Lesley Larkin

O-52 - A MULTI-COUNTRY OUTBREAK OF HEPATITIS A ASSOCIATED WITH CONSUMPTION OF A FROZEN MIXED BERRY PRODUCT, UNITED KINGDOM AUGUST 2024 – MARCH 2025

Ms Caitlin McCarthy, Tatiana Garcia Vilaplana, Saba Savul, Louisa Ellis et autres

Abstract Background Public Health Scotland (PHS) and UK Health Security Agency (UKHSA) were notified by national reference laboratories of multiple hepatitis A virus (HAV) genotype IB isolates of UKHSA sequence VRD25_HAV017. Objectives Investigations characterised VRD25_HAV017 UK cases, assessed potential sources and informed …

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The Third Study of Infectious Intestinal Disease (IID3 Study) in the Community: Protocol for UK-Based Prospective Cohort Studies Investigating the Disease Burden

Ben W. Rowland, Vanashree Sexton, Aileen C. Mill, Stephen P. Rushton et autres

BACKGROUND: There is a significant hidden burden of infectious intestinal disease (IID) in the UK community, which has increased over time. In the late 2000s, the Second Study of Infectious Intestinal Disease (IID2 study) estimated 17 million IID cases annually in the …

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A comparison of using online market panel members and traditional methods in control recruitment for a case–control study during a national outbreak of STEC O145, United Kingdom

Grace King, Carys Rees, Clare Sawyer, Ann Hoban et autres

Abstract National foodborne outbreaks of gastrointestinal disease often require rapid case–control investigations to identify the source. Online market panels offer a potential alternative to traditional control recruitment. We compared market panel controls to traditional controls in case–control recruitment during a 2024 UK …

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The Third Study of Infectious Intestinal Disease (IID3 Study) in the Community: Protocol for UK-Based Prospective Cohort Studies Investigating the Disease Burden (Preprint)

Ben W. Rowland, Vanashree Sexton, Aileen C. Mill, Stephen P. Rushton et autres

BACKGROUND There is a significant hidden burden of infectious intestinal disease (IID) in the UK community, which has increased over time. In the late 2000s, the Second Study of Infectious Intestinal Disease (IID2 study) estimated 17 million IID cases annually in the …

PATH-SAFE Consortium Recommendations for Genomic Surveillance of Foodborne Diseases, Using Salmonella as an Exemplar

Tim Dallman, Martin C. J. Maiden, Keith A. Jolley, David L. Gally et autres

By Food Standards Agency, Tim Dallman & 47 more. The purpose of this report is to act as a standard reference for methodologies for genomic surveillance of FBD. The recommendations have been developed using non-typhoidal Salmonella as an example.

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Review GIDE -- Restaurant Review Gastrointestinal Illness Detection and Extraction with Large Language Models

Timothy Laurence, Joshua David Harris, Leo Loman, Amy Douglas et autres

Foodborne gastrointestinal (GI) illness is a common cause of ill health in the UK. However, many cases do not interact with the healthcare system, posing significant challenges for traditional surveillance methods. The growth of publicly available online restaurant reviews and advancements in …

Key role of whole genome sequencing in resolving an international outbreak of monophasic Salmonella Typhimurium linked to chocolate products

Valeska Laisnez, Amoolya Vusirikala, Charlotte Salgaard Nielsen, Vera Cantaert et autres

BACKGROUND: In February 2022, the United Kingdom (UK) detected a cluster of monophasic Salmonella Typhimurium based on whole genome sequencing (WGS). Subsequently, several countries reported cases belonging to this cluster. Epidemiological, microbiological and traceability investigations pointed toward a chocolate food business operator …

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Key role of whole genome sequencing in resolving an international outbreak of monophasic Salmonella Typhimurium linked to chocolate products

Valeska Laisnez, Amoolya Vusirikala, Charlotte Salgaard Nielsen, Vera Cantaert et autres

Background: In February 2022, the United Kingdom (UK) detected a cluster of monophasic Salmonella Typhimurium based on whole genome sequencing (WGS). Subsequently, several countries reported cases belonging to this cluster. Epidemiological, microbiological and traceability investigations pointed toward a chocolate food business operator …

Reading in the Postgenomic Age: Race, Discipline, and Bionarrativity in Contemporary North American Literature

Lesley Larkin

To split or to lump : tracing textual metaphors in Siddhartha Mukherjee's The gene: an intimate history -- From HeLa cells to happiness genes : reading and writing life in Rebecca Skloot's The immortal life of Henrietta Lacks and Richard Powers's Generosity: …

An outbreak of Shiga toxin-producing Escherichia coli (STEC) O157:H7 associated with contaminated lettuce and the cascading risks from climate change, the United Kingdom, August to September 2022

Neil H. J. Cunningham, Claire Jenkins, Sarah Williams, Joanna Garner et autres

(STEC) O157 is a food-borne pathogen which causes gastrointestinal illness in humans. Ruminants are considered the main reservoir of infection, and STEC exceedance has been associated with heavy rainfall. In September 2022, a large outbreak of STEC O157:H7 was identified in the …

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Evaluating Large Language Models for Public Health Classification and Extraction Tasks

Joshua David Harris, Timothy Laurence, Leo Loman, Fan Grayson et autres

Advances in Large Language Models (LLMs) have led to significant interest in their potential to support human experts across a range of domains, including public health. In this work we present automated evaluations of LLMs for public health tasks involving the classification …

Presence of phage-plasmids in multiple serovars of Salmonella enterica

Satheesh Nair, Clare R. Barker, Matthew T. Bird, David R. Greig et autres

Evidence is accumulating in the literature that the horizontal spread of antimicrobial resistance (AMR) genes mediated by bacteriophages and bacteriophage-like plasmid (phage-plasmid) elements is much more common than previously envisioned. For instance, we recently identified and characterized a circular P1-like phage-plasmid harbouring …

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