2026
conference-abstract
OpenAlex
Abdul Basit Musah, Liangzhe Wu, Edem Bokoe, Bowen Hou et autres
Abstract Introduction T cells, particularly CD8+ T cells, play a central role in immune defense against intracellular pathogens and in tumor immunosurveillance. However, within tumors, these cells often become functionally exhausted, limiting the effectiveness of T cell—based immunotherapies. To maintain self-tolerance and …
us, sg
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Accès ouvert
2026
article
OpenAlex
Edem Bokoe, Abdul Basit Musah, Vivian Jia Yi Tan, Bowen Hou et autres
Abstract Introduction T-cell exhaustion is a critical roadblock to achieving durable remission with adoptive cell therapies. The immunosuppressive tumor microenvironment limits T-cell persistence and function, demanding new reprogramming techniques. Our genome-wide CRISPR screen in CD8+ T cells identified NOX1 as a novel, …
us, sg
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Accès ouvert
2023
article
OpenAlex
Stephen Osei-Wusu, John K. A. Tetteh, Abdul Basit Musah, Desmond Opoku Ntiamoah et autres
Background The epidemiology of Mycobacterium tuberculosis complex (MTBC) lineage 5 (L5) infections in Ghana revealed a significantly increased prevalence in Ewes compared to other self-reported ethnic groups. In that context, we sought to investigate the early phase of tuberculosis (TB) infection using …
Ghana, ch, de
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Accès ouvert
2023
article
OpenAlex
Isaac Darko Otchere, Portia Abena Morgan, Prince Philip Ankapong Asare, Stephen Osei-Wusu et autres
Background Resistance to tuberculosis (TB) drugs has become a major threat to global control efforts. Early case detection and drug susceptibility profiling of the infecting bacteria are essential for appropriate case management. The objective of this study was to determine the drug …
Ghana, ch
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Accès ouvert
2022
article
OpenAlex
Theophilus Afum, Diana Asema Asandem, Prince Philip Ankapong Asare, Adwoa Asante-Poku et autres
Diarrheal disease remains a major global health problem particularly in children under 5 years and the emergence of antibiotic-resistant strains of causative pathogens could slow control efforts, particularly in settings where treatment options are limited. This surveillance study conducted in Ghana aimed …
Ghana, jp, us
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Accès ouvert
2021
article
OpenAlex
Theophilus Afum, Prince Philip Ankapong Asare, Adwoa Asante-Poku, Isaac Darko Otchere et autres
BACKGROUND: Tuberculosis (TB) and COVID-19 pandemics are both diseases of public health threat globally. Both diseases are caused by pathogens that infect mainly the respiratory system, and are involved in airborne transmission; they also share some clinical signs and symptoms. We, therefore, …
Ghana
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Accès ouvert
2021
article
OpenAlex
Stephen Osei-Wusu, Portia Abena Morgan, Prince Philip Ankapong Asare, Godfrey Adams et autres
Studies have shown an association between bacterial load and virulence; however, not much is known about the diversity in this phenotypic characteristic of Mycobacterium tuberculosis complex (MTBC). This study was therefore aimed to determine the differences in bacterial load of the three …
Ghana, gb
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Accès ouvert
2021
article
OpenAlex
Ana Almeida, M. Adjuntsov, W. Bushura, Enrique Delgado et autres
BACKGROUND: WHO drug-resistant TB (DR-TB) treatment recommendations now emphasize all-oral regimens, recommending against certain injectable agents and deprioritizing others due to inferior safety and efficacy. Despite increasing focus on patient-centered care, we are not aware of systematic attempts to qualitatively document patients' …
us, ch, nl
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Accès ouvert
2021
article
OpenAlex
Stephen Osei-Wusu, Isaac Darko Otchere, Portia Abena Morgan, Abdul Basit Musah et autres
Findings from previous comparative genomics studies of the Mycobacterium tuberculosis complex (MTBC) suggest genomic variation among the genotypes may have phenotypic implications. We investigated the diversity in the phenotypic profiles of the main prevalent MTBC genotypes in West Africa. Thirty-six whole genome …
Ghana, ch
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