Brenna M. Zimmer

Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance

Asher R. Utz, Linlin Ma, Dalton Hilovsky, Brenna M. Zimmer et autres

• RSK2, p70S6K, and SGK1 phosphorylate UGDH at serine 316 • Phosphomimetic UGDH S316D and phosphodeficient UGDH S316A mutants produce UDP-glucuronate • UGDH S316D elevates hyaluronan and glycan synthesis and impairs glucuronidation • UGDH S316D increases motility, proliferation, spheroid growth, and enzalutamide …

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Recent insights into the implications of UGDH mutations for human developmental disease

H. James Harwood, Brenna M. Zimmer, Asher R. Utz, Joseph Barycki et autres

Congenital disorders of glycosylation are a significant underlying cause of developmental and epileptic encephalopathy (DEE). A subset of these DEE cases results from biallelic variants in the unique, essential gene encoding UDP-glucose dehydrogenase (UGDH). The UGDH enzyme catalyzes two successive NAD+- dependent …

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Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

Brenna M. Zimmer, Joseph Barycki, Melanie A. Simpson

Hyaluronan is a versatile macromolecule capable of an exceptional range of functions from cushioning and hydration to dynamic signaling in development and disease. Because of its critical roles, hyaluronan production is regulated at multiple levels including epigenetic, transcriptional, and posttranslational control of …

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Altered glucuronidation deregulates androgen dependent response profiles and signifies castration resistance in prostate cancer

Brenna M. Zimmer, Michelle Howell, Linlin Ma, Jeffrey R. Enders et autres

// Brenna M. Zimmer 1 , Michelle E. Howell 2 , Linlin Ma 1 , Jeffrey R. Enders 3 , Danielle Lehman 3 , Eva Corey 4 , Joseph J. Barycki 1 , 3 and Melanie A. Simpson 1 , 5 1 …

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Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

Brenna M. Zimmer, Joseph Barycki, Melanie A. Simpson

Regulation of proteoglycan and glycosaminoglycan synthesis is critical throughout development, and to maintain normal adult functions in wound healing and the immune system, among others. It has become increasingly clear that these processes are also under tight metabolic control and that availability …

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Role of UDP-glucose Dehydrogenase in Prostate Cancer Therapeutic Resistance

Brenna M. Zimmer

Prostate cancer is the most frequently diagnosed male cancer and the second leading cause of cancer related death in U.S. men. Treatment of locally advanced and metastatic tumors involves androgen deprivation therapy. Despite this treatment, more aggressive and metastatic tumors recur in …

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential

Brenna M. Zimmer, Michelle Howell, Linlin Ma, Trevor Romsdahl et autres

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Monitoring Water Quality to Demonstrate the Impact of Agricultural Best Management Practices along a Defined Segment of Eagle Creek

Brenna M. Zimmer