Angel R. Fuentes‐Pesquera

Abstract 2456: Discovery of orally active 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes with dual EGFR and HER2 inhibitory activity.

Peter J. Connolly, Mary Adams, Amanda K. Beck, Stuart L. Emanuel et autres

Abstract Growth factor receptors of the ErbB family, especially ErbB1 (EGFR) and ErbB2 (HER2), have attracted considerable attention in recent years as therapeutic targets for the treatment of numerous malignancies including cancers of the lung, colon, and breast, either through blockade of …

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A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo

Kenneth R. LaMontagne, Jeannene Butler, Virna Borowski, Angel R. Fuentes‐Pesquera et autres

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Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Ronghui Lin, Sigmond G. Johnson, Peter J. Connolly, Steven K. Wetter et autres

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7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

Terry V. Hughes, Stuart L. Emanuel, Harold R. O’Grady, Peter J. Connolly et autres

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4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors

Guozhang Xu, M.C. Abad, Peter J. Connolly, Michael P. Neeper et autres

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Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases

Guozhang Xu, Lily L. Searle, Terry V. Hughes, Amanda K. Beck et autres

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Design, Synthesis, and Evaluation of 3,4‐Disubstituted Pyrazole Analogues as Antitumor CDK Inhibitors.

Ronghui Lin, George Chiu, Yang Yu, Peter J. Connolly et autres

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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Cellular and in Vivo Activity of JNJ-28871063, A Nonquinazoline Pan-ErbB Kinase Inhibitor That Crosses the Blood-Brain Barrier and Displays Efficacy against Intracranial Tumors

Stuart L. Emanuel, Terry V. Hughes, Mary Adams, Catherine A. Rugg et autres

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Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors

Ronghui Lin, George Chiu, Yang Yu, Peter J. Connolly et autres

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Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents

Ronghui Lin, Peter J. Connolly, Yanhua Lü, George Chiu et autres

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4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation

Terry V. Hughes, Stuart L. Emanuel, Amanda K. Beck, Steven K. Wetter et autres

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Synthesis and biological study of 2-amino-4-aryl-5-chloropyrimidine analogues as inhibitors of VEGFR-2 and cyclin dependent kinase 1 (CDK1)

Shenlin Huang, Ronghua Li, Peter J. Connolly, Stuart L. Emanuel et autres

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