Marco Aurélio Sartim

Location-allocation modeling identifies strategic health facilities to expand access to snakebite antivenom in the Brazilian Amazon

Marcos Adriano Garcia Campos, Thiago Augusto Hernándes Rocha, João Vítor Perez de Souza, Letícia Sayuri Murase et autres

Abstract Background Snakebite envenoming is a major cause of preventable death and disability in the Brazilian Amazon, where long distances, sparse roads, and dependence on river transport delay access to antivenom. We developed location-allocation models to identify community health centers that could …

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Animal models in venom and antivenom research: The need to align academic discovery with manufacturing and regulatory expectations

Stuart Ainsworth, Nicholas R. Casewell, Marco Aurélio Sartim, Amy E. Marriott et autres

The study of snake venom toxicity and evaluation of the neutralisation ability of antivenoms and novel therapeutic agents for envenoming has largely relied on animal tests, especially the analysis of the lethal activity of venoms and its neutralisation. In addition, other animal-based …

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Look what you make my tissues do: The role of metalloproteinases and their inhibitors in Bothrops snakebites

Juliana Costa Ferreira Neves, Fábio Magalhães-Gama, Hiochelson Najibe Santos Ibiapina, Kamille Beltrão Seixas et autres

BACKGROUND: Bothrops envenomation induces extensive local tissue destruction and a robust inflammatory response, largely driven by the host's endogenous molecular pathways. Among these, Matrix Metalloproteinases (MMPs), zinc-dependent endopeptidases responsible for extracellular matrix (ECM) degradation, play a central role. The clinical severity of …

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MassIVE MSV000100575 - Proteomic analysis of crotoxin with the objective of protein identification

Marco Aurélio Sartim

Snakebite Envenomations In The Brazilian Amazon: A Little Less Neglected

Jacqueline de Almeida Gonçalves Sachett, Fan Hui Wen, Allyson Guimarães Costa, Felipe Murta et autres

Snakebite envenomations have a disproportionate burden in the Brazilian Amazon compared to other regions of Brazil. Studies conducted in the state of Amazonas show that Bothrops atrox snakebites are the most common, occurring in every municipality of the state. All the 62 …

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Scorpionism in the Amazon: Evidence, Challenges and Actions for Controlling a Neglected Disease

Jacqueline de Almeida Gonçalves Sachett, Fan Hui Wen, Elisângela Aparecida da Silva, Alexandre Vilhena da Silva Neto et autres

Scorpion sting envenomations impose an increasing burden in the Amazon and result in a considerable impact on public health. The genus Tityus accounts for nearly all clinically relevant cases, with T. metuendus, T. silvestris and T. obscurus being responsible for most of …

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Aspidosperma excelsum Benth. (Apocynaceae): ethnomedicinal applications, phytochemistry of indole alkaloids, and pharmacological potential of an Amazonian species

Dayan de Araújo Marques, Jéssica Burlamaque Maciel, André de Lima Barros, Anne Grace Andrade da Cunha Marques et autres

Abstract Aspidosperma excelsum Benth. (Apocynaceae) is an Amazonian medicinal species traditionally used for treating malaria, inflammatory disorders, liver diseases, fever, and other health conditions. Despite growing scientific interest, knowledge regarding this species remains fragmented and complicated by taxonomic inconsistencies involving botanical synonyms. …

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Clinical characteristics and long-term disabilities in children following Bothrops atrox envenomation in Manaus, western Brazilian Amazon

Débora Nery Oliveira, Jady Shayenne Mota Cordeiro, Andrea Gabriela Mota Saraiva, Hiran Sátiro Souza da Gama et autres

Abstract Background: In the Brazilian Amazon, most snakebites are caused by Bothrops atrox. Although pediatric cases are less frequent, children are more vulnerable to severe complications and long-term disabilities. This study aims to describe the clinical profile of B. atrox envenomation in …

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Metabolomic Biomarkers for the Human Diagnosis of Neglected Tropical Diseases: A Systematic Review

Jéssica Burlamaque Maciel, Rebeca Linhares Abreu Netto, Victor Irungu Mwangi, Camila Fabbri et autres

Neglected tropical diseases (NTDs) affect more than 1.6 billion people worldwide and remain major contributors to morbidity, disability, stigma, and poverty. Metabolomics has emerged as a promising approach for investigating disease-associated biochemical alterations and identifying biomarkers for diagnosis, prognosis, and treatment monitoring. …

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Is glucose-6-phosphate dehydrogenase deficiency associated with COVID-19 infection, severity, and death? A cohort study from the Brazilian Amazon

Adila L. B. Dias, Joabi Rocha Nascimento, Jose Diego Brito-Sousa, Marco Aurélio Sartim et autres

BACKGROUND: Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections, including COVID-19. However, clinical evidence remains limited, especially in regions with …

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Snake Venom PLA2 as Anticoagulant Agents: Role of Crotoxin, from Crotalus durissus Rattlesnake, in Hemostasis

Lisele Maria Brasileiro-Martins, Greene Dias Marques, Jéssica Burlamaque Maciel, Márcia Neiva et autres

Snake venoms are rich sources of bioactive molecules that modulate hemostasis and, among these, anticoagulant snake venom phospholipases A2 (sPLA2) are found in a range of snake venoms. Crotoxin (CTX), from the Crotalus durissus rattlesnake, is a heterodimeric PLA2 complex, and literature …

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Strokes following snakebite envenomations: A systematic review and individual patient data meta-analysis

Thiago Ferreira Almeida, Suelen Pereira Priante, Guilherme Pivoto João, Débora Nery Oliveira et autres

BACKGROUND: Snakebite envenomings (SBE) are an important and neglected health issue due to their frequency and potential for severe clinical outcomes. Envenomations can cause local and systemic complications, depending on the snake species, amount of venom injected, comorbidities, timing and use of …

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