Juan Du

LAG3 Gene Therapy Attenuates Autoimmune Uveitis by Regulating the PI3K/Akt Signaling Pathway

Liu Zheng, Jiaojiao Jiang, Qiujin Zhang, Xingyu Su et autres

Purpose: Lymphocyte-activation gene 3 (LAG3) is a critical immune checkpoint molecule, yet its role and mechanisms in autoimmune uveitis remain inadequately understood. This study sought to elucidate the expression dynamics, therapeutic potential, and molecular mechanisms of LAG3 in the context of experimental …

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Breast tumor with giant phyllodes: a case report

Fanshuo Zeng, Liyuan Qian, Juan Du, J X Li et autres

Background: Giant phyllodes tumors are rare and are characterized by rapid growth and abundant vascularity. Intraoperative hemorrhage constitutes a major surgical challenge. This report describes a case of a 36-year-old woman with a giant phyllodes tumor of the breast, along with the …

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Pancreatic Metastasis from Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Mimicking a Pancreatic Neuroendocrine Tumor: A Case Report and Focused Literature Review

Xiang Kong, Fan Tong, Ying Liu, Haochen Tang et autres

Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) of the central nervous system is a rare mesenchymal neoplasm with a propensity for late recurrence and distant metastasis. Pancreatic metastasis from intracranial SFT/HPC is exceptionally uncommon and may mimic primary pancreatic neoplasms, particularly pancreatic neuroendocrine tumor (PanNET). …

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Chalcone-containing dual-targeting PD-L1/tubulin small molecules: a novel approach for cancer immunotherapy

Yingxing Zhou, Jingwei Ding, Shayu An, Lu Wang et autres

Objectives This study aims to identify novel small-molecule inhibitors capable of dual targeting of PD-L1 and tubulin, intending to enhance cancer immunotherapy. Methods A combination of computer-aided virtual screening, molecular docking, homogeneous time-resolved fluorescence (HTRF) assays, tubulin polymerization inhibition assays, and in …

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Research on the Melting Mechanism and Prevention Measures of PT High Voltage Fuses in 10∼35KV Distribution Networks

Fanggang Xu, Mingyu Jing, Juan Du, Rui Li et autres

At present, China's 10-35kV distribution network often adopts a neutral ungrounded system. In the neutral ungrounded system of 10-35kV, the frequent melting of the high-voltage fuse of the potential transformer (PT) seriously affects the safe and reliable operation of the system. To …

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Axillary lymph node dissection offers no survival benefit in breast cancer patients with sentinel lymph node micrometastases after neoadjuvant therapy

Jianing Zhang, Yudong Zhou, Lizhe Zhu, Jiaqi Zhang et autres

The role of axillary lymph node dissection (ALND) in breast cancer patients with sentinel lymph node (SLN) micrometastases, particularly after neoadjuvant therapy, remains debated. The present study aimed to assess whether adding ALND provides a survival benefit in this population. Data were …

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A bibliometric analysis of mechanisms and linkage studies on neurological disorders and statins over the past 20 years

Juan Du, Yiru Li, Chengzhang Yu, Lin Cui et autres

Neurological disorders are one of the major contributors to the burden of disease, affecting the quality of life of the global population.Statins, known for their cholesterol-lowering properties, have garnered substantial interest due to their potential neuroprotective effects and association with subjective cognitive …

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Real-world effectiveness and safety of oral Janus kinase inhibitor in vitiligo: A retrospective study

Xiaoyi Shi, Mengyi Zhu, Juan Du, Xiaolan Ding

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EVALUATING MEDICAL STUDENT ENGAGEMENT IN RADIATION ONCOLOGY: A PROGRAM ASSESSMENT OF A NATIONAL WORKSHOP

Brandon Chai, Aaron Dou, Juan Du, Andrea Bezjak et autres

WITHDRAWN: 385P Is axillary intervention necessary for selected patients with cN0-1 breast cancer after neoadjuvant chemotherapy?

Y. Zhang, Xin Chen, Juan Du

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The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

Ning Gao, Xing Fan, Juan Du, Zhao wenxue et autres

The intramembrane aspartic protease, γ-secretase, is a heterotetrameric protein complex composed of four integral membrane proteins: presenilin (PSEN), nicastrin (NCT), Anterior pharynx defective-1 (APH-1), and presenilin enhancer 2 (PEN-2). These components are sequentially assembled into a functional complex. γ-secretase is ubiquitously expressed …

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Enhancing Medical Student Engagement in Radiation Oncology: Insights from a National Workshop Evaluation

Brandon Chai, Aaron Dou, Juan Du, Andrea Bezjack et autres

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