Guang Shu

Ubiquitination of MEIS1 by MDM2 serves as a switch for p53 stabilization and DNA damage response activation

Jiaxin Liu, Yanxia Duan, Qing Xiao, Shumin Deng et autres

Targeting MDM2 by disrupting its interaction with p53 or inhibiting its E3 ligase activity is a promising strategy to restore p53 functionality. However, achieving anticancer efficacy while minimizing dose-limiting toxicities remains a significant challenge. Moreover, MDM2 also ubiquitinates various non-p53 targets, complicating …

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Predicting prognosis of oral squamous cell carcinoma based on endoplasmic reticulum stress-associated gene signatures

Siqi Li, Weiting Chen, Maonan Wang, Guang Shu et autres

Endoplasmic Reticulum Stress (ERS), as a core mechanism of cellular response to protein homeostasis imbalance, plays a dual regulatory role in tumorigenesis and development. In this study, we aimed to analyze the regulatory network of endoplasmic reticulum stress-associated genes (ERSAGs) in oral …

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Micropeptide YG-6 encoded by exosomal LINC01123 derived from highly migratory ovarian cancer cells promotes tumor progression

Han Lei, Zhengwei Zhou, Chengyuan Li, Lili Fan et autres

BACKGROUND: Intercellular crosstalk plays a pivotal role in tumor progression and metastasis. Exosomes can package long non-coding RNAs (lncRNAs) to mediate extracellular communication. Although exosome research in various cancers has made remarkable progress, it remains unclear in ovarian cancer (OC) whether the …

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Over-Expression of TNFRSF12A Promotes Immune Suppression and Facilitates Angiogenesis in Triple-Negative Breast Cancer

Zhengwei Zhou, Guang Shu, Gang Yin, Maonan Wang

The urgent need for novel therapeutic strategies in triple-negative breast cancer (TNBC)—characterized by absent ER, PR, and HER2 expression—stems from its association with a paucity of effective treatments and an adverse prognosis. This study identifies TNFRSF12A as a key gene specifically overexpressed …

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TNFRSF12A Drives Triple-Negative Breast Cancer Progression via Immune Microenvironment Reprogramming and Facilitated Angiogenesis

Zhenwei Zhou, Guang Shu, Gang Yin, Maonan Wang

The urgent need for novel therapeutic strategies in triple-negative breast cancer (TNBC)—characterized by absent ER, PR, and HER2 expression—stems from its association with a paucity of effective treatments and an adverse prognosis. This study identifies TNFRSF12A as a key gene specifically overexpressed …

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Alternative splicing factor RAB3IP as a novel risk signature to predict the prognosis of colorectal cancer

Zhengwei Zhou, Fei Gao, Lei Han, Haixuan Wen et autres

Emerging evidence suggests that aberrant alternative splicing plays a vital role in the development of tumors. However, the expression of splicing factors (SF) in colorectal cancer and its relationship with prognosis is still unclear. Here, we divided patients into high-risk and low-risk …

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Characterization of Cuproptosis-Related LncRNAs Prognostic Signature and Identification of LINC02285 as a Novel Biomarker for Ovarian Cancer

Zhengwei Zhou, Chang Liu, Weiting Chen, Yu Li et autres

Background: Cuproptosis, a novel form of cell death triggered by copper ion accumulation, has shown potential in cancer therapy, particularly through the involvement of cuproptosis-related lnRNAs (CRLs). In-depth analyses exploring the relationship between CRLs and ovarian cancer (OC) are currently limited. Methods: …

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GJB2 as a novel prognostic biomarker associated with immune infiltration and cuproptosis in ovarian cancer

Ke Guo, Guang Shu, Maonan Wang, Yu Li et autres

Cuproptosis, a recently identified copper-dependent cell death mechanism, remains poorly unexplored in ovarian cancer (OC). This study systematically evaluates clinically significant cuproptosis-related genes (CRGs) as potential prognostic biomarkers in OC. Cox regression analysis and LASSO algorithms were used to develop a prognostic …

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Author response for "Reprogramming of cholesterol metabolism in tumor-associated macrophages"

Qiuping Ma, Ying Zhu, Dongya Zhang, Xiaohan Su et autres

Metabolic reprogramming in cancer and senescence

Yuzhu Zhang, J. Tang, Can Jiang, Hanxi Yi et autres

The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being the aging of the global population. Statistical data show that cancer incidence and mortality rates show a clear upward trend with age. Although there is …

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Reprogramming and targeting of cholesterol metabolism in tumor-associated macrophages

Qiuping Ma, Ying Zhu, Dongya Zhang, Xiaohan Su et autres

Cholesterol, as a major component of cell membranes, is closely related to the metabolic regulation of cells and organisms; tumor-associated macrophages play an important push role in tumor progression. We know that tumor-associated macrophages are polarized from macrophages, and the abnormalities of …

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The Role of the CPT Family in Cancer: Searching for New Therapeutic Strategies

Yong Duan, Jiaxin Liu, Ailin Li, Chang Liu et autres

Along with abnormalities in glucose metabolism, disturbances in the balance of lipid catabolism and synthesis have emerged as a new area of cancer metabolism that needs to be studied in depth. Disturbances in lipid metabolic homeostasis, represented by fatty acid oxidation (FAO) …

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