Charlotte Dubois

The PERK/Akt Pathway Mediates Apoptosis Resistance to ER Ca2+ Stress in LNCaP Prostate Cancer Cells

Charlotte Dubois, Dheeraj Kannancheri Puthooru, Fabien Vanden Abeele

Selective and targeted sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitors represent a promising and new class of cancer chemotherapeutics that are under investigation in different clinical trials. However, resistance to cancer chemotherapeutics treatments is a common phenomenon and recent evidence suggests that SERCA inhibition …

Role of Orai3 in the Pathophysiology of Cancer

José Sánchez-Collado, Isaac Jardín, José J. López, Victor Ronco et autres

The mammalian exclusive Orai3 channel participates in the generation and/or modulation of two independent Ca2+ currents, the store-operated current, Icrac, involving functional interactions between the stromal interaction molecules (STIM), STIM1/STIM2, and Orai1/Orai2/Orai3, as well as the store-independent arachidonic acid (AA) (or leukotriene …

es, fr (code pays fourni par la source)

Protocols for endothelial cell isolation from mouse tissues: brain, choroid, lung, and muscle

Nadine V. Conchinha, Liliana Sokol, Laure-Anne Teuwen, Koen Veys et autres

Endothelial cells (ECs) harbor distinct phenotypical and functional characteristics depending on their tissue localization and contribute to brain, eye, lung, and muscle diseases such as dementia, macular degeneration, pulmonary hypertension, and sarcopenia. To study their function, isolation of pure ECs in high …

be, cn, dk, fr (code pays fourni par la source)

Protocols for endothelial cell isolation from mouse tissues: kidney, spleen, and testis

Sébastien J. Dumas, Elda Meta, Nadine V. Conchinha, Liliana Sokol et autres

Endothelial cells (ECs) exhibit phenotypic and functional tissue specificities, critical for studies in the vascular field and beyond. Thus, tissue-specific methods for isolation of highly purified ECs are necessary. Kidney, spleen, and testis ECs are relevant players in health and diseases such …

be, cn, fr, us, dk (code pays fourni par la source)

Protocols for endothelial cell isolation from mouse tissues: small intestine, colon, heart, and liver

Liliana Sokol, Vincent Geldhof, Melissa García‐Caballero, Nadine V. Conchinha et autres

Endothelial cells (ECs) from the small intestine, colon, liver, and heart have distinct phenotypes and functional adaptations that are dependent on their physiological environment. Gut ECs adapt to low oxygen, heart ECs to contractile forces, and liver ECs to low flow rates. …

be, cn, dk, fr (code pays fourni par la source)

ORAI3 silencing alters cell proliferation and promotes mitotic catastrophe and apoptosis in pancreatic adenocarcinoma

Charlotte Dubois, Kateryna Kondratska, Artem Kondratskyi, Angela Morabito et autres

fr, ua, lb (code pays fourni par la source)

Episodic Future Thinking in Autism Spectrum Disorder and 22q11.2 Deletion Syndrome: Association with Anticipatory Pleasure and Social Functioning

Clémence Feller, Charlotte Dubois, Stéphan Eliez, Maude Schneider

Episodic future thinking (EFT) has been suggested to underlie anticipatory pleasure (AP), itself known to play a crucial role in social functioning (SF). Both AP and SF are impaired in various clinical populations, including autism spectrum disorders (ASD) and 22q11.2 deletion syndrome …

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De la cacophonie des propositions de lois réformant les infractions sexuelles sur mineurs

Charlotte Dubois, Marthe Bouchet

Co-targeting Mitochondrial Ca2+ Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity

Charlotte Dubois, Artem Kondratskyi, Gabriel Bidaux, Lucile Noyer et autres

Mitochondria are important cell death checkpoints, and mitochondrial Ca 2+ overload is considered as a potent apoptotic intrinsic pathway inducer. Here, we report that this Ca 2+ apoptosis link is largely ineffective in inducing cell-death just by itself and required a concomitant …

fr, gb (code pays fourni par la source)

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Joanna Kalucka, Laura de Rooij, Jermaine Goveia, Kateřina Rohlenová et autres

be, cn, dk (code pays fourni par la source)

Axe AGE-RAGE : conséquences physiopathologiques et inflammaging

Charlotte Dubois, Chantal Fradin, Éric Boulanger

fr (code pays fourni par la source)

Un nouveau rôle non métabolique de la glutamine synthétase au cours de l’angiogenèse

Charlotte Dubois, Guy Eelen, Peter Carmeliet

sponsorship: ERC-2010-AdG|269073, ERC-2016-AdG|743074, Gouvernement Flamand « long-term structural Methusalem, FWO, FWO ‘Krediet aan navorsers’

fr, be (code pays fourni par la source)