Giulia Sedda

Epiproteomic profiling identifies histone H4 hyperacetylation as a prognostic marker in pleural mesothelioma

Roberta Noberini, Ioanna Bischinioti, Simone Zanetti, Alessandro Vai et autres

Pleural mesothelioma (PM) is an aggressive tumor that arises from mesothelial cells as a consequence of asbestos exposure. Despite recent therapeutic advances, the prognosis of PM remains poor, with a median overall survival typically below 18 months. Here, we investigated the association …

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Safety and Efficacy of Single-Stage Synchronous Bilateral VATS Talc Poudrage for Malignant Pleural Effusion

Antonio Mazzella, Sara Degiovanni, Elena Mariani, Giorgia Cerretani et autres

Backgrounds/Objectives: Malignant pleural effusion (MPE) is a frequent complication of advanced cancer, and talc pleurodesis via video-assisted thoracoscopic surgery (VATS) represents a standard palliative treatment with high efficacy. However, evidence regarding synchronous bilateral pleurodesis in patients with bilateral MPE is limited. This …

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Epiproteomic Profiling Identifies Histone H4 Hyperacetylation as a Prognostic Marker in Pleural Mesothelioma

Roberta Noberini, Ioanna Bischinioti, Simone Zanetti, Alessandro Vai et autres

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Recurrent Malignant Pericardial Effusion Management: The Pericardio-Peritoneal Window

Antonio Mazzella, G Caffarena, Claudia Bardoni, Giuseppe Nicolosi et autres

Introduction: Malignant pericardial effusion (MPE) represents a relatively rare complication in various types of solid tumors. Its management is often challenging. One solution can be represented by surgical approaches, including a pericardio-peritoneal window (PPW), which allows draining the fluid into the abdominal …

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A prognostic model for use before elective surgery to estimate the risk of postoperative pulmonary complications (GSU-Pulmonary Score): a development and validation study in three international cohorts

Laura Bravo, Joana F F Simoes, Victor Roth Cardoso, Adewale Adisa et autres

BACKGROUND: Pulmonary complications are the most common cause of death after surgery. This study aimed to derive and externally validate a novel prognostic model that can be used before elective surgery to estimate the risk of postoperative pulmonary complications and to support …

Integrating artificial intelligence tool in multidisciplinary tumor board for predicting complications after lung cancer surgery

Luca Bertolaccini, Elena Prisciandaro, Clarissa Uslenghi, Gabriele Maffeis et autres

Background: Artificial intelligence (AI) may support multidisciplinary NSCLC decision-making Aims: To develop AI to predict postoperative complications (POC) after lung resection for NSCLC Methods: Retrospective review of clinical records of lung resection for NSCLC in 2020-2021 Multivariate analyses defined statistically significant POC …

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Real-world survival outcomes of wedge resection versus lobectomy for cT1a/b cN0 cM0 non-small cell lung cancer: a single center retrospective analysis

Luca Bertolaccini, Andrea Cara, Matteo Chiari, Cristina Diotti et autres

Background: JCOG0802/WJOG4607L showed benefits in overall survival (OS) of segmentectomy. CALGB 140503 confirmed that sublobar resection was not inferior to lobectomy concerning recurrence-free survival (RFS) but did not provide specific OS and RFS according to the techniques of sublobar resections. Hence, we …

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Specific motor learning induced by space-variant visual feedback distortion of the hand position

Giulia Sedda, Giulia Olla, Danilo Pani

During the execution of a reaching movement, small errors in the trajectory are exploited to improve the following movements. Motor adaptation studies often investigate this error-driven learning by perturbing movements and evaluating the after-effect. A blocked design is usually adopted, where the …

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Diagnostic Performance and Cell Count of EBUS–TBNA Needle Gauges: A Prospective Trial

Juliana Guarize, Cristina Diotti, Monica Casiraghi, Stefano Donghi et autres

Background. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic procedure for evaluating hilar and mediastinal lymphadenopathies and is the gold standard for lung cancer diagnosis and staging. Recent studies assessed the effectiveness of the 19-G flex needle in obtaining larger …

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The Role of Surgery in Primary Chest Wall Tumors: Over 20 Years’ Experience in Resection and Reconstruction

Giorgio Lo Iacono, Antonio Mazzella, Shehab Mohamed, Francesco Petrella et autres

BACKGROUND: Primary chest wall tumors comprise a heterogeneous group of neoplasms arising from soft tissues and bones. While surgical excision is the standard of care for benign tumors, the management of malignant tumors requires multimodal treatment. We conducted a predictive analysis of …

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Surgically Treated pT2aN0M0 (Stage IB) Non-Small Cell Lung Cancer: A 20-Year Single-Center Retrospective Study

Monica Casiraghi, Francesco Petrella, Claudia Bardoni, Shehab Mohamed et autres

Introduction The suitability of adjuvant therapy (AT) in patients with stage IB non-small cell lung cancer (NSCLC) is still under debate considering the cost–benefit ratio between improvement in survival and side effects. We retrospectively evaluated survival and incidence of recurrence in radically …

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First responder prototype uniform and first aid for kids' device design, V2

Laura Giraldi, Giulia Sedda, Marta Maini, Francesca Morelli et autres

During the first year of the project, the smart uniform has been studied and designed. The prototype is composed of two layers: the external protective and performant uniform for first responders (FR), composed of a jacket and trousers, and then smart underwear …