Vasile Stupar

Ultrasound-assisted gene therapy mitigates Leigh syndrome pathology

Mathilde Faideau, Romain Clément, Sébastien Rigollet, Giorgia Benegiamo et autres

Leigh syndrome (LS) is a fatal neurometabolic disease caused by mutations in genes involved in mitochondrial energy harvesting. While there is currently no cure for this disease, pre-clinical studies showed that gene therapy can afford a therapeutic benefit in a relevant model …

fr, us, ch (code pays fourni par la source)

Estimating blood oxygen saturation through susceptibility source separation: A new standpoint on quantitative BOLD models

Lucie Chalet, Sébastien Rigollet, Vasile Stupar, Aurélien Delphin et autres

MR methods have been proposed to estimate blood oxygen saturation in cerebral tissues by exploiting the magnetic susceptibility difference between oxy and deoxyhemoglobin. These models neglect the contribution of extravascular susceptibility sources leading to inaccurate measurements. Recent approaches combined quantitative BOLD and …

fr, it (code pays fourni par la source)

Estimating blood oxygen saturation through susceptibility sources separation: a new standpoint on quantitative BOLD models

Lucie Chalet, Sébastien Rigollet, Vasile Stupar, Aurélien Delphin et autres

Motivation: MR methods have been proposed to estimate blood oxygen saturation (SO2) in cerebral tissues by exploiting the magnetic susceptibility difference between oxy and deoxyhemoglobin. These models neglect the contribution of extravascular susceptibility sources leading to inaccurate measurements. Goal(s): Recent approaches tried …

Microvascular and astrocytic responses to repeated magnetic resonance-guided focused ultrasound

Sébastien Rigollet, Aurélien Delphin, Lucie Chalet, Thomas Ador et autres

Focused ultrasound (FUS), in combination with microbubbles, enables the transient and localized opening of the blood-brain barrier (BBB) for targeted drug delivery. While this technique has shown promise in preclinical models, the safety and neurovascular consequences of repeated BBB permeabilization remain incompletely …

fr, it (code pays fourni par la source)

Mapping GABA+/Glx in experimental temporal lobe epilepsy using edited-MRSI at 9.4T

Alicia Plaindoux, Yann Le Fur, Clothilde Courivaud, Camille Beets et autres

Mesial temporal lobe epilepsy (MTLE) is a common drug-resistant epilepsy, often requiring surgery to remove the epileptogenic zone (EZ). The mean efficiency of the surgery is 50-70 %, so the accurate spatial localization of the EZ remains a challenge. In a previous …

fr (code pays fourni par la source)

Evaluating Behavioral Outcomes of Whole-Brain AAV9 Gene Therapy for Fragile X Syndrome via Focused Ultrasound and BBB Opening

Thomas Ador, Sébastien Rigollet, Vasile Stupar, Anthony Laugeray et autres

International audience

Ultrasound-Assisted Blood–Brain Barrier Opening Monitoring by Photoacoustic and Fluorescence Imaging Using Indocyanine Green

Thomas Ador, Mylène Fournié, Sébastien Rigollet, Claire Counil et autres

OBJECTIVE: The blood-brain barrier (BBB) is a selectively permeable membrane that restricts drug delivery to the central nervous system. Focused ultrasound (FUS) combined with microbubbles (MBs) is a promising technique to transiently open the BBB, enabling therapeutic delivery. However, real-time monitoring of …

fr (code pays fourni par la source)

Longitudinal study tracking physiological changes through multiparametric MRI during repeated MRgFUS-induced BBB opening

Sébastien Rigollet, Thomas Ador, Erik Dumont, Chantal Pichon et autres

Motivation: Long-term delivery of therapeutic agents via repeated MRgFUS is an innovative approach for enhancing glioblastoma treatment but underlying mechanisms are not well documented. Goal(s): Find the best strategy for long-term drug delivery after multiple MRgFUS mediated BBB opening. Approach: Repeated MRgFUS …

GABA spectroscopic imaging at 9.4T to localize the epileptogenic zone in an animal model of focal epilepsy

Alicia Plaindoux, Yann Le Fur, Jia Guo, Clothilde Courivaud et autres

A surgical resection of the epileptogenic zone (EZ) can be proposed to drug-resistant epileptic patients, mainly suffering from focal epilepsy, in order to free them from their seizures. However, the mean efficiency of surgery is around 50 to 80%, indicating a possible …

EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures

Petteri Stenroos, Isabelle Guillemain, Federico Tesler, Olivier Montigon et autres

In patients suffering absence epilepsy, recurring seizures can significantly decrease their quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized by spike-and-wave discharges on the electroencephalogram associated with a transient alteration of consciousness. However, it is still unknown …

fr, fi (code pays fourni par la source)

Author response: EEG-fMRI in awake rat and whole-brain simulations show decreased brain responsiveness to sensory stimulations during absence seizures

Petteri Stenroos, Isabelle Guillemain, Federico Tesler, Olivier Montigon et autres

fr (code pays fourni par la source)

Reviewer #3 (Public Review): How Absence Seizures Impair Sensory Perception: Insights from Awake fMRI and Simulation Studies in Rats

Petteri Stenroos, Isabelle Guillemain, Federico Tesler, Olivier Montigon et autres

In patients suffering absence epilepsy, recurring seizures can significantly decrease their quality of life and lead to yet untreatable comorbidities. Absence seizures are characterized by spike-and-wave discharges on the electroencephalogram associated with a transient alteration of consciousness. However, it is still unknown …