Linus Schömig

Krebsprävention neu denken – Impulse aus der Cancer Prevention Graduate School der Deutschen Krebshilfe

Alexia Arnold, Peter Albers, Bibiana C. Barrera Bernal, Laura Bieniosek et autres

Zusammenfassung Schätzungsweise 40–50 % aller Krebsfälle könnten verhindert oder früher erkannt werden, doch die Präventionsforschung in Deutschland steht noch am Anfang. Die 2022 von der Deutschen Krebshilfe ins Leben gerufene Cancer Prevention Graduate School (CPGS) ist das erste strukturierte Programm zur Ausbildung …

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Abstract 6794: The mouse cancer cell line atlas reveals core principles of tissue-specific cancer evolution

Sebastian Mueller, Niklas de Andrade Krätzig, Markus Tschurtschenthaler, Miguel G. Silva et autres

Abstract Oncogenes like KRAS display striking tissue specificity in their oncogenic potential, genetic interactions and phenotypic effects, but the underlying determinants remain largely unresolved. To address such fundamental questions, we developed the Mouse Cancer Cell line Atlas (MCCA), a broad utility resource …

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A disease model resource reveals core principles of tissue-specific cancer evolution

Sebastian Mueller, Niklas de Andrade Krätzig, Markus Tschurtschenthaler, Miguel G. Silva et autres

. Here, to address these questions, we developed the Mouse Cancer Cell line Atlas, a broad-utility resource of 590 comprehensively characterized models across a wide range of entities ( www.mcca.tum.de ). Comparative and functional studies using this platform, human cohorts and mice …

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Colibactin-producing E. coli promote carcinogenesis of gastroesophageal adenocarcinoma and simultaneously induce autophagy and differentiation

Andrea Proaño-Vasco, David Obwegs, Kerstin Bruder, Céline Ritzkowski et autres

ABSTRACT Background & Aims Gastroesophageal adenocarcinoma (GEAC) is a malignancy of the gastroesophageal junction (GEJ) and is associated with reflux of gastroduodenal contents and Barrett’s Esophagus (BE). A shift towards gram-negative bacteria in the microbiota of the GEJ additionally promotes inflammation and …

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Abstract 4705: FreezeO organoid biobank: A translational pipeline for precision oncology at the University Medical Center Freiburg

R. Klar, Georg Vladimirov, Tamara Sloboda, Patrick Metzger et autres

Abstract The FreezeO Organoid Biobank at the University Medical Center Freiburg represents an innovative resource and an integral extension of the Molecular Tumor Board (MTB) that enables patient-specific drug testing for precision oncology. The focus of this biobank is to isolate and …

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Loss of FXR or Bile Acid-dependent Inhibition Accelerate Carcinogenesis of Gastroesophageal Adenocarcinoma

Theresa Baumeister, Andrea Proaño-Vasco, Amira Metwaly, Karin Kleigrewe et autres

BACKGROUND & AIMS: The incidence of Barrett esophagus (BE) and gastroesophageal adenocarcinoma (GEAC) correlates with obesity and a diet rich in fat. Bile acids (BAs) support fat digestion and undergo microbial metabolism in the gut. The farnesoid X receptor (FXR) is an …

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Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

Theresa Baumeister, Andrea Proaño-Vasco, Amira Metwaly, Karin Kleigrewe et autres

Background: The incidence of Barrett esophagus (BE) and Gastroesophageal Adenocarcinoma (GEAC) correlates with obesity and a diet rich in fat. Bile acids (BA) support fat digestion and undergo microbial metabolization in the gut. The farnesoid X receptor (FXR) is an important modulator …

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KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

Akanksha Anand, Linus Schömig, Sebastian Lange, Li Tran et autres

Abstract Objective The incidence of gastro-esophageal adenocarcinoma (GEAC) has increased dramatically and is associated with Barrett’s Esophagus (BE). Gastric cardia progenitors are the likely origin for BE and GEAC. Here we analyze p53, Rb1 and Kras alterations in Lgr5 progenitor cells during …

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Patientenabgeleitete Tumororganoide – ein Therapiemodell für die Präzisionsonkologie

Linus Schömig, Michael Quante

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Histological evaluation of PAXgene tissue fixation in Barrett’s esophagus and esophageal adenocarcinoma diagnostics

Melissa Barroux, Julia Horstmann, Lisa Fricke, Linus Schömig et autres

Abstract The dysplasia grading of Barrett’s esophagus (BE), based on the histomorphological assessment of formalin-fixed, paraffin-embedded (FFPE) tissue, suffers from high interobserver variability leading to an unsatisfactory prediction of cancer risk. Thus, pre-analytic preservation of biological molecules, which could improve risk prediction …

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Reversal of Chemoresistance in Leukemia Cells Using Synthetic Bisbenzylisoquinoline Derivatives

Martin Müller, Susanne Gerndt, Anja Arner, Yu‐Kai Chao et autres

Abstract Introduction Chemoresistance represents a major problem for the treatment of leukemia patients, which frequently manifests in the multidrug resistance (MDR) phenotype1. The drug refractoriness to structurally related and unrelated drugs can be caused by the P-glycoprotein (P-gp), an efflux pump belonging …

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