Marc Daigneault

Photophysical, thermal and imaging studies on vancomycin functional branched poly( N -isopropyl acrylamide) of differing degrees of branching containing nile red for detection of Gram-positive bacteria

Thomas Swift, Richard Hoskins, Mariya Kalinichenko, Maria G. Katsikogianni et autres

). These branched systems selectively desolvate with temperature or binding interactions depending on their chain architecture. We have prepared samples with three different degrees of branching which have incorporated Nile red acrylate as a low concentration of co-monomer to report upon their …

gb (code pays fourni par la source)

RARβ Expression in Keratinocytes from Potentially Malignant Oral Lesions: The Functional Consequences of Re-Expression by De-Methylating Agents

Raghu Radhakrishnan, Hannah Crane, Marc Daigneault, Kanaka Sai Ram Padam et autres

Loss of RARβ2 expression by promoter methylation is an early event in oral carcinogenesis. Understanding the mechanisms and consequences of RARβ loss may aid in understanding the disappointing results of retinoid chemoprevention trials. This study aimed to describe the effects of all-trans …

in, gb, Afrique du Sud (code pays fourni par la source)

From Paper to Product: Engineering a 27,000 kg Fully Electric Mobile Railcar Mover in 6 Months

Marc Daigneault, Frederick Prigge, Bruno Tellier

In this paper, the authors present the challenges & opportunities behind the engineering of a fully-electric mobile railcar mover. We present how building the right toolbox of simulation software, proper analysis and understanding of the duty cycle and usage of unconventional vehicles …

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Micromorts - what is the risk?

A.M. Fry, A. Harrison, Marc Daigneault

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Neutrophil Elastase Promotes Interleukin-1β Secretion from Human Coronary Endothelium

Mabruka Alfaidi, Heather L. Wilson, Marc Daigneault, Amanda Burnett et autres

The endothelium is critically involved in the pathogenesis of atherosclerosis by producing pro-inflammatory mediators, including IL-1β. Coronary arteries from patients with ischemic heart disease express large amounts of IL-1β in the endothelium. However, the mechanism by which endothelial cells (ECs) release IL-1β …

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200 NEUTROPHIL-DERIVED MICROPARTICLES MODULATE MONOCYTE MIGRATION IN AN ENDOTHELIAL DEPENDENT MANNER

Amanda Burnett, Marc Daigneault, Paul G. Hellewell, Victoria Ridger

Introduction Neutrophil depletion can delay atherogenesis and conversely increasing circulating neutrophils enhances plaque progression in mice. Lack of evidence for the presence of neutrophils in atherosclerotic plaques makes their role in disease progression less clear. Neutrophils may have a greater role in …

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235 TRIBBLES-1 CONTRIBUTES TO MONOCYTE MIGRATION IN EXPERIMENTAL PERITONITIS

Adri Angyal, Marc Daigneault, Éva Hadadi, Mark P. Ariaans et autres

Introduction Mitogen activated protein kinase (MAPK) cascades are involved in the regulation of several cellular responses including migration or proliferation. We have shown previously that tribbles-1 (trb-1), a member of the tribbles family of adaptor/scaffold proteins controls vascular smooth muscle proliferation and …

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208 A NOVEL ROLE FOR THE GAS3/PMP22 FAMILY MEMBER EMP2 IN THE REGULATION OF INFLAMMATION

Marc Daigneault, Adri Angyal, Éva Hadadi, J Baskerville et autres

Introduction Cardiovascular disease such as atherosclerosis is currently the leading cause of death by noncommunicable diseases worldwide. Development of atherosclerosis which is considered a chronic inflammatory disease has been associated with a number of pro-inflammatory cytokines including interleukin-1 (IL-1). IL-1 has been …

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Monocytes Regulate the Mechanism of T-cell Death by Inducing Fas-Mediated Apoptosis during Bacterial Infection

Marc Daigneault, Thushan I. de Silva, Martin A. Bewley, Julie A. Preston et autres

Monocytes and T-cells are critical to the host response to acute bacterial infection but monocytes are primarily viewed as amplifying the inflammatory signal. The mechanisms of cell death regulating T-cell numbers at sites of infection are incompletely characterized. T-cell death in cultures …

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A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia

Helen M. Marriott, Marc Daigneault, A. A. Roger Thompson, Sarah R. Walmsley et autres

BACKGROUND: Therapeutic strategies to modulate the host response to bacterial pneumonia are needed to improve outcomes during community-acquired pneumonia. This study used mice with impaired Fas signalling to examine susceptibility to pneumococcal pneumonia and decoy receptor 3 analogue (DcR3-a) to correct factors …

gb, us (code pays fourni par la source)

Cross-talk between monocytes and T–lymphocytes modifies cell death processes following Streptococcus pneumoniae infection

Marc Daigneault, Julie A. Preston, Paul Collini, David H. Dockrell

Monocyte death processes are subverted by meningococci

Steve J. Webster, Marc Daigneault, Helen M. Marriott, Martin A. Bewley et autres

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