Accès ouvert
2022
article
OpenAlex
Linda M. Liau, Keyoumars Ashkan, Steven Brem, Jian Campian et autres
Importance: Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed. Objective: To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with …
us, gb, de, ca
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Accès ouvert
2022
conference-abstract
OpenAlex
Linda M. Liau, Keyoumars Ashkan, Steven Brem, Jian Campian et autres
Abstract BACKGROUND Standard of care (SOC) and patient survival in glioblastoma have changed little in the past 17 years. We evaluated in a phase 3 trial whether adding an autologous tumor lysate-loaded dendritic cell vaccine (murcidencel) to SOC extends survival. Patients and …
us, gb, de
(code pays fourni par la source)
2022
article
OpenAlex
Erin Dunbar, David McCracken, Adam Nowlan, C. Chen et autres
The overarching objective of this multicenter, prospective, observational registry study is to evaluate “real-world” clinical outcomes and patient-reported outcomes measuring safety and efficacy of a permanently implanted device with Cs-131 seeds embedded in a collagen carrier tile for intracranial neoplasms.
us, in, cz
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Accès ouvert
2021
conference-abstract
OpenAlex
Daniela A. Bota, Nicholas Butowski, David Piccioni, Macarena de la Fuente et autres
Abstract Precision medicine is vital for treating many cancers. Lack of valid biomarkers might contribute to the failure of drug therapy for GBM. The Denovo Genomic Marker 1 (DGM1), a novel pharmacogenomic biomarker, has been discovered by a genome-wide screen of patients …
us, cn
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
Erin Dunbar, David McCracken, Adam Nowlan, Clark Chen et autres
Abstract BACKGROUND For patients with operable intracranial neoplasms, there are opportunities to augment local control beyond traditional methods, such as external beam radiation therapy. Brachytherapy, the implantation of radioactive sources into the resection cavity, can be useful in this setting by providing …
us
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Accès ouvert
2021
conference-abstract
OpenAlex
Erin Dunbar, David McCracken, Adam Nowlan, Clark Chen et autres
Abstract Background For patients with operable intracranial neoplasms, there are opportunities to augment local control beyond traditional methods, such as external beam radiation therapy (EBRT),. Brachytherapy, the implantation of radioactive sources into the resection cavity, can be useful in this setting by …
us
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
K. Stuart Lee, M. Sean Peach, Clark C. Chen, Kathryn Dusenbery et autres
TPS2073 Background: Brachytherapy is an efficacious means for radiation delivery in the treatment of a spectrum of central nervous system tumors. Traditional brachytherapy methods have been limited by uneven dose distribution, complicated workflow, extended procedural times, the cost of dedicated equipment, and …
us
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Accès ouvert
2020
conference-abstract
OpenAlex
Caitlin Monson, Megan E. Tipps, Kelsey Jackson, Meghan Tierney et autres
Abstract INTRODUCTION Despite advances in surgical approaches, followed by chemo-radiotherapy protocols, the overall prognosis for patients with glioblastoma remains poor. Clinical trials have demonstrated that the use of low intensity alternating electric fields, known as Tumor Treating Fields (TTFields), via the Optune™ …
us
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Accès ouvert
2020
conference-abstract
OpenAlex
Megan E. Tipps, Meghan Tierney, Caitlin Monson, Kelsey Jackson et autres
Abstract INTRODUCTION Fatigue and sleep disturbances are among the most common side-effects reported by patients with glioblastoma and contribute significantly to the quality-of-life for this population. Non-invasive monitoring of long-term sleep patterns and fatigue levels in this population would allow for comparison …
us
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Accès ouvert
2020
conference-abstract
OpenAlex
Megan E. Tipps, Meghan Tierney, Caitlin Monson, Kelsey Jackson et autres
Abstract INTRODUCTION Clinical trials have demonstrated that the use of low intensity alternating electric fields, known as Tumor Treating Fields (TTFields), via the Optune™ device extends overall survival times in patients with glioblastoma when combined with standard chemotherapy. In addition to survival …
us
(code pays fourni par la source)
Accès ouvert
2019
conference-abstract
OpenAlex
Nilanjana Banerji, Meghan Hultman, Megan E. Tipps, Minda Liu et autres
Abstract INTRODUCTION Standard care for newly diagnosed glioblastoma consists of maximal surgical resection followed by radiotherapy with concurrent and adjuvant temozolomide. Prognosis for glioblastoma still remains poor, with a reported median survival of 14.6 months. Published data indicate that optimal outcomes in …
us
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Accès ouvert
2019
conference-abstract
OpenAlex
Megan E. Tipps, Meghan Hultman, Nilanjana Banerji, Kelsey Jackson et autres
Abstract INTRODUCTION Standard care for glioblastoma consists of maximal surgical resection followed by radiotherapy with concurrent and adjuvant temozolomide. Fatigue and sleep disturbances are among the most common side-effect reported by these patients. Monitoring long-term sleep patterns and fatigue levels in this …
us
(code pays fourni par la source)