Jiaxian Wang

Development and validation of a prediction model for long-term cognitive frailty risk in stroke patients based on CHARLS data

Shunli Zuo, Ning Liu, Jiaxian Wang, Jingling Li et autres

BACKGROUND: This study aimed to develop and validate machine learning (ML) models for predicting the risk of cognitive frailty in community-dwelling elderly adults with stroke. METHODS: This study involved 2,325 stroke survivors from the China Health and Retirement Longitudinal Study (CHARLS), conducted …

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Gastric signet‐ring cell carcinoma in a child: A clinical case study

Jiaxian Wang, Yang Yang, Jiangnan Wei, Jiayin Chen et autres

Gastric signet-ring cell carcinoma (SRCC) is a rare form of gastric cancer characterized by mucus-rich tumor cells forming a distinctive ring-like appearance and is exceedingly rare in children, accounting for less than 1% of all childhood malignancies. We report a case of …

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Latent profile analysis and influencing factors for cluster of psychosomatic symptoms among chinese middle-aged and older ischemic stroke survivors

Jiayin Chen, Jiaxian Wang, Jiangnan Wei, Kezhou Yang et autres

BACKGROUND: A deeper understanding of individual differences in symptom experiences among middle-aged and older ischemic stroke survivors could enable healthcare professionals to identify previously unknown associations among complex symptoms. This study employs latent class analysis to characterize psychosocial symptom clusters in this …

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Development and validation of a risk identification model for frailty in stroke survivors: new evidence from CHARLS

Jiaxian Wang, Rick Yiu Cho Kwan, Lorna Kwai Ping Suen, Simon Ching Lam et autres

BACKGROUND: Stroke survivors with frailty exhibit elevated rates of complications, mortality, disability, and hospital readmission. As frailty represents an early, reversible, and preventable stage of disability, developing a reliable risk identification model is essential. This study aimed to develop and validate a …

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The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies

Xiuyuan Zhu, Jiangnan Wei, Jingling Li, Jiaxian Wang et autres

BACKGROUND: Homocysteine (Hcy) has been implicated in the development of multiple diseases; however, its causal role remains unclear. Mendelian randomization (MR) studies provide a robust approach to assessing causality by minimizing confounding and reverse causation. OBJECTIVE: This study aimed to evaluate the …

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Development and validation of a risk prediction model for frailty in older nappers

Lijing Chen, Jiaxian Wang, Ning Liu, Li Geng et autres

Frailty among older adults has received widespread attention from society, especially among nappers. The objective of this study was to develop a frailty prediction model for nappers. The data source was the China Health and Retirement Longitudinal Study, with a cohort of …

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Mendelian randomization studies in ankylosing spondylitis: A systematic review

Jiangnan Wei, Xiuyuan Zhu, Jiaxian Wang, Kezhou Yang et autres

INTRODUCTION: Previous research has revealed connections between ankylosing spondylitis (AS) and comorbid conditions. However, observational studies frequently encounter difficulties in establishing definitive causal links between potential risk factors and AS. In contrast, Mendelian randomization (MR) offers a more robust approach to exploring …

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Stroke and frailty index: a two-sample Mendelian randomisation study

Jiangnan Wei, Jiaxian Wang, Jiayin Chen, Kezhou Yang et autres

INTRODUCTION: Previous observational studies have found an increased risk of frailty in patients with stroke. However, evidence of a causal relationship between stroke and frailty is scarce. The aim of this study was to investigate the potential causal relationship between stroke and …

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Development and validation of a risk prediction model for physical frailty in older adults who are disabled

Lijing Chen, Jiaxian Wang, Li Geng, Yi Li

Physical frailty is highly prevalent among the older adults who are disabled. The aim of this study was to explore the risk factors for physical frailty in older adults who are disabled and construct a nomogram prediction model. The data source was …

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Lists of geriatric syndromes in the Asian-Pacific geriatric societies

Chang Won Won, Hyung Joon Yoo, Shun-Hsuan Yu, Chang Oh Kim et autres

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GFAP mutations, age at onset, and clinical subtypes in Alexander disease

Morgan J. Prust, Jiaxian Wang, Hiroki Morizono, Albee Messing et autres

OBJECTIVE: To characterize Alexander disease (AxD) phenotypes and determine correlations with age at onset (AAO) and genetic mutation. AxD is an astrogliopathy usually characterized on MRI by leukodystrophy and caused by glial fibrillary acidic protein (GFAP) mutations. METHODS: We present 30 new …

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The Effects of Resident and Nursing Home Characteristics on Activities of Daily Living

Jiaxian Wang, Robert L Kane, Lynn E. Eberly, Beth A Virnig et autres

BACKGROUND: Existing studies on the relationships between impairments and activities of daily living (ADLs) in nursing home residents have serious limitations. This study examines the relationships among admission impairments, including pain, depression, incontinence, balance, and falls, and follow-up ADLs, as well as …

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