the influence of different kidney biopsy practices on the prevalence of glomerular pathologic patterns in the largest kidney biopsy registry in Thailand. METHODS: We conducted a retrospective review of kidney biopsy records from the period between …

th, us, gb (code pays fourni par la source)

Seroprevalence of leptospirosis among blood donors in an endemic area

Umaporn Limothai, Sasipha Tachaboon, Janejira Dinhuzen, Jasleen Singh et autres

Thailand is known to be endemic for leptospirosis. This bacterium may pose a potential risk to transfusion safety. This study was a cross-sectional study examining the seroprevalence of leptospirosis among Thai blood donors. A total of 1053 serum specimens collected from blood …

th, gb, us (code pays fourni par la source)

Hydrogen peroxide from l-amino acid oxidase of king cobra (Ophiophagus hannah) venom attenuates Pseudomonas biofilms

Uthaibhorn Singkham-in, Wichit Thaveekarn, Jureeporn Noiphrom, Orawan Khow et autres

Abstract Because of the high incidence of Pseudomonas aeruginosa biofilms-related nosocomial infections, venoms from common Thai snakes were tested. Although venoms from king cobra (Ophiophagus hannah; OH) and green pit viper (Trimeresurus albolabris) showed the broadest antibacterial spectrum, OH venom demonstrated more …

th, us (code pays fourni par la source)

Characterizing and applying immunoglobulins in snakebite diagnostics: A simple and rapid venom detection assay for four medically important snake species in Southeast Asia

Louisa Pernee Lee, Choo Hock Tan, Sumana Khomvilai, Visith Sitprija et autres

my, th (code pays fourni par la source)

Long-term kidney outcomes after leptospirosis: a prospective multicentre cohort study in Thailand

Jeerath Phannajit, Tanat Lertussavavivat, Umaporn Limothai, Sasipha Tachaboon et autres

BACKGROUND: Leptospirosis is one of the most important public-health zoonotic diseases in the tropics that can cause severe organ dysfunction and death. Currently there are insufficient data on long-term renal dysfunction in patients after leptospirosis infection. METHODS: A prospective multicentre cohort study …

th (code pays fourni par la source)

Phytochemicals in medicine: Cellular mechanism

Siravit Sitprija, Visith Sitprija

Phytochemicals are basic substances in plants commonly used in traditional medicine. Understanding their mechanisms of action on cellular function is fundamental in pharmacophysiology. This review highlights the effects of phytochemicals starting from the membrane receptors, ion channels and signal transduction leading to …

Acute kidney injury in the tropics

Prit Kusirisin, Geraldo Bezerra da Silva, Visith Sitprija, Nattachai Srisawat

The tropics are a region consisting of more than 125 countries, accounting for 40% of the world's population. The region's population is expected to increase up to 60% in the coming decades. Many tropical countries continue to experience public health problems such …

th, br (code pays fourni par la source)