Accès ouvert
2026
preprint
OpenAlex
Swetapadma Sahu, Yue Hao, Angela Baker, Kondaiah Palsa et autres
Abstract Background Glioblastoma (GBM) is a sex-biased disease characterized by higher incidence and poorer survival in males. These sex differences are primarily driven by metabolic and immune signatures, with iron metabolism playing a major role. While iron is essential for tumor cell …
us
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Accès ouvert
2026
article
OpenAlex
Ganesh Shenoy, Marina Thomas, Amol S. Jeur
ABSTRACT: Biliary cystadenoma (BC) of the liver is a rare benign cystic lesion. Recurrence following excision is uncommon, and aberrant hepatic arterial anatomy adds further surgical complexity. A 25-year-old female underwent laparotomy 3 years earlier for a presumed hydatid cyst; histopathology revealed …
in
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Accès ouvert
2026
article
OpenAlex
Swetapadma Sahu, Kondaiah Palsa, Ganesh Shenoy, Becky Slagle‐Webb et autres
PURPOSE: Glioblastoma (GBM) cells have a higher iron requirement than normal cells and therefore upregulate iron uptake. However, elevated intracellular iron levels can render cancer cells susceptible to ferroptosis, a non-apoptotic, iron-dependent form of cell death. Tumor-associated macrophages (TAMs) are the most …
us
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Accès ouvert
2025
preprint
OpenAlex
Swetapadma Sahu, Kondaiah Palsa, Ganesh Shenoy, Becky Slagle‐Webb et autres
Tumor-associated macrophages (TAMs) are the most abundant non-tumor cell type in glioblastoma (GBM) and act as the pivotal cell type in regulating iron metabolism in the GBM tumor microenvironment. High TAM infiltration into the TME is also associated with increased resistance to …
us
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Accès ouvert
2025
preprint
OpenAlex
Chachrit Khunsriraksakul, Fan Zhang, Lida Wang, Siyuan Chen et autres
Abstract Protein quantitative trait loci (pQTLs) provide insight into the genetic regulation of protein expression and disease biology. We performed a large-scale cross-platform meta-analysis of plasma proteomics, integrating data from over 90,000 individuals across Olink and SomaScan platforms. This effort identified >30,000 …
us
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2025
conference-abstract
OpenAlex
Swetapadma Sahu, Kondaiah Palsa, Ganesh Shenoy, Becky Slagle‐Webb et autres
Abstract Glioblastoma (GBM) is a highly aggressive and difficult-to-treat brain tumor originating from astrocytes. It is also sexually dimorphic, with females having a survival advantage and responding better to standard therapy. Sex-biased differences in iron metabolism play a significant role in making …
us
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Accès ouvert
2025
article
OpenAlex
Ganesh Shenoy, Swetapadma Sahu, Madison K. Kuhn, Vladimir Khristov et autres
INTRODUCTION: Little is known about the role of transition metals in glioblastoma progression. Here we investigated whether transition metal content is associated with glioblastoma outcomes. METHODS: Tumor samples were obtained from 37 newly diagnosed patients with glioblastoma, 21 of which had matched …
us
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Accès ouvert
2025
peer-review
OpenAlex
Manjunath Shetty, Smita Shenoy, Arul Amuthan, Vasudha Devi et autres
Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor clinical outcomes. Hence cost-effective drugs with fewer side effects as a standard supportive therapy might yield substantial advantages in efficacy and safety. Kadukkai maathirai (KM) is being used as a supplement in …
in, my, us
(code pays fourni par la source)
Accès ouvert
2024
conference-abstract
OpenAlex
Swetapadma Sahu, Kondaiah Palsa, Ganesh Shenoy, Becky Slagle‐Webb et autres
Abstract Glioblastoma (GBM) is an aggressive brain cancer that is extremely difficult to treat. GBM is sexually dimorphic in nature, where females are less susceptible to developing GBM, respond to therapy better, and get a survival advantage. Sex-biased differences in tumor iron …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Swetapadma Sahu, Kondaiah Palsa, Ganesh Shenoy, Timothy Helmuth et autres
Abstract Glioblastoma (GBM) is an aggressive brain cancer that is sexually dimorphic in nature, with females less susceptible to developing it, responding better to therapy, and gaining a survival advantage. Iron metabolism is also sexually dimorphic and has been shown previously to …
us
(code pays fourni par la source)
Accès ouvert
2024
peer-review
OpenAlex
Manjunath Shetty, Smita Shenoy, Arul Amuthan, V. Gayathri Devi et autres
Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor clinical outcomes. Hence cost-effective drugs with fewer side effects as a standard supportive therapy might yield substantial advantages in efficacy and safety. Kadukkai maathirai (KM) is being used as a supplement in …
in, my, us
(code pays fourni par la source)
Accès ouvert
2024
peer-review
OpenAlex
Manjunath Shetty, Smita Shenoy, Arul Amuthan, V. Gayathri Devi et autres
Background Hepatocellular carcinoma (HCC) is an aggressive malignancy with poor clinical outcomes. Hence cost-effective drugs with fewer side effects as a standard supportive therapy might yield substantial advantages in efficacy and safety. Kadukkai maathirai (KM) is being used as a supplement in …
in, my, us
(code pays fourni par la source)