Shengjun Ji

Integrative pan-cancer and COAD-focused multi-omics analysis of non-histone acetylation substrate-related transcriptional landscapes

Jiahao Zhu, Jiyun Shi, Peipei Shen, Rui Lou et autres

Non-histone acetylation regulates protein stability, transcription, and immune signaling, yet its substrate-specific roles in colon adenocarcinoma (COAD) remain unclear. We performed an integrative multi-omics analysis to characterize acetylation substrate-related transcriptional signatures and their clinical relevance. Expression patterns and prognostic impacts of 33 …

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HALP outperforms systemic inflammatory biomarkers for prognosis in locally advanced cervical cancer treated with concurrent chemoradiotherapy

Xun Zhang, Yilin Yin, Tiantian Yang, Yawen Cong et autres

Patients with locally advanced cervical cancer (LACC) treated with concurrent chemoradiotherapy (CCRT) show substantial heterogeneity in survival outcomes, whereas the comparative prognostic value of systemic inflammatory and nutritional biomarkers remains unclear. This study aimed to compare pretreatment inflammatory biomarkers, identify the most …

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HALP score outperforms systemic inflammatory biomarkers for prognosis in locally advanced rectal cancer

Peipei Shen, Tiantian Yang, Yawen Cong, Bin Zhang et autres

The prognostic value of systemic inflammatory and nutritional biomarkers in patients with locally advanced rectal cancer (LARC) remains inadequately defined. This multicenter retrospective study comprehensively assessed the prognostic performance of twelve inflammation-based indices, aiming to identify the most informative biomarker for patients …

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Correction to “Radiotherapy-Potentiated Oncolytic Virotherapy via Iron-Based Metal Organic Framework with Enhanced Ferroptosis”

Aidi Gao, Jundong Zhou, K. F. Xu, Shengjun Ji et autres

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Radiotherapy-Potentiated Oncolytic Virotherapy via Iron-Based Metal Organic Framework with Enhanced Ferroptosis

Aidi Gao, Jundong Zhou, Kaiyue Xu, Zhengcao Liu et autres

Oncolytic viruses (OVs) represent a promising approach for cancer therapy, but their clinical efficacy is often hindered by pre-existing antiviral immunity and tumor drug resistance. To overcome these obstacles, we developed an iron-based metal–organic framework (MOF Fe ) nanoplatform for OV delivery, …

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A Multicenter Study of Systemic Inflammatory Biomarkers for Prognostic Evaluation in iCCA Patients

Yun Tao, Benjie Xu, Jie Tang, Shengjun Ji et autres

Background: The prognostic value of systemic inflammatory biomarkers in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. This study aimed to compare their predictive performance and identify the most effective indicator. Methods: We retrospectively analyzed 312 iCCA patients who underwent curative resection at three medical …

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Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

Jiahao Zhu, Benjie Xu, Rui Hu, Bo Yang et autres

This study introduces the Sono@NAT10 nanorobot for colorectal cancer (CRC) immunotherapy, designed to target NAT10 condensates in macrophages. Sono@NAT10, enclosed in a macrophage membrane using a metal-organic framework, shows stability under acidic conditions and releases NAT10 siRNA upon ultrasound activation. Flow cytometry …

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Sub-regional radiomics combining multichannel 2-dimensional or 3-dimensional deep learning for predicting neoadjuvant chemo-immunotherapy response in esophageal squamous cell carcinoma: a multicenter study

Benjie Xu, Tiantian Fan, Shengjun Ji, Ke Gu et autres

This study aimed to develop and compare fusion models combining sub-regional radiomics with multichannel 2D and 3D DL to predict pCR in patients with LA-ESCC undergoing NACI. A total of 271 patients from three hospitals were divided into training, internal validation, and …

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Amuc_1434 From Akkermansia muciniphila Enhances CD8 + T Cell‐Mediated Anti‐Tumor Immunity by Suppressing PD ‐ L1 in Colorectal Cancer

Jiahao Zhu, Shaolei Qin, Ruike Gu, Shengjun Ji et autres

Colorectal cancer (CRC) shows a limited response to programmed death-ligand 1 (PD-L1) immunotherapies. Akkermansia muciniphila (AKK) may enhance tumor immunity. This study examines how its Outer Membrane Vesicles (OMVs) and Amuc_1434 influence PD-L1 expression and CD8+ T cell activity in CRC. OMVs …

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Lymphocyte-to-C-reactive protein ratio predicts prognosis in unresectable locally advanced non-small cell lung cancer patients

Yingying Xu, Jinping Li, Xiang Ji, Qingqing Chen et autres

Background The lymphocyte-to-C-reactive protein ratio (LCR) is a promising inflammation-based tool for assessing the status of patients with malignant tumours. This study evaluated the ability of LCR to predict the prognosis of patients with unresectable locally advanced non-small cell lung cancer (LA-NSCLC) …

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Integrative analysis of semaphorins family genes in colorectal cancer: implications for prognosis and immunotherapy

Jiahao Zhu, Benjie Xu, Zhixing Wu, Zhiwei Yu et autres

Background Semaphorins (SEMAs), originally identified as axon guidance factors, have been found to play crucial roles in tumor growth, invasiveness, neoangiogenesis, and the modulation of immune responses. However, the prognostic value of SEMA-related genes in colorectal cancer (CRC) remains unclear. Methods We …

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Sub-Regional Radiomics Combining Multichannel 2-Dimensional or 3-Dimensional Deep Learning For Predicting Neoadjuvant Chemo-Immunotherapy Response in Esophageal Squamous Cell Carcinoma: A Multicenter Study

Benjie Xu, Tiantian Fan, Shengjun Ji, Ke Gu et autres