Sandrine Degryse

Tu2044: QUANTITATIVE HISTOLOGIC FEATURES OF THE INFLAMMATORY MICROENVIRONMENT USING DIGITAL PATHOLOGY PRIOR TO ADALIMUMAB TREATMENT ALLOWS PREDICTION OF RESPONSE IN PATIENTS WITH ULCERATIVE COLITIS.

John Shamshoian, Fedaa Najdawi, Sandrine Degryse, Christina Jayson et autres

Abstract 2425: AI-powered approaches accurately predict t(11;14) positive multiple myeloma from H&E-stained histologic sections by identifying regions demonstrating lymphoplasmacytic cytology

Neel H Patel, Raymond Biju, Syed Ashar Javed, Sandrine Degryse et autres

Abstract Venetoclax, a highly selective oral BCL-2 inhibitor, has demonstrated efficacy in patients with t(11;14) multiple myeloma (MM). Fluorescence in situ hybridization (FISH) is the mainstay methodology to determine t(11;14) status, but requires significant quantities of bone marrow tissue or aspirate and …

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DOP062 Quantitative histologic features of the inflammatory microenvironment using digital pathology prior to adalimumab treatment allows prediction of response in patients with Ulcerative Colitis.

John Shamshoian, Faris Najdawi, Sandrine Degryse, Christina Jayson et autres

Abstract Background Ulcerative Colitis (UC) is a chronic, immune-mediated disease. Despite the advent of anti-inflammatory biologics, the degree of response to therapy is unpredictable and achievement of deeper responses is limited to a minority of patients, rendering the choice of therapy complex …

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Abstract 905: ML quantification of tumor-Infiltrating lymphocytes distinguishes immune-phenotypes and reveals phenotypic heterogeneity

Nhat Le, Bahar Rahsepar, Jennifer Hipp, Jake Conway et autres

Abstract Immune phenotypes (IP), defined by the tumor-infiltrating lymphocyte (TIL) distribution within the tumor microenvironment (TME), is prognostic and predictive of treatment response. Here, machine learning (ML) models that characterize the TME were deployed in non-small cell lung cancer (NSCLC) and head …

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Antibody-mediated blockade of the IL23 receptor destabilizes intratumoral regulatory T cells and enhances immunotherapy

Andrew E. Wight, Jessica Margaret Sido, Sandrine Degryse, Lin Ao et autres

Regulatory T cells (Treg) can impede antitumor immunity and currently represent a major obstacle to effective cancer immunotherapy. Targeting tumor-infiltrating regulatory Treg while sparing systemic Treg represents an optimal approach to this problem. Here, we provide evidence that the interleukin 23 receptor …

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A tumor-infiltrating IL23R-expressing CD4+ Treg population represents a safe and potent immunotherapeutic candidate in mice

Andrew E. Wight, Jessica Margaret Sido, Sandrine Degryse, Oba Oseghali et autres

Abstract Interleukin 23 receptor (IL23R) is a signaling protein normally implicated in gut T cell development, but which has also been correlated with poor cancer prognoses. Previous studies have found that interfering with this pathway results in improved cancer outcomes in mice. …

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