Patrizia Gazzerro

PRDM Proteins Orchestrate Colorectal Cancer Tumorigenesis

Erika Di Zazzo, Carmela Sorrentino, Monica Rienzo, Donatella Fiore et autres

Colorectal cancer (CRC) is a heterogeneous disease driven by complex genetic, epigenetic, and microenvironmental alterations. Members of the PR domain-containing (PRDM) protein family have emerged as context-dependent regulators of CRC initiation, progression, tumor cell plasticity, immune modulation, and therapeutic response. Accumulating evidence …

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Correction: Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

Mario Abate, Chiara Laezza, Simona Pisanti, Giovanni Torelli et autres

The original version of this Article contained an error in Fig. 2 . Fig. 2 Functional analysis of the role of FDPS in GBMs. ( A,B ) Representative Western blot showing pSTAT3, STAT3, p-AKT, AKT, p-ERK, ERK FDPS and PCNA protein levels …

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siRNA-based Therapeutic Candidate Targeting PRDM2 for Inhibition of Lung Cancer Progression

Sanjay Kumar, Md. Zubbair Malik, Maya Chaturvedi, Mohit Mishra et autres

Abstract Lung cancer is the leading cause of tumor-related fatalities worldwide. The current precision therapies are effective but target only those molecules that are impacted in a minority of lung cancer patients. Positive Regulatory Domain 2 (PRDM2), a member of the PRDM …

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Fluorescently Tagged Poly(methyl methacrylate)s

Fabia Grisi, Rubina Troiano, Donatella Fiore, Patrizia Gazzerro et autres

Plastic pollution is a global problem affecting the environment and, consequently, people’s well-being. Careful and timely end-of-life plastic recycling is certainly a way, albeit a partial one, to remedy the problem. The immediate identification and selection of the different types of plastic …

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Inulin Amphiphilic Copolymer-Based Drug Delivery: Unraveling the Structural Features of Graft Constructs

Carla Sardo, Giulia Auriemma, Carmela Mazzacano, Claudia Conte et autres

In this study, the structural attributes of nanoparticles obtained by a renewable and non-immunogenic “inulinated” analog of the “pegylated” PLA (PEG-PLA) were examined, together with the potential of these novel nanocarriers in delivering poorly water-soluble drugs. Characterization of INU-PLA assemblies, encompassing critical …

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PRDM2 in Cancer: Deciphering the Molecular Orchestra of a Multifunctional Regulator

Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Patrizia Gazzerro et autres

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RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer

Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino et autres

BACKGROUND: Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year survival rate of ~ 45%. PRDM2/RIZ, a member …

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Rimonabant and Cannabidiol Rewrite the Interactions between Breast Cancer Cells and Tumor Microenvironment

Maria Proto, Donatella Fiore, Maurizio Bifulco, Patrizia Gazzerro

The spread of breast cancer to distant sites is the major cause of death in breast cancer patients. Increasing evidence supports the role of the tumor microenvironment (TME) in breast cancers, and its pathologic assessment has become a diagnostic and therapeutic tool. …

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Exploring the putative role of PRDM1 and PRDM2 transcripts as mediators of T lymphocyte activation

Erika Di Zazzo, Monica Rienzo, Amelia Casamassimi, Caterina De Rosa et autres

BACKGROUND: T cell activation and programming from their naïve/resting state, characterized by widespread modifications in chromatin accessibility triggering extensive changes in transcriptional programs, is orchestrated by several cytokines and transcription regulators. PRDM1 and PRDM2 encode for proteins with PR/SET and zinc finger …

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Advances in “adiponcosis”: Insights in the inner mechanisms at the base of adipose and tumour tissues interplay

Cristina Pagano, Erika Di Zazzo, Giorgio Avilia, Beatrice Savarese et autres

The epidemic spread of obesity is nowadays recognized as a global health and economic burden, arising great interest in the scientific community. The rate of adult obesity steadily increases concomitantly with the cancer incidence. As has been comprehensively reported, obesity is included …

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In Vitro Evidence of Statins’ Protective Role against COVID-19 Hallmarks

Donatella Fiore, Maria Proto, Silvia Franceschelli, Maria Pascale et autres

Despite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, received considerable attention due to their pleiotropic effects, encompassing lipid metabolism control and immunomodulatory and anti-thrombotic effects. In COVID-19 patients, statins …

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Modified Adenosines Sensitize Glioblastoma Cells to Temozolomide by Affecting DNA Methyltransferases

Maria Proto, Donatella Fiore, Chiara Piscopo, Chiara Laezza et autres

Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor, and due to its unique features, its management is certainly one of the most challenging ones among all cancers. N6-isopentenyladenosine (IPA) and its analog N6-benzyladenosine (N6-BA) are modified nucleosides endowed …

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