Daniel Elieh Ali Komi

Interactions Between Tryptase-Positive Mast Cells and Melanin-A+ Cells in the Microenvironment of Cutaneous Melanoma

Dmitri Atiakshin, Grigory Demyashkin, Kirill Silakov, Aleksandra Prikhodko et autres

Cutaneous melanoma remains one of the most aggressive tumors, yet the role innate immunity plays in its progression remains poorly understood. Effector elements with high regulatory potential, capable of both promoting and inhibiting tumor growth—mast cells (MCs), are of particular interest. This …

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Subtypes of Atypical Cold Urticaria and Recommendations for Their Diagnostic Workup

Dalia Melina Ahsan, Daniel Elieh Ali Komi, SARA SÜRMELİ, Mojca Bizjak et autres

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Biomarkers in Chronic Spontaneous Urticaria: Are We Ready for its Use in Clinical Practice?

Yi‐Kui Xiang, Man Hu, Daniel Elieh Ali Komi, Andaç Salman et autres

Abstract Purpose of Review This review aims to evaluate the utility of biomarkers in the diagnosis, endotyping, and management of chronic spontaneous urticaria (CSU). It seeks to address whether biomarkers are ready for integration into routine clinical practice and how they can …

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The Impact of Mast Cells on the Anatomy, Cellular Communication, and Molecular Immune Network of Lymph Nodes

Daniel Elieh Ali Komi, Marcus Maurer, Frank Siebenhaar

Lymph nodes (LNs) are ovoid-shape capsulated structures interposed along the lymphatic vessels. Owing to their unique architecture, LNs place immune cell types in distinct compartments allowing effective contact of antigens to them. Their efficient function results in the concentration of antigens and …

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Immunomodulatory Significance of Mast Cell Exosomes (MC-EXOs) in Immune Response Coordination

Daniel Elieh Ali Komi, Farzaneh Shafaghat, Shamila D. Alipoor, Tohid Kazemi et autres

Mast cells (MCs) communicate with other cells by direct cell-to-cell interaction, secreting mediators, and releasing exosomes (EXOs). MC-exosomes (MC-EXOs) contain proteins, lipids, mRNAs, and noncoding RNAs (ncRNAs), exhibit typical EXO markers such as heat shock proteins, tetraspanins, tumor susceptibility gene 101 protein …

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Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists

Sima Heidarzadeh-Asl, Marcus Maurer, Amir Kiani, Dmitri Atiakshin et autres

, molecular weight 111.15 g/mol) is a well-studied endogenous biogenic amine composed of an imidazole ring attached to an ethylamine side chain. It has a limited half-life of a few minutes within tissues and in circulation. Several cell types including mast cells …

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Mitigating effects of agmatine on myocardial infarction in rats subjected to isoproterenol

Daniel Elieh Ali Komi, Fatemeh Yarmohammadi, Maryam Nezamabadi, Mohammad Reza Khirehgesh et autres

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Psychological Stress and Urticaria: Pathophysiologic and Therapeutic Updates

Yi‐Kui Xiang, Murat Türk, Iván Chérrez-Ojeda, Daniel Elieh Ali Komi et autres

Abstract Purpose of review The goal of this review is to examine the relationship between psychological stress and chronic urticaria (CU), focusing on the underlying mechanisms and potential therapeutic interventions. The paper seeks to answer how stress exacerbates CU and the neuro-immunological …

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Renal Mast Cell-Specific Proteases in the Pathogenesis of Tubulointerstitial Fibrosis

Dmitri Atiakshin, С. Л. Морозов, В. В. Длин, A. A. Kostin et autres

Chronic kidney disease is detected in 8-15% of the world's population. Along with fibrotic changes, it can lead to a complete loss of organ function. Therefore, a better understanding of the onset of the pathological process is required. To address this issue, …

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The Contribution of Mast Cells to the Regulation of Elastic Fiber Tensometry in the Skin Dermis of Children with Marfan Syndrome

Dmitri Atiakshin, Е. А. Николаева, А. N. Semyachkina, A. A. Kostin et autres

Marfan syndrome (MFS) is a hereditary condition accompanied by disorders in the structural and regulatory properties of connective tissue, including elastic fibers, due to a mutation in the gene encodes for fibrillin-1 protein (FBN1 gene) and the synthesis of abnormal fibrillin-1 glycoprotein. …

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Linoleic Acid Modulates the Expression of Metastatic and Angiogenic Markers MMP-2 and Talin-2 in Gastric Cancer Cell Line MKN-45

Daniel Elieh Ali Komi, Tohid Kazemi, Najibeh Shekari, Parviz Farzamifar et autres

Background: Linoleic acid (LA) has modulatory effects on gastric cancer cell lines. This study aimed to investigate the effects of linoleic acid on the expression of metastatic and angiogenic molecular markers in gastric cancer cell line MKN-45. Methods: In this study performed …

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Skin mast cells in Marfan syndrome: specific emphasis on connective tissue remodeling

Dmitri Atiakshin, Е. А. Николаева, D. Yu. Gritsevskaya, А. N. Semyachkina et autres

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