Si-hui Zhu

Anesthesia/surgery leads to blood-brain barrier disruption via the transcellular and paracellular pathways, and postoperative delirium-like behavior: A comparative study in mice of different ages

Xudong Hu, Lixia Liu, Xin Da, Si-hui Zhu et autres

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Anesthesia/surgery activate MMP9 leading to blood-brain barrier disruption, triggering neuroinflammation and POD-like behavior in aged mice

Yun Hang Hu, Xudong Hu, Ziqing He, Yang Liu et autres

• MMP9 injures tight junctions and pericytes , leading to BBB disruption and POD-like behavior . MMP9 inhibitors can impedes this process, attenuating POD-like behaviors. • MMP9 also promotes endothelial transcytosis , which further leads to BBB disruption. MMP9 inhibitors can reverse …

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Reactive oxygen species contribute to delirium-like behavior by activating CypA/MMP9 signaling and inducing blood-brain barrier impairment in aged mice following anesthesia and surgery

Lifang Liu, Yun Hang Hu, Yinuo Liu, De-Wen Shi et autres

Postoperative delirium (POD) is common in the elderly and is associated with poor clinical outcomes. Reactive oxygen species (ROS) and blood-brain barrier (BBB) damage have been implicated in the development of POD, but the association between these two factors and the potential …

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