Xueshuai Ye

Cardiomyocytes upregulated PD-L1 expression to alleviate cardiac injury induced by irradiation combined with anti-PD-1 antibody: an in vitro and in vivo study

Ye Zhou, Yajing Wu, Na Zhang, Shuo Wang et autres

Objective: Preclinical studies suggest that irradiation combined with anti-PD-1 antibody (iRT) exacerbates cardiac injury in mice, partly through CD8⁺ T-cell-mediated mechanisms. We investigated radiation-induced PD-L1 expression in cardiomyocytes and explored its potential role in iRT-associated cardiac injury. Methods: AC16 cells were exposed …

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Single cell and bulk transcriptomic analyses support patient specific malignant cell state remodeling after neoadjuvant therapy in locally advanced rectal cancer

Guoqiang LIU, Yonggang YU, Fei Liu, Zexian Fu et autres

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A polysaccharide-rich preparation from Moutan Cortex alleviates non-alcoholic fatty liver disease by ameliorating intestinal flora and bile acid metabolism

Huanhuan Zhang, Hongwei Zhang, Xueshuai Ye, Jing Yang et autres

BACKGROUND: Moutan Cortex (MC), the dried root bark of Paeonia × suffruticosa Andrews, is used as both a medicinal and edible product and possesses hepatoprotective and anti-inflammatory properties. It is rich in bioactive polysaccharide components. However, the role of a polysaccharide-rich preparation …

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NR4A1 mediates chemotherapy‑induced senescence via the PI3K/AKT pathway in gastric cancer cells

T. Zhang, Yue Chong Wang, Jiuna Zhang, Xueshuai Ye et autres

Gastric cancer (GC) remains among the cancers with extremely high morbidity and mortality rates worldwide, and chemotherapy resistance limits its therapeutic efficacy. Therapy‑induced senescence (TIS) is vital for inducing chemotherapy resistance and promoting tumor progression, highlighting the need to explore its regulatory …

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The effect and mechanism of CXCL9 overexpressed umbilical cord mesenchymal stem cells on liver fibrosis in vivo and in vitro

Yang Li, Xueqian Zhang, Guiyu Liu, Tianci Tang et autres

BACKGROUND: Umbilical cord mesenchymal stem cells (UC-MSCs) transplantation has emerged as a promising therapeutic approach of liver fibrosis. However, UC-MSCs have limited anti-fibrotic ability for various reasons. In this study, we aimed to investigate whether the overexpression of CXCL9 in UC-MSCs (CXCL9-UC-MSC) …

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CD19 -targeted CAR T therapy treating hematologic malignancies: hidden danger is the next neighbor to security?

Xueshuai Ye, Min Ge, M. Tan, Yongqiang Wu et autres

CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has achieved marvelous results in the treatment of patients with relapsed and/or refractory B-cell lymphomas, B-cell acute lymphoblastic leukemia, and multiple myeloma. As a new treatment method that has changed the existing treatment paradigm, there …

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Study on the killing effect of natural killer cells combined with ATF-Fc recombinant protein on uPAR high-expressing cell lines

Tianci Tang, Xueshuai Ye, Yang Li, Guan Liu et autres

Abstract Aging and cancer are interconnected, with studies suggesting that the aging-related secretory phenotype can induce transformation between epithelial and stromal cells, as well as tumor angiogenesis. This connection suggests the feasibility of a treatment strategy that simultaneously targets tumor cells and …

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The therapeutic effect and mechanism of CXCL9-overexpressed umbilical cord mesenchymal stem cells on liver fibrosis

Yang Li, Xueqian Zhang, Guiyu Liu, Junye Wen et autres

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Rapid generation of CD19 CAR-T cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia

Xueshuai Ye, Yongqiang Wu, Hai-Qiang Zhang, Long Shi et autres

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Rapid generation of CD19 CAR-T Cells by minicircle DNA enables anti-tumor activity and prevents fatal CAR-B leukemia

Xueshuai Ye, Yongqiang Wu, Ziqi Cai, Qichen Yuan et autres

Abstract Manufacturing CAR (chimeric antigen receptor)-T cell with viral vector is expensive and time-consuming. Besides, during viral transduction, the genes encoding CARs are randomly integrated into the genome, which could cause oncogenesis or produce devastating CAR-tumor cells. Here, using virus-free and non-transgenic …

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Nonviral mcDNA-mediated bispecific CAR T cells kill tumor cells in an experimental mouse model of hepatocellular carcinoma

Hezhi Wang, Xiaoxiao Wang, Xueshuai Ye, Yi Ju et autres

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the adoptive immunotherapy of which is worth studying. CD133, a kind of cancer stem cell (CSC) antigen, together with glypican-3 (GPC3) has been proved to be highly expressed in …

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Anti-HER2 scFv-CCL19-IL7 recombinant protein inhibited gastric tumor growth in vivo

Hai-Qiang Zhang, Xueshuai Ye, Junye Wen, Ziqi Cai et autres

HER-2 targeted therapies, such as monoclonal antibodies (mAbs) and CAR-T cell therapy have been applied in the treatment of various of cancers. However, the anti-HER2 CAR-T cell therapy are limited by its expensive production procedure and fatal side effects such as cytokine …

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