Vasileios Kokkinos

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects

Christopher Cyr, Ania M. Holubecki, Li Shi, Maya Lakshman et autres

Intracranial electrical stimulation (ES) is routinely used therapeutically, diagnostically, and to provide causal evidence in neuroscience studies. However, our understanding of the brain network-level effects of ES remains limited. We applied precision functional mapping (PFM), based on functional magnetic resonance imaging (fMRI), …

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Monosynaptic connections link functionally similar regions in human cortex

Rui Xu, Alan Bush, Atsushi Takahashi, Nathaniel Sisterson et autres

ABSTRACT The functional organization of human cortex has been mapped in considerable detail 1–5 , yet the axonal connections linking these areas remain largely unknown. This gap precludes inferring either the computational pathways through cortical networks or the principles governing why each …

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Pontine hyperperfusion associated with ictal central apnea

Vasileios Kokkinos, Stephen A. VanHaerents, Cody L. Nathan, Dina Ghandour et autres

We report ictal SPECT findings in a patient with focal epilepsy and ictal central apnea (ICA). We describe the history, EEG findings, and SPECT analysis of a 38-year-old female with left posterior quadrant epilepsy post intracerebral hemorrhage due to ruptured aneurysm, whose …

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Sawtooth delta of the thalamus: A physiological variant and the intracranial generator of rapid-eye movement sleep sawtooth waves

Vasileios Kokkinos, Helweh Hussein, Joshua M. Rosenow, Stephan Schuele

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High Accuracy of Epileptic Seizure Detection Using Tiny Machine Learning Technology for Implantable Closed-Loop Neurostimulation Systems

Evangelia Tsakanika, Vasileios Tsoukas, Athanasios P. Kakarountas, Vasileios Kokkinos

Background: Epilepsy is one of the most common and devastating neurological disorders, manifesting with seizures and affecting approximately 1–2% of the world’s population. The criticality of seizure occurrence and associated risks, combined with the overwhelming need for more precise and innovative treatment …

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The localizing value of mimic ictal semiology: A systematic review of the spectrum

Vasileios Kokkinos, Elizabeth Ann Cunningham, Cody L. Nathan, Dina Ghandour et autres

We performed a systematic review of the localization value of ictal mimic automatisms-including gelastic, dacrystic, fearful, ritualistic, and kissing semiology-in focal epilepsy. We performed a comprehensive literature search (Medline, EMBASE, Cochrane, Scopus) for patient-level studies, following a PRISMA and QUADAS2 approach. Patients …

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Introduction. Robotics in the neurosurgical operating room

Peter Vajkoczy, Katharine Jann Drummond, Roger Härtl, Vasileios Kokkinos et autres

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The Posterior Dominant Rhythm Remains Within Normal Limits in the Microgravity Environment

Vasileios Kokkinos, Andreas M. Koupparis, Tomer Fekete, Eran Privman et autres

BACKGROUND: Electroencephalogram (EEG) biomarkers with adequate sensitivity and specificity to reflect the brain's health status can become indispensable for health monitoring during prolonged missions in space. The objective of our study was to assess whether the basic features of the posterior dominant …

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Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I

Vasileios Kokkinos

PURPOSE: This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging. METHODS: Six patients with hyperkinetic seizures type I were evaluated with …

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Aperiodic components of local field potentials reflect inherent differences between cortical and subcortical activity

Alan Bush, Jasmine F Zou, Witold J. Lipski, Vasileios Kokkinos et autres

Information flow in brain networks is reflected in local field potentials that have both periodic and aperiodic components. The 1/fχ aperiodic component of the power spectra tracks arousal and correlates with other physiological and pathophysiological states. Here we explored the aperiodic activity …

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Specific afterdischarge properties can enhance the clinical utility of electrical stimulation mapping during intracranial monitoring

Zachary A. Kons, Vasileios Kokkinos, Amir Hadanny, William Muñoz et autres

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Hippocampal barques and their manifestation as 14&6 Hz positive spikes during sleep

Vasileios Kokkinos, Helweh Hussein, Danai Georgia Sakelliadou, Robert Mark Richardson et autres

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