John‐Peder Escobar Kvitting

Whole-genome sequencing in mitral valve prolapse – an exploratory study on genes associated with mitral valve prolapse and cardiac arrhythmias

Nikhil Arora, Julie Van Den Bergh, Christine Rootwelt‐Norberg, Christian K Five et autres

Abstract Background Mitral valve prolapse (MVP) is a leading cause of mitral regurgitation in high-income countries. Although the course of MVP is often benign, a subset of patients progresses to significant valvular insufficiency, and a smaller subset develops ventricular arrhythmias or sudden …

no (code pays fourni par la source)

Role of valve endothelial cells and extracellular vesicles in aortic valve calcification in vitro

Daria Evensen, Arkady Rutkovskiy, Krizia Sagini, Hanne Haslene‐Hox et autres

Abstract Aortic valve calcification is mediated by valve interstitial cells (VICs). We hypothesized that valve endothelial cells (VECs) stimulate pro-osteogenic changes in VICs, potentially via extracellular vesicles (EVs). We investigated VECs' pro-osteogenic effects on VICs, compared proteomes of healthy versus calcified VECs, …

no (code pays fourni par la source)

The association between soluble ST2 and transplant-free survival in precapillary pulmonary hypertension

Håvard Ravnestad, Salaheldin Ahmed, C.M. Østby, E. Gude et autres

Background: Soluble ST2 (sST2) is a decoy receptor for interleukin-33 and a prognostic biomarker in heart failure, but its utility in precapillary pulmonary hypertension (PH) is not well established. Therefore, we aimed to evaluate the prognostic value of sST2 in patients with …

no, se (code pays fourni par la source)

Dysregulated proteins in plasma distinguishing Loeys–Dietz syndrome from other heritable thoracic aortic disease – an explorative study

Bjørn Edvard Seim, Yusuf Khan, Margrethe Flesvig Holt, Aleksandra Ratajska et autres

Objectives. Thoracic aortic aneurysms (TAAs) are often found in younger individuals and approximately 20% may be associated with heritable thoracic aortic disease (HTAD). There are some data on genomic biomarkers reflecting inflammation and extracellular matrix remodelling in HTAD. However, data that accurately …

Dysregulated proteins in plasma distinguishing Loeys–Dietz syndrome from other heritable thoracic aortic disease – an explorative study

Bjørn Edvard Seim, Yusuf Khan, Margrethe Flesvig Holt, Aleksandra Ratajska et autres

Objectives. Thoracic aortic aneurysms (TAAs) are often found in younger individuals and approximately 20% may be associated with heritable thoracic aortic disease (HTAD). There are some data on genomic biomarkers reflecting inflammation and extracellular matrix remodelling in HTAD. However, data that accurately …

Dysregulated Proteins in Plasma Distinguishing Loeys-Dietz Syndrome from Other Heritable Thoracic Aortic Disease – An Explorative Study

Bjørn Edvard Seim, Yusuf Khan, Margrethe Flesvig Holt, Aleksandra Ratajska et autres

Thoracic aortic aneurysms (TAA) are often found in younger individuals and approximately 20% may be associated with heritable thoracic aortic disease (HTAD). There are some data on genomic biomarkers reflecting inflammation and extracellular matrix remodeling in HTAD. However, data that accurately reflect …

Dysregulated proteins in plasma distinguishing Loeys–Dietz syndrome from other heritable thoracic aortic disease – an explorative study

Bjørn Edvard Seim, Yusuf Khan, Margrethe Flesvig Holt, Aleksandra Ratajska et autres

OBJECTIVES Thoracic aortic aneurysms (TAA) are often found in younger individuals and approximately 20% may be associated with heritable thoracic aortic disease (HTAD). There are some data on genomic biomarkers reflecting inflammation and extracellular matrix remodeling in HTAD. However, data that accurately …

no, gb (code pays fourni par la source)

Heparin Activity Following Titration-Guided Protamine Reversal After Cardiopulmonary Bypass: Impact on Postoperative Bleeding

Mattias Törnudd, Sofia Ramström, John‐Peder Escobar Kvitting, Joakim Alfredsson et autres

OBJECTIVES: To evaluate postoperative residual and reappearing heparin activity after low-dose, titration-guided protamine reversal following cardiopulmonary bypass (CPB) in elective coronary artery bypass grafting (CABG). DESIGN: Prospective, controlled clinical study. SETTING: Single-center university hospital. PARTICIPANTS: Forty adult patients undergoing elective CABG with …

se, no (code pays fourni par la source)

Non-invasive pressure-volume analysis: a novel method for evaluating ventricular function in patients with aortic stenosis

Darijan Ribic, Espen W. Remme, Otto A. Smiseth, Richard J. Massey et autres

Background and aims: Conventional echocardiographic measurements like ejection fraction (EF) and global longitudinal strain (GLS) evaluate left ventricular (LV) function without considering concurrent loading conditions. A more comprehensive characterization of cardiac function and energetics can be achieved through pressure-volume analysis, but its …

no (code pays fourni par la source)

The Role of Valve Endothelial Cells in Aortic Valve Calcification

Daria Evensen, Arsenii Zabirnyk, Krizia Sagini, Hanne Haslene‐Hox et autres

Aortic valve calcification (AVC) is a leading cause of cardiovascular disease, affecting 25% of people over 75 years old. Valve interstitial cells (VICs) play a main role in calcification. Experimentally induced calcification in cultured VICs is a standard model to study AVC …

no (code pays fourni par la source)

Hepatocyte Growth Factor

Margrethe Flesvig Holt, Annika E. Michelsen, A. Fló, Yusuf Khan et autres

BACKGROUND: It is important to reduce diagnostic delays for patients with cardiac amyloidosis (CA). Plasma biomarkers could streamline the diagnostic process and enhance prognostic accuracy. OBJECTIVES: The authors aimed to identify circulating biomarkers capable of differentiating patients with CA from patients with …

no (code pays fourni par la source)

Comparison of Different Osteogenic Media to Induce Aortic Valve Calcification In Vitro

Daria Evensen, Tommy A. Karlsen, Mari‐Liis Kaljusto, John‐Peder Escobar Kvitting et autres

Background Experimentally induced calcification in primary human aortic valve interstitial cells (VICs) is a good in vitro model for studying calcific aortic valve disease. Mesenchymal stem cells (MSCs) may be used as a substitute for VICs. The aims of the present study …

no (code pays fourni par la source)