Simon Gompertz

Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT

Graham S. Devereux, Seonaidh C. Cotton, Mintu Nath, Nicola McMeekin et autres

Background Observational studies of people with chronic obstructive pulmonary disease using beta-blockers for cardiovascular disease indicate that beta-blocker use is associated with reduced risk of chronic obstructive pulmonary disease exacerbation. However, at the time this study was initiated, there had been no …

gb (code pays fourni par la source)

Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation

Graham S. Devereux, Seonaidh C. Cotton, Mintu Nath, Nicola McMeekin et autres

Importance: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Observational studies report that β-blocker use may be associated with reduced risk of COPD exacerbations. However, a recent trial reported that metoprolol did not reduce COPD exacerbations …

gb (code pays fourni par la source)

« Les mosaïques de la “maison de Jupiter”. Dans la maison de Jupiter, avec Isis peut-être »

Arnaud Zucker, Sydney H. Aufrère, P. Charvet, A. Collognat et autres

International audience

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Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)

Seonaidh C. Cotton, Graham S. Devereux, Hassan Abbas, Andrew H. Briggs et autres

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity, mortality and healthcare costs. Beta blockers are well-established drugs widely used to treat cardiovascular conditions. Observational studies consistently report that beta blocker use in people with COPD is associated with a …

gb (code pays fourni par la source)

Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)

Seonaidh C. Cotton, Graham S. Devereux, Hassan Abbas, Andrew H. Briggs et autres

gb, us (code pays fourni par la source)

Effect of Noninvasive Respiratory Strategies on Intubation or Mortality Among Patients With Acute Hypoxemic Respiratory Failure and COVID-19

Gavin D. Perkins, Chen Ji, Bronwen A. Connolly, Keith Couper et autres

Importance: Continuous positive airway pressure (CPAP) and high-flow nasal oxygen (HFNO) have been recommended for acute hypoxemic respiratory failure in patients with COVID-19. Uncertainty exists regarding the effectiveness and safety of these noninvasive respiratory strategies. Objective: To determine whether either CPAP or …

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P74 Digital transformation – the beating heart of a modern COPD service

Simon Gompertz, Reece K. Wagstaff, STUART REES, R Colclough

Introduction and Objectives We commenced an early supported discharge (ESD) service for COPD patients in March 2020. We describe the number of patients presenting to our hospital since then, our virtual in-patient multi-disciplinary team (MDT) ward-round and the benefits that this has …

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P129 Getting it right in a digital age – robust patient selection to an early supported discharge service

Robert Colclough, Reece K. Wagstaff, Susan J. Rees, K. Breese et autres

Introduction and Objectives Digital technology with capability for virtual ward consultant clinical supervision, DECAF scoring and a trusted assessor model was used to select patients for early supported discharge (ESD). We present here data on the initial three months of the pilot …

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The impact of embedding trial recruitment into a clinical care pathway

Kay Por Yip, Simon Gompertz, Catherine M. Snelson, Jeremy Willson et autres

Introduction: Care pathways translate clinical guidelines into care processes within a healthcare institution. Traditionally, clinical research is used to inform the evidence base and hence the architecture of such pathways. Where the evidence is unclear, the impact of using such pathways to …

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Increase in recruitment upon integration of trial into a clinical care pathway: an observational study

Kay Por Yip, Simon Gompertz, Catherine M. Snelson, Jeremy Willson et autres

INTRODUCTION: Many respiratory clinical trials fail to reach their recruitment target and this problem exacerbates existing funding issues. Integration of the clinical trial recruitment process into a clinical care pathway (CCP) may represent an effective way to significantly increase recruitment numbers. METHODS: …

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Correction to: Resolution of Persistent COVID-19 After Convalescent Plasma in a Patient with B Cell Aplasia

Emily McKemey, Adrian Matthew Shields, Sian E. Faustini, Harriet J. Hill et autres

gb (code pays fourni par la source)

Resolution of Persistent COVID-19 After Convalescent Plasma in a Patient with B Cell Aplasia

Emily McKemey, Adrian Matthew Shields, Sian E. Faustini, Harriet J. Hill et autres

gb (code pays fourni par la source)