Synonymous Codon Bias as a Basis for Novel Antibiotic Design: From Nucleotide Wobble Constraint to Ribosomal Garrotte
James H. McKie, Samuel A McKie
0 citationsFuture Medicinal Chemistry
James H. McKie
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30Publications signalées
830Citations signalées
0Affiliations récentes
Domaines associés
Research on Leishmaniasis StudiesDNA and Nucleic Acid ChemistryInsect and Pesticide ResearchPhenothiazines and Benzothiazines Synthesis and ActivitiesTrypanosoma species research and implications
Publications récentes
Peptoid inhibition of trypanothione reductase as a potential antitrypanosomal and antileishmanial drug lead
Cecil Chan, Hong Yin, James H. McKie, Alan H. Fairlamb et autres
17 citationsAmino Acids
Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks
James H. McKie, J. Garforth, Rabih Jaouhari, Cecil Chan et autres
16 citationsAmino Acids
Attempts to understand the molecular and developmental basis of VCFS and DCS
Peter Scambler, Courtney Roberts, James H. McKie, Caro M. Meijers
0 citationsUCL Discovery (University College London)
Synthesis and enzymology of modifiedN-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase fromTrypanosoma crud: Part 3
C-T. Yuen, J. Garforth, T. Besheya, Rabih Jaouhari et autres
3 citationsAmino Acids
Rational Inhibitor Design, Synthesis and NMR Spectroscopic Study by Transferred Nuclear Overhauser Spectroscopy of Novel Inhibitors of Cinnamyl Alcohol Dehydrogenase, a Critical Enzyme in Lignification
Karen Kennedy, Michel Baltas, Kenneth T. Douglas, Hubert Duran et autres
3 citationsJournal of enzyme inhibition
Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs
Cecil Chan, Hong Yin, Jacqui Garforth, James H. McKie et autres
13 citationsJournal of Medicinal Chemistry
Rational Drug Design Approach for Overcoming Drug Resistance: Application to Pyrimethamine Resistance in Malaria
James H. McKie, Kenneth T. Douglas, Cecil Chan, Simon A. Roser et autres
72 citationsJournal of Medicinal Chemistry
Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial Drugs
Cecil Chan, Hong Yin, Jacqui Garforth, James H. McKie et autres
141 citationsJournal of Medicinal Chemistry
Inhibitors of Glutathione Reductase as Potential Antimalarial Drugs Kinetic Cooperativity and Effect of Dimethyl Sulphoxide on Inhibition Kinetics
Rainer M. Lüönd, James H. McKie, Kenneth T. Douglas, Michael J. Dascombe et autres
19 citationsJournal of enzyme inhibition
Rational design of selective ligands for trypanothione reductase fromtrypanosoma cruzStructural effects on the inhibition by dibenzazepines based on imipramine
J. Garforth, Hong Yin, James H. McKie, Kenneth T. Douglas et autres
42 citationsJournal of enzyme inhibition
Predictability of Designing Specific Binding Interactions for DNA Minor Groove Ligands from NMR Spectroscopy and Molecular Modeling: A Copper(II)-Activated DNA Cleaver Based on Hoechst 33258
John A. Parkinson, Seyed Esmaeil Sadat-Ebrahimi, Amanda N. Wilton, James H. McKie et autres
4 citationsBiochemistry
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