Genetic and chemical correction of cystic fibrosis reduces airway susceptibility to SARS-CoV-2
S. Rollins, A. Hume, D. W. Chen, Rebecca Yeboah et autres
Using rigorously controlled iPSC-derived airway models, the study shows that CFTR-deficient cells are more vulnerable to SARS-CoV-2 and display stronger inflammation than syngeneic CFTR-corrected controls. The CFTR modulator ETI reduces viral injury and boosts antiviral pathways in both CF and non-CF cells. …
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2 citations
American Journal of Physiology-Lung Cellular and Molecular Physiology