Amit Fischer

Metamaterial-based injection molding for the cost-effective production of whole cuts

Mohammad Ghosheh, Avner Ehrlich, Amit Fischer, Laura Pasitka et autres

The escalating global demand for meat products has intensified ecological concerns, underscoring the need for sustainable meat alternatives. Although current methods effectively imitate ground meat, mimicking whole cuts, which constitute 54% of the global market, remains challenging due to the lack of …

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Stimuli‐Responsive Hydrogel Microcapsules Harnessing the COVID‐19 Immune Response for Cancer Therapeutics

Amit Fischer, Avner Ehrlich, Yevgeni Plotkin, Yu Ouyang et autres

The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against …

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Stimuli‐Responsive Hydrogel Microcapsules Harnessing the COVID‐19 Immune Response for Cancer Therapeutics

Amit Fischer, Avner Ehrlich, Yevgeni Plotkin, Yu Ouyang et autres

Abstract The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli‐responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response …

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Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids

Mohammad Ghosheh, Avner Ehrlich, Konstantinos Ioannidis, Muneef Ayyash et autres

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DNA‐Tetrahedra Corona‐Modified Hydrogel Microcapsules: “Smart” ATP‐ or microRNA‐Responsive Drug Carriers

Amit Fischer, Pu Zhang, Yu Ouyang, Yang Sung Sohn et autres

The assembly of adenosine triphosphate (ATP)-responsive and miRNA-responsive DNA tetrahedra-functionalized carboxymethyl cellulose hydrogel microcapsules is presented. The microcapsules are loaded with the doxorubicin-dextran drug or with CdSe/ZnS quantum dots as a drug model. Selective unlocking of the respective microcapsules and the release …

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Biocatalytic cascades and intercommunicated biocatalytic cascades in microcapsule systems

Pu Zhang, Amit Fischer, Yu Ouyang, Jianbang Wang et autres

DNAzyme cascade. The guided separation and formation of dynamic supramolecular dimer microcapsular containments, and the dictated switchable operation of intercommunicated biocatalytic cascades are demonstrated.

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Topologically switchable and gated transcription machinery

Pu Zhang, Amit Fischer, Yu Ouyang, Yang Sung Sohn et autres

-ion/KP topologically triggered DNA tetrahedra promoter-transcription scaffold, for the replication of the MG RNA aptamer, and T7 RNA polymerase are integrated into DNA-based carboxymethyl cellulose hydrogel microcapsules acting as cell-like assemblies. The switchable, reversible transcription of the MG RNA aptamer in a …

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Aminoglycoside-induced lipotoxicity and its reversal in kidney on chip

Konstantinos Ioannidis, Aarón Cohen, Mohammad Ghosheh, Avner Ehrlich et autres

, leading to a 3.2-fold increase in glucose uptake, and reverse TCA cycle flux culminating in a 40-fold increase in lipid accumulation. Blocking glucose reabsorption using the SGLT2 inhibitor empagliflozin significantly reduced gentamicin toxicity by 10-fold. These results demonstrate the utility of …

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Aptamer-modified DNA tetrahedra-gated metal–organic framework nanoparticle carriers for enhanced chemotherapy or photodynamic therapy

Pu Zhang, Amit Fischer, Yu Ouyang, Jianbang Wang et autres

UiO-66 metal-organic framework nanoparticles (NMOFs) gated by aptamer-functionalized DNA tetrahedra provide superior biomarker-responsive hybrid nano-carriers for biomedical applications. Hybrid nano-carriers consisting of ATP-aptamer or VEGF-aptamer functionalized tetrahedra-gated NMOFs are loaded with the chemotherapeutic drug, doxorubicin (DOX). In the presence of ATP or …

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Constitutional Dynamic Networks-Guided Synthesis of Programmed “Genes”, Transcription of mRNAs, and Translation of Proteins

Sivan Lilienthal, Guo‐Feng Luo, Shan Wang, Liang Yue et autres

Inspired by nature, where dynamic networks control the levels of gene expression and the activities of transcribed/translated proteins, we introduce nucleic acid-based constitutional dynamic networks (CDNs) as functional modules mimicking native circuits by demonstrating CDNs-guided programmed synthesis of genes, controlled transcription of …

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Single and Bilayer Polyacrylamide Hydrogel-Based Microcapsules for the Triggered Release of Loads, Logic Gate Operations, and Intercommunication between Microcapsules

Sivan Lilienthal, Amit Fischer, Wei‐Ching Liao, Rémi Cazelles et autres

A method to assemble loaded stimuli-responsive DNA-polyacrylamide hydrogel-stabilized microcapsules is presented. The method involves coating substrate-loaded CaCO 3 microparticles, functionalized with nucleic acid promoter units, and cross-linking DNA-modified polyacrylamide chains on the microcapsules, using the hybridization chain reaction (HCR) to yield the …

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Triggered Release of Loads from Microcapsule-in-Microcapsule Hydrogel Microcarriers: En-Route to an “Artificial Pancreas”

Amit Fischer, Sivan Lilienthal, Margarita Vázquez‐González, Michael Fadeev et autres

Abstract A method to assemble stimuli-responsive nucleic acid-based hydrogel-stabilized microcapsule-in-microcapsule systems is introduced. An inner aqueous compartment stabilized by a stimuli-responsive hydrogel-layer (∼150 nm) provides the inner microcapsule (diameter ∼2.5 μm). The inner microcapsule is separated from an outer aqueous compartment stabilized …

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