Li Tang

PLAGL1 overexpression exacerbates type 1 diabetes by inducing β‐cell apoptosis via oxidative stress‐dependent dual DNA damage and cGAS / STING pathway activation

Cheng Li, Lingyan Qiao, Juan Ge, Sicui Hu et autres

BACKGROUND: Type 1 diabetes mellitus (T1DM) arises from autoimmune destruction of pancreatic β-cells. Pleomorphic adenoma gene-like 1 (PLAGL1) overexpression has been linked to β-cell apoptosis, but molecular mechanisms remain incompletely understood. This study explored whether PLAGL1 exacerbates T1DM by promoting oxidative stress-induced …

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Differential impact of overt and subclinical hypothyroidism on severe postpartum hemorrhage: a retrospective cohort study

Chenning Liu, Yujiao Fu, Yu-Hui Liu, Li Tang et autres

Background The impact of hypothyroidism, which can be divided into overt hypothyroidism and subclinical hypothyroidism, on severe postpartum hemorrhage (SPPH) remains unknown. Methods A total of 34,303 pregnant women from the Third Affiliated Hospital of Guangzhou Medical University between 2016 and 2020 …

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Efficacy and safety of variable-dose metformin as adjunctive therapy to insulin in adolescents with type 1 diabetes mellitus: a systematic review and network meta-analysis

Cheng Li, Lingyan Qiao, Li Tang

BACKGROUND: Adolescent Type 1 Diabetes (T1D) is complicated by insulin resistance, dyslipidemia, and heightened cardiovascular risk. As adjunctive metformin therapy lacks optimized dosing, we conducted a network meta-analysis (NMA) to rigorously assess the dose-dependent efficacy and safety of metformin combined with insulin …

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Ampelopsis grossedentata protects against ethanol-induced acute duodenal injury by inhibiting TNF-triggered caspases-dependent apoptosis in mice

Chao‐Yue Sun, Wanqing Li, Jiajü Lü, Ao-Yue Zhang et autres

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Efficacy of nonsurgical periodontal treatment on patients with periodontitis and type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis

Jun Xu, Yiming Li, Li Tang, Gulinuer Awuti

OBJECTIVE: This study aimed to evaluate the effects of periodontal basic therapy combined with various adjunctive treatments on periodontal inflammation and glycemic control in patients with periodontitis and type 2 diabetes mellitus (T2DM) using network meta-analysis. METHODS: Randomized controlled trials (RCTs) involving …

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Histological Evaluation of Keratinized Gingival Mucosa Following Fibula Flap and DentalImplantation: A Case Report

Jianjia Tang, Donghui Chen, Zhenhua Pang, Hailun Zhou et autres

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A multimodal transformer system for noninvasive diabetic nephropathy diagnosis via retinal imaging

Zheyi Dong, Xiaofei Wang, Sai Pan, Taohan Weng et autres

Differentiating between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD) without a kidney biopsy remains a major challenge, often leading to missed opportunities for targeted treatments that could greatly improve NDRD outcomes. To reform the traditional biopsy-all diagnostic paradigm and avoid unnecessary …

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CircRNA-mediated heterogeneous ceRNA regulation mechanism in periodontitis and peri-implantitis

Hailun Zhou, Rong Xiang, Wenjin Chen, Wenjin Chen et autres

BACKGROUND: Performing a comprehensive study on the differential expression of mRNAs, miRNAs, and circRNAs in the context of peri-implantitis and periodontitis has beneficial advantages to identify unique molecular signatures and pathways that may contribute to our understanding of these conditions. METHODS: Gingival …

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PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS / STING activation

Cheng Li, Lingyan Qiao, Juan Ge, Sicui Hu et autres

Pancreatic β-cell damage mediated by apoptosis is believed to be a main trigger of type 1 diabetes mellitus (T1DM), which is proposed as an organ-specific autoimmune disease mediated by T cells. Nonetheless, the fundamental origins of T1DM remain uncertain. Here, we illustrate …

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Deciphering peri-implantitis: Unraveling signature genes and immune cell associations through bioinformatics and machine learning

Ning Cao, Ziwei Wan, Donghui Chen, Li Tang

Early diagnosis of peri-implantitis (PI) is crucial to understand its pathological progression and prevention. This study is committed to investigating the signature genes, relevant signaling pathways and their associations with immune cells in PI. We analyzed differentially expressed genes (DEGs) from a …

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Recurrent Abdominal Pain Associated With Small Intestinal Edema

Qing Lu, Li Tang, Jinlin Yang

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Doped nanomaterial facilitates 3D printing target plate for rapid detection of alkaloids in laser desorption/ionization mass spectrometry

Chuang Wang, Luyuan Qin, Dongmei Li, Ligang Hu et autres

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