Anna-Sophia Baur

Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients

Verena Holzmüller, Jana Gawron, Ann‐Cathrin Burk, Anna-Verena Stell et autres

The success of allogeneic hematopoietic cell transplantation (allo-HCT) is limited by acute graft-versus-host disease (aGVHD). We have previously reported that neutrophils can exacerbate tissue damage caused by conditioning regimens. Pegtarazimod is a synthetic peptide, derived from the capsid protein of human astrovirus …

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Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study

Jonas S. Heitmann, Yacine Maringer, Susanne Jung, Marcel Wacker et autres

BACKGROUND: Therapeutic T-cell activation to induce tumour-specific immune responses promises sustainable cancer control. However, this treatment is not yet widely used because of the challenges of personalised drug design and a shortage of mutation-derived neoepitopes. This study aimed to evaluate the immunogenicity, …

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Gastrin for the treatment of acute graft-versus-host disease of the stomach

Jana Gawron, Marie Czech, Tamina Rückert, Verena Holzmüller et autres

ABSTRACT: Acute graft-versus-host disease (aGVHD) is a major cause of death after allogeneic hematopoietic cell transplantation, and patients with steroid-refractory aGVHD have a dismal prognosis. We have previously shown that the enteroendocrine hormone glucagon-like peptide-2 has tissue regenerative activity in the lower …

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Gastrin for the treatment of acute graft-versus-host disease of the stomach

Jana Gawron, Marie Czech, Grigor Andreev, Verena Holzmüller et autres

Abstract Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for many hematological malignancies. However, its success is frequently compromised by acute graft-versus-host disease (aGVHD), a severe complication driven by allogeneic T cell-mediated organ damage. While lower gastrointestinal involvement is well …

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FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia

Melissa Zwick, Bastian Zinkel, Corinna Spohr, Tamina Rückert et autres

FMS-like tyrosine kinase-3 internal tandem duplication (FLT3-ITD) mutations are frequent in acute myeloid leukemia (AML) and are associated with a high risk of relapse. CKLF-like MARVEL transmembrane domain containing member 6 (CMTM6) stabilizes PD-L1 surface expression and modulates tumor immunity in solid …

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A contribution to the question of monocyte leukemia.

Anna-Sophia Baur