Hak Sun Yu

Acanthamoeba profilin as a novel airway allergen with diverse sensitization patterns including pollen cross-reactivity

Mi Kyung Park, Hye‐Kyung Park, Hak Sun Yu

Profilins are ubiquitous pan-allergens responsible for cross-reactivity between pollens and plant foods. While we previously demonstrated that recombinant Acanthamoeba profilin (rAc-PF) drives allergic airway inflammation via Th2/Th17 pathways in murine models, its clinical relevance in human allergic disease remains unclear. This study …

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Prevalence and serovar distribution of Salmonella isolated from commercial layer farms in Korea

Soo Kyung Park, Jae Kyung Lee, Hak Sun Yu, Young Ju Lee

Microarray-based characterization of airway inflammation induced by environmental Acanthamoeba exposure versus the ovalbumin-alum model

Shin Ae Kang, Hak Sun Yu

The ovalbumin (OVA)-alum mouse model, which induces a Th2-biased immune response, is commonly used to study allergic airway inflammation. However, the artificial nature of this model limits its relevance to environmental or infection-related airway diseases. The free-living environmental protozoan Acanthamoeba is a …

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Strain-dependent immune responses reveal a critical role of IL-17A in defense against Balamuthia mandrillaris

Yu Jin Jeong, Mi Kyung Park, Seo Yeong Choi, Shin Ae Kang et autres

Balamuthia mandrillaris is a causative agent of granulomatous amebic encephalitis, a rare but often fatal condition. To investigate the role of T helper (Th) cell subsets in the immune response against B. mandrillaris, we examined 3 mouse strains with distinct immunological profiles: …

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Aux/IAAs: specificity and redundancy

Qiming Wen, Qian Gong, Hak Sun Yu, Panyu Yang

Auxin/Indole-3-Acetic Acids(Aux/IAAs), a class of early auxin-responsive genes, encode short-lived nuclear proteins that play pivotal roles in auxin signaling. In vascular plants, Aux/IAA genes form large families-such as the 29 members in Arabidopsis, exhibiting both functional redundancy and specificity. Canonical Aux/IAA proteins …

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Therapeutic potentials of Trichinella spiralis in immune disorders: From allergy to autoimmunity

Minkyoung Cho, Hak Sun Yu

The incidence of immune system diseases is increasing globally, particularly in developed countries. The hygiene and old friend hypotheses suggest that the decreased incidence of helminth infections in these countries may underlie the rising prevalence of autoimmune, allergic, and inflammatory diseases. The …

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Paraoxonase-1 Is a Pivotal Regulator Responsible for Suppressing Allergic Airway Inflammation Through Adipose Stem Cell-Derived Extracellular Vesicles

Jae Hoon Jung, Shin Ae Kang, Ji-Hwan Park, Sung‐Dong Kim et autres

Although adipose stem cell (ASC)-derived extracellular vesicles (EVs) are as effective as ASCs in the suppression of Th2 cell-mediated eosinophilic inflammation, the role of identified pulmonary genes has not been well documented. Thus, we assessed the immunomodulatory effects of paraoxonase-1 (PON1) on …

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Immunomodulatory Effect of Adipose Stem Cell-Derived Extra-Cellular Vesicles on Cytokine Expression and Regulatory T Cells in Patients with Asthma

Jae Hoon Jung, Shin Ae Kang, Ji-Hwan Park, Sung‐Dong Kim et autres

Although mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are as effective as MSCs in the suppression of allergic airway inflammation, few studies have evaluated the immunomodulatory capacity of MSC-derived EVs in patients with asthma. Thus, we assessed the effects of adipose stem …

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Proteome identification of common immunological proteins of two nematode parasites

Shin Ae Kang, Hak Sun Yu

Although helminth parasites have different life cycles, their hosts share similar immune responses involving Th2 cell-type. Here, we extracted proteins from the larvae of Anisakis simplex complex and Trichinella spiralis to identify common and specific antigens (or allergens) associated with the Th2 …

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SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion

Sung‐Dong Kim, Shin Ae Kang, Sue Jean Mun, Hak Sun Yu et autres

The nanosized vesicles secreted from various cell types into the surrounding extracellular space are called extracellular vesicles (EVs). Although mesenchymal stem cell-derived EVs are known to have immunomodulatory effects in asthmatic mice, the role of identified pulmonary genes in the suppression of …

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Anti-Pseudomonal Effect of Nephrite-Impregnated Contact Lenses

Sangyoon Kim, Eun Jung Kim, Eun Jung Choi, Jin Woo Oh et autres

Purpose This study compared the anti-pseudomonal effects between nephrite-impregnated contact lenses (CLs) and conventional and cosmetic CLs.Methods After inoculation with Pseudomonas aeruginosa (P.aeruginosa), we counted the number of bacteria on the CL surface and observed each surface using atomic force microscopy (AFM) …

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Presence and diversity of free-living amoebae and their potential application as water quality indicators

A Reum Choi, Ji Won Seong, Jeong Hyun Kim, Jun Young Lee et autres

Free-living amoebae (FLA) are found in diverse environments, such as soils, rivers, and seas. Hence, they can be used as bioindicators to assess the water quality based solely on their presence. In this study, we determined the presence of FLA in river …

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