Caleb Gon‐Shen Chen

High-Initial-Dose Accelerated Titration Regimen of Ropeginterferon alfa-2b in Younger Patients with Polycythemia Vera and Essential Thrombocythemia: A Consecutive Case Series Study

Sung‐Nan Pei, Caleb Gon‐Shen Chen, Hsiao‐Wen Kao, Huey-En Tzeng et autres

Introduction: Ropeginterferon alfa-2b is an emerging treatment for polycythemia vera, with growing interest in its application for essential thrombocythemia and early myelofibrosis due to its extended dosing intervals and favorable tolerability profile. However, real-world evidence regarding its dosing strategies and titration practices …

tw, nl (code pays fourni par la source)

Daratumumab‐Based Combinational Therapy as Second‐Line Treatment of Relapsed‐Refractory Multiple Myeloma: A Single‐Center Experience

Oscar C. Y. Yang, Yi‐Hao Chiang, Caleb Gon‐Shen Chen, Yu‐Cheng Chang et autres

BACKGROUND: Daratumumab represents the first-in-class fully humanized monoclonal antibody that targets CD38 for the treatment of relapsed/refractory multiple myeloma (RRMM). Evidence from randomized controlled trials has shown daratumumab to be efficacious in the setting of second-line combinational therapy for pretreated multiple myeloma. …

tw (code pays fourni par la source)

Analysis of mutation profiles in extranodal NK/T-cell lymphoma: clinical and prognostic correlations

Yu‐Cheng Chang, Hui‐Jen Tsai, To‐Yu Huang, Nai-Wen Su et autres

tw (code pays fourni par la source)

P1289: DECIPHERING THE CLONAL ARCHITECTURE IN SECONDARY ACUTE MYELOID LEUKEMIA AND DONOR CELL-DERIVED MYELODYSPLASTIC SYNDROME BY SINGLE-CELL MULTI-OMICS ANALYSIS

Ken‐Hong Lim, Lo‐Ho Chen, Meng‐Ta Sung, Yawen L. Chiang et autres

Topic: 22. Stem cell transplantation - Clinical Background: Myeloproliferative neoplasms (MPNs) are a group of clonal hematopoietic stem cell diseases. Disease transformation into secondary myelofibrosis and acute myeloid leukemia (AML) negatively impact the outcome of MPNs and are frequently related to the …

tw (code pays fourni par la source)

Local ablation of gastric cancer by reconstituted apolipoprotein B lipoparticles carrying epigenetic drugs

Chia-Lung Yang, Ying‐Jui Chao, Hao‐Chen Wang, Ya-Chin Hou et autres

Epigenetic inhibitors have shown anticancer effects. Combination chemotherapy with epigenetic inhibitors has shown high effectiveness in gastric cancer clinical trials, but severe side effect and local progression are the causes of treatment failure. Therefore, we sought to develop an acidity-sensitive drug delivery …

tw (code pays fourni par la source)

Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing

Ken‐Hong Lim, Jo-Ning Wu, To‐Yu Huang, Jie‐Yang Jhuang et autres

][6] KIT D816V mutation can be detected in .90% of SM patients. 7Interestingly, multilineage involvement of KIT D816V and multimutations in other genes such as SRSF2, ASXL1, and RUNX1 are frequently detected in advSM. 8[12] Recently, the multikinase inhibitor midostaurin was approved …

tw, us (code pays fourni par la source)

BAFF-driven NLRP3 inflammasome activation in B cells

Ken‐Hong Lim, Lih‐Chyang Chen, Kate Hsu, Chia‐Ching Chang et autres

BAFF supports B-cell survival and homeostasis by activating the NF-κB pathway. While NF-κB is also involved in the priming signal of NLRP3 inflammasome, the role of BAFF in NLRP3 inflammasome regulation is unknown. Here we report BAFF engagement to BAFF receptor elicited …

tw (code pays fourni par la source)

Acquired Resistance to JAK Inhibitors in Calr-Mutated Myeloproliferative Neoplasms

Ken‐Hong Lim, Yu‐Cheng Chang, Yi‐Hao Chiang, Huan‐Chau Lin et autres

Background: Calreticulin (CALR) mutations are one of the major driver mutations in BCL-ABL1-negative myeloproliferative neoplasm (MPN) and are frequently detected in JAK2/MPL-unmutated essential thrombocythemia and primary myelofibrosis. Mutant CALR activates JAK-STAT signaling through an MPL-dependent mechanism to mediate pathogenic thrombopoiesis in MPNs. …

tw (code pays fourni par la source)

The Impact of the Epigenetic Cancer Drug Azacitidine on Host Immunity: The Role of Myelosuppression, Iron Overload and tp53 Mutations in a Zebrafish Model

Shu-Ching Wang, Ching‐Tse Wu, Dongyu Wu, Caleb Gon‐Shen Chen et autres

The unsatisfactory real-world efficacy of the hypomethylating agent azacitidine in treating myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) has prompted us to investigate the hematological adverse events and host variables that may compromise the use of this epigenetic drug. Using the …

tw (code pays fourni par la source)

NKG2A Down-Regulation by Dasatinib Enhances Natural Killer Cytotoxicity and Accelerates Effective Treatment Responses in Patients With Chronic Myeloid Leukemia

Ming‐Chin Chang, Hung-I Cheng, Kate Hsu, Yen-Ning Hsu et autres

Chronic myeloid leukemia (CML) is a hematological malignancy characterized by the presence of t(9;22) chromosomal translocation that results in BCR-ABL fusion gene. ABL tyrosine kinase inhibitors (TKIs), such as imatinib, nilotinib, and dasatinib, are currently the front-line treatment options for CML. Recently, …

tw (code pays fourni par la source)

Distinct Microrna Profiles in Patients with Essential Thrombocythemia: Clinical and Prognostic Correlation

Yi‐Hao Chiang, Yu‐Cheng Chang, Huan‐Chau Lin, Ling Huang et autres

Abstract Background: Essential thrombocythemia (ET) is a BCL-ABL1-negative myeloproliferative neoplasm characterized by increased number of mature megakaryocytes in the bone marrow and sustained thrombocytosis in the peripheral blood. ET is associated with an increased risk of hemorrhagic and thrombotic complications and leukemic …

tw (code pays fourni par la source)

STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening

Chun‐Chia Cheng, Po-Nien Liao, Ai-Sheng Ho, Ken‐Hong Lim et autres

BACKGROUND: Cancer stem cells are capable of undergoing cell division after surviving cancer therapies, leading to tumor progression and recurrence. Inhibitory agents against cancer stem cells may be therapeutically used for efficiently eradicating tumors. Therefore, the aim of this study was to …

tw (code pays fourni par la source)