Savanah D. Gisriel

The essentials—measurable residual disease in hematopoietic neoplasms: current testing landscape and future directions

Savanah D. Gisriel, Alexa J. Siddon

OBJECTIVES: Measurable residual disease (MRD) analysis, also known as minimal residual disease analysis, has become an essential component of routine clinical management in many hematopoietic neoplasms. Measurable residual disease status in the absence of morphologic disease holds prognostic value and can acutely …

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1190 Acute Erythroid Leukemia Clonally Evolved from Myeloid Neoplasms

Megan J. Fitzpatrick, Ji Yuan, Daniel Akuma, Andrew W. Allbee et autres

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Virus-derived serpin reduces immuno-coagulopathic damage in murine colitis by targeting the urokinase-type plasminogen activator receptor (uPAR) and complement

Alexandra Lucas, Henna Monder, Junior Ayuk Enow, Cheyanne Woodrow et autres

A virus-derived serpin, Serp-1, has proven efficacy in treating inflammatory and coagulation disorders in preclinical and clinical studies. Serp-1 evolved over millions of years to block host immune responses, targeting serine proteases in immune and coagulation pathways. Treatment with PEGylated Serp-1 (PEGSerp-1) …

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Virus-derived Serpin Reduces Immuno-coagulopathic Damage in Murine Colitis by Targeting the urokinase-type Plasminogen Activator Receptor (uPAR) and Complement

Alexandra R Lucas, Henna Monder, Junior Ayuk Enow, Cheyanne Woodrow et autres

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Transcriptional Analysis of Effusion-Based Lymphoma Supports a Post-Germinal Center Origin and Specific Inflammatory Signal Background

Vanessa Pérez‐Silos, Hojung Kim, Chenguang Wang, Alejandro Zevallos-Morales et autres

BACKGROUND: Effusion-based lymphoma (EBL) is a rare and aggressive large B-cell lymphoma. It presents as a body cavity effusion without a solid mass, lacks HHV-8 association, and typically expresses CD20. OBJECTIVES: To better understand the biology of this entity, we performed transcriptomic …

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Concurrent or subsequent lymphomatous effusion in large B-cell lymphoma portends a dismal prognosis: A multi-institutional study

Savanah D. Gisriel, Yuan Ji, Haiming Tang, Jie Xu et autres

OBJECTIVE: Rare large B-cell lymphomas (LBCLs) present with concurrent or subsequent lymphomatous effusion (solid-effusion LBCL, SE-LBCL), which may have an inferior prognosis compared with their noneffusion counterpart. In addition, the relationship between SE-LBCL and human herpesvirus 8-negative effusion-based LBCL (EB-LBCL) remains unclear. …

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Standardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms

Savanah D. Gisriel, Fnu Aakash, John M. Bennett, Robert Paul Hasserjian et autres

CONTEXT.—: Standardized bone marrow reporting specifically for myelodysplastic syndromes/neoplasms (MDS) is currently lacking in the literature and much needed in practice. OBJECTIVE.—: To propose a standardized approach to MDS evaluation in bone marrow specimens by (1) enhancing interinstitutional and intrainstitutional collaborations and …

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Optimization criteria for ordering myeloid neoplasm next‐generation sequencing

Savanah D. Gisriel, John G. Howe, Christopher A. Tormey, Richard Torres et autres

Introduction: Myeloid neoplasms (MNs) frequently harbor pathogenic mutations not detected by karyotyping and fluorescence in situ hybridization; hence, next-generation sequencing (NGS) is necessary for diagnosis, risk stratification, and therapy. If, however, NGS is not clinically indicated but still performed, the results may …

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Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes—Recommendations From the International Consortium for Myelodysplastic Neoplasms/Syndromes (MDS [icMDS])

Fnu Aakash, Savanah D. Gisriel, Amer Methqal Zeidan, John M. Bennett et autres

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Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection

Liqiang Zhang, Yize Li, Karen V. Kibler, Simona J. Kraberger et autres

SARS-CoV-2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti-viral drugs and monoclonal antibodies reduce early COVID-19 severity, but treatments for late-stage immuno-thrombotic syndromes and long COVID are limited. Serine protease inhibitors (SERPINS) regulate activated proteases. …

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Idiopathic myointimal hyperplasia of the mesenteric veins: A systematic review and individual patient data regression analysis

Raquel N. Rozner, Savanah D. Gisriel, John Damianos, Alyssa Ann Grimshaw et autres

BACKGROUND AND AIM: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is an uncommon cause of colonic ischemia for which surgical treatment is typically curative. We describe clinical, radiologic, and endoscopic findings in IMHMV patients to provide clinicians with a framework for …

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Recognizing the microgranular variant of acute promyelocytic leukemia when considering leukapheresis

Savanah D. Gisriel, Po‐Han Chen, Christopher A. Tormey, Alexa J. Siddon

The authors have disclosed no conflicts of interest.

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