Sheila L. Arvikar

Reprint of: Lyme arthritis: It’s never too late for joint decision making

Daniel R. Stevenson, Abeer Ghuman, †̃ÅŒiwi Parker Jones, Michael Marks et autres

A 25-year-old male presented with acute swelling of the left knee consistent with an inflammatory arthritis. He was initially treated with multiple joint aspirations and intra-articular steroid injections followed by disease modifying anti-rheumatic drugs. The patient continued to have escalating flares of …

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Case 3-2026: A 58-Year-Old Woman with Diplopia and Fever

Sheila L. Arvikar, Pamela W. Schaefer, Jacob E. Lemieux, Allen C. Steere

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Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis

Morgan A. Williams, Sergio A. Hernández, Sheila L. Arvikar, Katherine B. Sulka et autres

Introduction Clinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi , which was associated with excessive inflammation and severe disease. …

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Lyme arthritis: It’s never too late for joint decision making

Daniel R. Stevenson, Abeer Ghuman, Alexis Jones, Michael Marks et autres

A 25-year-old male presented with acute swelling of the left knee consistent with an inflammatory arthritis. He was initially treated with multiple joint aspirations and intra-articular steroid injections followed by disease modifying anti-rheumatic drugs. The patient continued to have escalating flares of …

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Variants in the Late Cornified Envelope Gene Locus Are Associated With Elevated T-helper 17 Responses in Patients With Postinfectious Lyme Arthritis

Dylan Ehrbar, Sheila L. Arvikar, Katherine B. Sulka, Geena Chiumento et autres

BACKGROUND: Postinfectious Lyme arthritis (LA) is associated with dysregulated immunity and autoreactive T- and B-cell responses in joints. Here we explored the role of host genetic variation in this outcome. METHODS: The frequency of 253 702 single-nucleotide polymorphisms (SNPs) was determined in …

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Autoimmunity to synovial extracellular matrix proteins in patients with postinfectious Lyme arthritis

Korawit Kanjana, Klemen Strle, Robert B. Lochhead, Annalisa Pianta et autres

BACKGROUNDAutoimmune diseases often have strong genetic associations with specific HLA-DR alleles. The synovial lesion in chronic inflammatory forms of arthritis shows marked upregulation of HLA-DR molecules, including in postinfectious Lyme arthritis (LA). However, the identity of HLA-DR-presented peptides, and therefore the reasons …

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Lyme

Sheila L. Arvikar, John Halperin, Allen C. Steere

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Cell‐Mediated Cytotoxicity in Lyme Arthritis

David Ordóñez, Robert B. Lochhead, Klemen Strle, Annalisa Pianta et autres

Objective Obliterative microvascular lesions are found in the synovial tissue of ~50% of patients with post‐antibiotic Lyme arthritis (LA) and correlate with autoantibodies to certain vascular antigens. In this study, we identified lymphocytes with cytotoxic potential that may also mediate this feature …

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Lyme Arthritis

Sheila L. Arvikar, Allen C. Steere

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Association between anti-P. gingivalis antibodies and anti-citrullinated vimentin antibodies in the patients with rheumatoid arthritis.

Satoru Shindo, Shin Nakamura, Mohamad Rawas-Qalaji, Jan Potempa et autres

Abstract Objectives Anti-citrullinated-protein auto-antibodies (ACPA), especially that react to citrullinated vimentin (CV), are implicated in the pathogenesis of Rheumatoid arthritis (RA). P. gingivalis (Pg), a key pathogen of periodontitis, can citrullinate the host proteins by production of Pg-derived peptidylarginine deiminase (PPAD). This …

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Lyme arthritis: linking infection, inflammation and autoimmunity

Robert B. Lochhead, Klemen Strle, Sheila L. Arvikar, Janis J. Weis et autres

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Identification of Novel, Immunogenic HLA–DR‐Presented Prevotella copri Peptides in Patients With Rheumatoid Arthritis

Annalisa Pianta, Geena Chiumento, Kristina Ramsden, Qi Wang et autres

OBJECTIVE: We previously identified HLA-DR-presented epitopes from a 27-kd protein of Prevotella copri (Pc) obtained from peripheral blood mononuclear cells (PBMCs) from 1 rheumatoid arthritis (RA) patient. Herein, we sought to identify other HLA-DR-presented Pc peptides and source proteins in PBMCs from …

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