Accès ouvert
2025
article
OpenAlex
Maria Srour, Matthew Hodge, Charles Kwobah, Megan S. McHenry et autres
Background and objectives Sepsis and septic shock are conditions of high mortality across the globe. Despite the efforts of the Surviving Sepsis Campaign, improvements in outcomes for patients with sepsis and septic shock have been mostly seen in high-income countries (HICs), leaving …
us, Kenya
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Maria Srour, Matthew Hodge, Charles Kwobah, Megan S. McHenry et autres
ABSTRACT Background and objectives Sepsis and septic shock are conditions of high mortality across the globe. Despite the efforts of the Surviving Sepsis Campaign, improvements in outcomes for patients with sepsis and septic shock have been mostly seen in high-income countries (HICs), …
us, Kenya
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Florence Jaguga, Philip Kirwa, Benson N. Gakinya, I Manji et autres
BACKGROUND: Alcohol use disorder is prevalent globally and in Kenya, and is associated with significant health and socio-economic consequences. Despite this, available pharmacological treatment options are limited. Recent evidence indicates that intravenous (IV) ketamine can be beneficial for the treatment of alcohol …
Kenya, au
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Sylvia Omulo, Margaret Oluka, Loice Achieng, Eric Osoro et autres
Antimicrobial stewardship encourages appropriate antibiotic use, the specific activities of which will vary by institutional context. We investigated regional variation in antibiotic use by surveying three regional public hospitals in Kenya. Hospital-level data for antimicrobial stewardship activities, infection prevention and control, and …
us, Kenya
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Florida Muro, Furaha S. Lyamuya, Charles Kwobah, John Bollinger et autres
Background: To develop effective antimicrobial stewardship programs (ASPs) for low- and middle-income countries (LMICs), it is important to identify key targets for improving antimicrobial use. We sought to systematically describe the prevalence and patterns of antimicrobial use in three LMIC hospitals. Methods: …
Tanzanie, Kenya, us, lk
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Nicholas I. Paton, Joseph Musaazi, Cissy Kityo, Stephen Walimbwa et autres
BACKGROUND: WHO guidelines recommend dolutegravir plus two nucleoside reverse transcriptase inhibitors (NRTIs) for second-line HIV therapy, with NRTI switching from first-line tenofovir to zidovudine. We aimed to examine whether dolutegravir is non-inferior to darunavir, the best-in-class protease inhibitor drug, and whether maintaining …
sg, gb, Ouganda, Zimbabwe, Kenya
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Robert Rolfe, Charles Kwobah, Florida Muro, Anushka Ruwanpathirana et autres
BACKGROUND: Antimicrobial resistance has been named as one of the top ten threats to public health in the world. Hospital-based antimicrobial stewardship programs (ASPs) can help reduce antimicrobial resistance. The purpose of this study was to determine perceived barriers to the development …
us, Kenya, Tanzanie, lk
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Sylvia Omulo, Margaret Oluka, Loice Achieng Ombajo, Eric Osoro et autres
Background: Antibiotics are the most prescribed medicines worldwide, accounting for 20%–30% of total drug expenditures in most settings. Antimicrobial stewardship activities can provide guidance for the most appropriate antibiotic use. Objective: In an effort to generate baseline data to guide antimicrobial stewardship …
us, Kenya
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Robert Rolfe, Florida Muro, Furaha S. Lyamuya, Charles Kwobah et autres
Abstract Background Antimicrobial stewardship programs (ASPs) are being developed internationally to mitigate the misuse of antimicrobials. An understanding of current practices and prescribing patterns is necessary to determine targets to develop context-specific ASPs in low- and middle-income country (LMIC) hospitals. Methods We …
us, Tanzanie, Kenya, lk
(code pays fourni par la source)
Accès ouvert
2020
conference-abstract
OpenAlex
Robert Rolfe, Charles Kwobah, Florida Muro, Anushka Ruwanpathirana et autres
Abstract Background Antimicrobial resistance has been named as one of the top ten threats to health in the world. The World Health Organization has endorsed the implementation of hosptial-based antimicrobial stewardship programs (ASPs) to reduce antimicrobial resistance. We conducted a qualitative study …
us, Kenya, lk, Tanzanie
(code pays fourni par la source)
2019
conference-abstract
OpenAlex
Lindsay Boole, Wangari Waweru-Siika, Charles Kwobah, Gerald S. Bloomfield et autres
RATIONALE Fluid resuscitation for sepsis in sub-Saharan Africa (SSA) is controversial. Previous clinical trials of protocol-based sepsis resuscitation for adults in SSA yielded conflicting results, with one showing improved mortality and two others showing harm. A widely used guideline for resuscitation of …
us, Kenya
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
JA Thompson, Cissy Kityo, David Dunn, Anne Hoppé et autres
BACKGROUND: Limited viral load (VL) testing in human immunodeficiency virus (HIV) treatment programs in low-income countries often delays detection of treatment failure. The impact of remaining on failing protease inhibitor (PI)-containing regimens is unclear. METHODS: We retrospectively tested VL in 2164 stored …
gb, Ouganda, ca, Zimbabwe, Malawi, es, sg
(code pays fourni par la source)