Bernhard Niggli

Twenty-year trends in the prevalence of modifiable cardiovascular risk factors in young acute coronary syndrome patients hospitalized in Switzerland

Thabo Mahendiran, André Hoepli, Fabienne Foster‐Witassek, Hans Rickli et autres

AIMS: Modifiable cardiovascular risk factors (RFs) play a key role in the development of coronary artery disease. We evaluated 20-year trends in RF prevalence among young adults hospitalized with acute coronary syndromes (ACS) in Switzerland. METHODS AND RESULTS: Data were analysed from …

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Twenty-Year Trends in the Incidence and Outcome of Cardiogenic Shock in AMIS Plus Registry

Lukas Hunziker, Dragana Radovanović, Raban V. Jeger, Giovanni Pedrazzini et autres

BACKGROUND: Long-term trends of the incidence and outcome of cardiogenic shock (CS) patients are scarce. We analyze for the first time trends in the incidence and outcome of CS during a 20-year period in Switzerland. METHODS AND RESULTS: The AMIS (Acute Myocardial …

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Negative correlation relationship between left ventricular hypertrophy Sokolow-Lyon and body mass in 41 806 Swiss conscripts

Roger Abächerli, Richard Kobza, Bernhard Niggli, Lingchuan Zhou et autres

Correlation Relationship Assessment between Left Ventricular Hypertrophy Voltage Criteria and Body Mass Index in 41,806 Swiss Conscripts

Roger Abächerli, Lingchuan Zhou, Johann‐Jakob Schmid, Richard Kobza et autres

INTRODUCTION: Electrocardiographic criteria for left ventricular hypertrophy (LVH) have been limited by low sensitivity at acceptable levels of specificity. A number of studies have demonstrated that body mass index (BMI) is associated with decreased sensitivity of ECG LVH classification in hypertensive patients. …

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Prevalence of long and short QT in a young population of 41,767 predominantly male Swiss conscripts

Richard Kobza, Markus Roos, Bernhard Niggli, Roger Abächerli et autres

Influence of aldosterone vs endothelin receptor antagonism on renovascular function in liquorice‐induced hypertension

Thomas Quaschning, Frank T. Ruschitzka, Bernhard Niggli, Carolyn Mb Lunt et autres

BACKGROUND: The enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) provides mineralocorticoid receptor specificity for aldosterone by metabolizing glucocorticoids to their receptor inactive 11-dehydro derivatives. Inhibition of 11beta-HSD2 by liquorice-derived glycyrrhizic acid (GA) therefore results in sodium retention and hypertension. The present study investigated …

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Aldosterone Receptor Antagonism Normalizes Vascular Function in 11β-Hydroxysteroid Dehydrogenase Deficient Hypertension

Thomas Quaschning, Frank T. Ruschitzka, Carolyn Mb Lunt, Bernhard Niggli et autres

76 Background: The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD2) provides mineralocorticoid receptor specificity for aldosterone by metabolising glucocorticoids to their receptor inactive 11-dehydro derivatives. The present study investigated the effect of the aldosterone receptor antagonist spironolactone on endothelial function in liquorrhice induced hypertension. Methods: …

Aldosterone Receptor Antagonism Normalizes Vascular Function in 11β-Hydroxysteroid Dehydrogenase Deficient Hypertension

Thomas Quaschning, Frank T. Ruschitzka, Carolyn Mb Lunt, Bernhard Niggli et autres

76 Background: The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD2) provides mineralocorticoid receptor specificity for aldosterone by metabolising glucocorticoids to their receptor inactive 11-dehydro derivatives. The present study investigated the effect of the aldosterone receptor antagonist spironolactone on endothelial function in liquorrhice induced hypertension. Methods: …

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