Dagmar Wilhelm

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

Cyril Djari, Chloé Mayère, A. Caro-Patón Gómez, Herta Ademi et autres

Ovarian organogenesis requires the coordinated specification of supporting and steroidogenic cell lineages from multipotent coelomic epithelium (CE) progenitors. A longstanding question is whether the CE contains transcriptionally distinct, spatially organized progenitor subpopulations with predetermined lineage biases, or whether specification into supporting and …

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NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis

Simon P. Windley, Yasmine Neirijnck, Diana Vidovic, Quenten Schwarz et autres

Successful testis development relies on the coordinated differentiation and assembly of various cell types to establish both endocrine and reproductive functions. The ubiquitin ligase NEDD4 has emerged as a key player in murine testis development, with this enzyme being implicated in gonadal …

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Genetic Mechanisms of Sex Determination

Dagmar Wilhelm, Diana Vidovic, Andrew J. Pask

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Gonadal sex determination in vertebrates: rethinking established mechanisms

Dagmar Wilhelm, Aitana Perea-Gómez, Axel H. Newton, Marie‐Christine Chaboissier

Sex determination and differentiation are fundamental processes that are not only essential for fertility but also influence the development of many other organs, and hence, are important for species diversity and survival. In mammals, sex is determined by the inheritance of an …

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Genes and gene defects affecting gonadal development and sex determination

Dagmar Wilhelm, Stefan Bagheri‐Fam

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NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis

Simon P. Windley, Yasmine Neirijnck, Diana Vidovic, Quenten Schwarz et autres

Abstract Successful testis development relies on the coordinated differentiation and assembly of various cell types to establish both endocrine and reproductive functions. The ubiquitin ligase NEDD4 has emerged as a key player in murine testis development, with this enzyme being implicated in …

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Testicular sex cord–stromal tumors in mice with constitutive activation of PI3K and loss of Pten

Marija Dinevska, Lachlan Mcaloney, Samuel S. Widodo, Gulay Filiz et autres

Testicular tumors are the most common malignancy of young men, and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively activated in about one-third of testicular cancers. To investigate the role of …

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Editorial: Proceedings of the 9th international symposium on the biology of vertebrate sex determination 2023

Talia Hatkevich, Dagmar Wilhelm

al., 2021). In most mammals, sex determination is genetically dictated, initiated by the expression of the testis-promoting gene Sry from the Y chromosome (Koopman et al., 1991;Sinclair et al., 1990). Expression of Sry triggers the differentiation of the testes by activating Sox9 …

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Testicular sex cord–stromal tumors in mice with constitutive activation of PI3K and loss of Pten

Marija Dinevska, Lachlan Mcaloney, Samuel S. Widodo, Gulay Filiz et autres

Abstract Testicular tumors are the most common malignancy of young men and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively activated in about one third of testicular cancers. To investigate the …

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A Human Homozygous HELQ Missense Variant Does Not Cause Premature Ovarian Insufficiency in a Mouse Model

Shabnam Bakhshalizadeh, Anthony D. Bird, Rajini Sreenivasan, Katrina M. Bell et autres

Disruption of meiosis and DNA repair genes is associated with female fertility disorders like premature ovarian insufficiency (POI). In this study, we identified a homozygous missense variant in the HELQ gene (c.596 A>C; p.Gln199Pro) through whole exome sequencing in a POI patient, …

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Proceedings of the 9th International Symposium on the Biology of Vertebrate Sex Determination 2023

Dagmar Wilhelm

Preface to the Special Issue on Ovarian Development

Dagmar Wilhelm, Joan S. Jorgensen

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