Juan Alfonso Redondo

Heritable single-cell gene expression states shape functional variability in innate immune responses

Juan Alfonso Redondo, Nguyen Truong Co, Nissrin Alachkar, Josephine C. Moran et autres

Abstract Activation of innate immunity at the single-cell level is inherently heterogeneous, yet the mechanisms underlying this variability remain incompletely understood. Here, we integrate transcriptomics, high-content imaging and mathematical modelling to quantify transcriptional heritability within the evolutionarily conserved Toll-like receptor (TLR) system. …

pl, de, gb, us (code pays fourni par la source)

Heterogeneity of bacterial host-pathogen interactions across biological scales

Juan Alfonso Redondo, Niharika Purkait, Pawel Paszek

ABSTRACT Recent advances in single-cell technologies have revealed the dynamic and heterogeneous nature of host-pathogen interactions at the single-cell level. This review explores how cellular variability—both within clonal bacterial populations and among genetically identical host cells—gives rise to distinct infection outcomes, from …

pl, gb, ca (code pays fourni par la source)

Single-cell gene expression patterns of the Toll-like receptor signalling are heritable traits

Juan Alfonso Redondo, Nguyen Truong Co, Pawel Paszek

pl (code pays fourni par la source)

PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy

Juan Alfonso Redondo, Romain Bibes, Alizée Vercauteren Drubbel, Benjamin Dassy et autres

Esophageal squamous cell carcinoma (eSCC) accounts for more than 85% cases of esophageal cancer worldwide and the 5-year survival rate associated with metastatic eSCC is poor. This low survival rate is the consequence of a complex mechanism of resistance to therapy and …

be (code pays fourni par la source)

Overlapping but distinct: a new model for G-quadruplex biochemical specificity

Martin Volek, Sofia Kolesnikova, Kateřina Švehlová, Pavel Srb et autres

G-quadruplexes are noncanonical nucleic acid structures formed by stacked guanine tetrads. They are capable of a range of functions and thought to play widespread biological roles. This diversity raises an important question: what determines the biochemical specificity of G-quadruplex structures? The answer …

cz (code pays fourni par la source)

Hydroxyl versus permethylated glycopolymers as gene carriers

Juan Alfonso Redondo, Enrique Martínez‐Campos, Rodrigo Navarro, Mónica Pérez-Perrino et autres

es (code pays fourni par la source)

Cell Adhesion and Proliferation on Sulfonated and Non-Modified Chitosan Films

Enrique Martínez‐Campos, Ana Civantos, Juan Alfonso Redondo, Rodrigo Guzmán et autres

es (code pays fourni par la source)

Polymeric Gene Carriers Bearing Pendant β-Cyclodextrin: The Relevance of Glycoside Permethylation on the “In Vitro” Cell Response

Juan Alfonso Redondo, Enrique Martínez‐Campos, Laetitia Plet, Mónica Pérez-Perrino et autres

The incorporation of cyclodextrins (CDs) to nonviral cationic polymer vectors is very attractive due to recent studies that report a clear improvement of their cytocompatibility and transfection efficiency. However, a systematic study on the influence of the CD derivatization is still lacking. …

es, fr, ie (code pays fourni par la source)

Effect on in vitro cell response of the statistical insertion of N-(2-hydroxypropyl) methacrylamide on linear pro-dendronic polyamine’s gene carriers

Juan Alfonso Redondo, Enrique Martínez‐Campos, Rodrigo Navarro, Helmut Reinecke et autres

es (code pays fourni par la source)

Potential of prodendronic polyamines with modulated segmental charge density as novel coating for fast and efficient analysis of peptides and basic proteins by CE and CE‐MS

Tanize Acunha, Clara Ibáñez, María Isabel Pascual Reguera, Mariagiovanna Sarò et autres

In this work, the suitability of a new polymer family has been investigated as capillary coatings for the analysis of peptides and basic proteins by CE. This polymer family has been designed to minimize or completely prevent protein-capillary wall interactions and to …

br, es, it (code pays fourni par la source)

Synergistic effect of pendant hydroxypropyl and pyrrolidine moieties randomly distributed along polymethacrylamide backbones on in vitro DNA-transfection

Juan Alfonso Redondo, Diego Velasco, Mónica Pérez-Perrino, Helmut Reinecke et autres

es, ie (code pays fourni par la source)

Prodendronic polyamines from stable or labile methacrylates obtained by selective Michael addition onto asymmetric diacrylic compounds

Juan Alfonso Redondo, Rodrigo Navarro, Enrique Martínez‐Campos, Mónica Pérez-Perrino et autres

A new synthetic strategy for the preparation of methacrylic monomers and polymers carrying acyl β-amino groups is presented. The approach is based on the Michael addition of aliphatic amines onto asymmetric acrylic/methacrylic compounds, reacting the amine highly selectively with the acrylic unit …

es (code pays fourni par la source)