Luyao Xie

A longitudinal Health Atlas of age-associated multisystem physiology from population health examinations in China

Shilong Zhang, Qing Yang, Huiyun Pan, Enyan Liu et autres

Routine health examinations capture longitudinal physiology but are seldom used to characterize aging. We constructed a Health Atlas from 94,055,326 observations of 99 biomarkers in 189,095 participants from Zhejiang, organized into ten prespecified domains. Biomarkers and domains followed heterogeneous age trajectories, with …

cn (code pays fourni par la source)

mirCCC: Repression-aware graph learning for miRNA-mediated cell-cell communication inference

Yuehua Chen, Jiaming Cui, Shilong Zhang, Enyan Liu et autres

Abstract Cell–cell communication analyses usually focus on protein ligands and receptors and therefore miss extracellular vesicle transfer of microRNAs, an important route of signalling in cancer. Here we show that microRNA-mediated communication can be inferred from standard single-cell RNA sequencing by detecting …

cn, gb (code pays fourni par la source)

PepAnno: A structure-aware deep learning framework for bioactive peptide prediction, structural visualization, and physicochemical profiling

Enyan Liu, Yueming Hu, Liya Liu, Yifan Chen et autres

Peptides are gaining prominence as therapeutic candidates due to their diverse physiological functions and structural simplicity. Although multiple computational tools exist for bioactive peptide prediction, many suffer from limitations such as non-intuitive interfaces, sequence-only representations, insufficient structural awareness, restricted interpretability, or fragmented …

cn, cu (code pays fourni par la source)

Integrated transcriptomic and proteomic analysis reveals molecular mechanisms of melatonin-regulated hair follicle growth in cashmere goats and comparative insights across goat breeds

Luyao Xie, Chun Li, Jin‐Lei Tian, Shaoyin Fu et autres

BACKGROUND: Cashmere goats are prized for their high-quality fibers, which are soft, fine, strong, and exhibit remarkable elasticity and luster. Cashmere growth occurs in secondary hair follicles and follows a distinct, periodic cycle. This study seeks to offer a more comprehensive understanding …

cn (code pays fourni par la source)

HPInet: Interpretable prediction of Host-Pathogen protein-protein Interactions using a transformer-based neural network

Yueming Hu, Liya Liu, Yanyan Zhu, Enyan Liu et autres

Abstract Gram-negative bacteria utilize a series of secretion systems (T1SS-T10SS) to deliver secreted effector proteins (T1SE-T10SE) into host cells, leading to infections and diseases. Understanding the interactions between these effector proteins and host proteins is crucial for unraveling the pathogenic mechanisms of …

cn, hk (code pays fourni par la source)

Identification of Novel RNAs

Cong Feng, Luyao Xie, Ming Chen

cn (code pays fourni par la source)

Non-coding RNA notations, regulations and interactive resources

Mengwei Cheng, Yi-Zhi Zhu, Yu Han, Linlin Shao et autres

cn, ru (code pays fourni par la source)

ncPlantDB: a plant ncRNA database with potential ncPEP information and cell type-specific interaction

Liya Liu, Enyan Liu, Yueming Hu, Sida Li et autres

The field of plant non-coding RNAs (ncRNAs) has seen significant advancements in recent years, with many ncRNAs recognized as important regulators of gene expression during plant development and stress responses. Moreover, the coding potential of these ncRNAs, giving rise to ncRNA-encoded peptides …

cn (code pays fourni par la source)

Construction of calcium carbonate-liposome dual-film coated mesoporous silica as a delayed drug release system for antitumor therapy

Yuwen Wang, Kun Yu Zhao, Luyao Xie, Kexin Li et autres

cn (code pays fourni par la source)

Successively triggered Rod-shaped protocells for enhanced tumor Chemo-Photothermal therapy

Wei Zhang, Lu Chen, Mingshu Cui, Luyao Xie et autres

cn (code pays fourni par la source)

Design of chiral mesoporous silica nanorods using ursodeoxycholic acid/chenodeoxycholic acid and CTAB as templates for chiral-selective release of achiral drugs

Xue Song Jiang, Mingshu Cui, Wei Zhang, Luyao Xie et autres

cn (code pays fourni par la source)

Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and Applications

Mingshu Cui, Wei Zhang, Luyao Xie, Lu Chen et autres

Because of its tunable textural properties and chirality feature, chiral mesoporous silica (CMS) gained significant consideration in many fields and has been developed rapidly in recent years. In this review, we provide an overview of synthesis strategies for fabricating CMS together with …

cn (code pays fourni par la source)